A multifaceted intervention strategy for eradication of a hospital-wide outbreak caused by carbapenem-resistant Klebsiella pneumoniae in southern Israel

Infection Control and Hospital Epidemiology

Volumn 32, Issue 12, 2011, Pages 1158-1165

  Borer, Abraham ^a   Eskira, Seada ^a   Nativ, Ronit ^a   Saidel Odes, Lisa ^a   Riesenberg, Klaris ^a   Livshiz Riven, Ilana ^a   Schlaeffer, Francisc ^a   Sherf, Michael ^a   Peled, Nejama ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; MEROPENEM;

ADULT; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DEMOGRAPHY; DISEASE SURVEILLANCE; EPIDEMIC; FEMALE; HOSPITAL INFECTION; HUMAN; INTERVENTION STUDY; ISRAEL; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; QUASI EXPERIMENTAL STUDY; RETROSPECTIVE STUDY; TERTIARY HEALTH CARE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CARBAPENEMS; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; FECES; FEMALE; HUMANS; INFECTION CONTROL; ISRAEL; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; NURSING HOMES; PATIENT ISOLATION; THIENAMYCINS; YOUNG ADULT;

EID: 80955145090     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/662620     Document Type: Article

References (16)

1. Nordmann P, Cuzon G, Nass T. The real treat of Klebsiella pneumoniae carbapenase-producing bacteria. Lancet Infect Dis 2009;9:228-236.
2. Souli M, Galani I, Antoniadou A, et al. An outbreak of infection due to b-lactamase Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae in a Greek university hospital: mo- lecular characterization, epidemiology, and outcomes. Clin Infect Dis 2010;50:364-373.
3. Borer A, Saidel-Odes L, Riesenberg K, et al. Attributable mor- tality rate of carbapenem-resistant Klebsiella pneumoniae bacteremia. Infect Control Hosp Epidemiol 2009;30:972-976.
4. Centers for Disease Control and Prevention. Guidelines for control of infections with carbapenem-resistant or carbapenemase- producing Enterobacteriaceae in acute care settings. MMWR Morb Mortal Wkly Rep 2009;58:256-260.
5. World Health Organization Collaborating Center for Drug Sta- tistics Methodology. ATC/DDD index 2011. Last updated August 11, 2008. http://www.whocc.no/atcddd.
6. Clinical Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing: 16th informational supplement. CLSI document M100-S16. Wayne, PA: CLSI, 2006.
7. Anderson KF, Lonsway DR, Rasheed JK, et al. Evaluation of methods to identify the Klebsiella pneumoniae carbapenase in Enterobacteriaceae. J Clin Microbiol 2007;45:2723-2725.
8. Wagner AK, Soumerai SB, Zhang F, Ross-Degnan D. Segmented regression analysis of interrupted time series studies in medi- cation use research. J Clin Pharm Ther 2002;27:299-309.
9. Navon-Venezia S, Leavitt A, Schwaber M, et al; Israeli HPC Kpn Study Group. First report on a hyperepidemic clone of KPC-3- producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States. Antimicrob Agents Chemother 2009;53:818-820.
10. Harris AD, McGregor JC, Furuno JP. What infection control interventions should be undertaken to control multidrug-resistant gram-negative bacteria? Clin Infect Dis 2006;43:S57-S61.
11. Saidel-Odes L, Polachek H, Peled N, et al. Randomized, double-blind, placebo-controlled phase 4 trial of selective digestive de- contamination (SDD) with oral gentamicin and polymyxin E for eradication of carbapenem-resistant Klebsiella pneumonia (CRKP) carriage. Abstract presented at: 50th Interscience Con-ference on Antimicrobial Agents and Chemotherapy; September 12-15, 2010; Boston.
12. Talon D, Vichard P, Muller A, Bertin M, Jeunet L, Bertrand X. Modelling the usefulness of a dedicated cohort facility to prevent the dissemination of MRSA. J Hosp Infect 2003;54:57-62.
13. Ben-Daviv D, Maor Y, Keller N, et al. Potential role of active surveillance in the control of a hospital-wide outbreak of car- bapenem-resistant Klebsiella pneumoniae infection. Infect Con- trol Hosp Epidemiol 2010;31:620-626.
14. Lemmen SW, Hafner H, Zolldann D, Stanzel S, Lutticken R. Distribution of multi-resistant gram-negative versus gram-positive bacteria in the hospital inanimate environment. J Hosp Infect 2004;56:191-197.
15. Hussein K, Sprecher J, Mashiach T, Oren I, Kassis I, Finkelstein R. Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility pat- terns. Infect Control Hosp Epidemiol 2009;30:666-671.
16. Schwaber MJ, Klarfeld L, Navon-Venezia S, Schwartz D, Leavitt A, Carmeli Y. Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality. Antimicrob Agents Chemother 2008;52: 1028-1033.