Parakeratosis in skin is associated with loss of inhibitor of differentiation 4 via promoter methylation

Human Pathology

Volumn 42, Issue 12, 2011, Pages 1878-1887

  Ruchusatsawat, Kriangsak ^a   Wongpiyabovorn, Jongkonnee ^b   Protjaroen, Phantipa ^b   Chaipipat, Mookda ^b   Shuangshoti, Shanop ^b   Thorner, Paul Scott ^b,c   Mutirangura, Apiwat ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

DNA methylation; ID4; Immunohistochemistry; Parakeratosis; Psoriasis

Indexed keywords

INHIBITOR OF DIFFERENTIATION 4 PROTEIN; INHIBITOR OF DIFFERENTIATION PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL LINE; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; ECZEMA; EPIDERMIS; GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; NUCLEOTIDE SEQUENCE; PARAKERATOSIS; PROMOTER REGION; PROTEIN EXPRESSION; PSORIASIS; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; DNA METHYLATION; DOWN-REGULATION; ECZEMA; EPIDERMIS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBITOR OF DIFFERENTIATION PROTEINS; KERATINOCYTES; PARAKERATOSIS; PROMOTER REGIONS, GENETIC; PSORIASIS; RNA, MESSENGER; SKIN; SKIN NEOPLASMS;

EID: 80955133904     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2011.02.005     Document Type: Article

References (28)

1. S.P. Brady Parakeratosis J Am Acad Dermatol 50 2004 77 84 (Pubitemid 38095656)
2. J.L. Oestreicher, I.B. Walters, and T. Kikuchi Molecular classification of psoriasis disease-associated genes through pharmacogenomic expression profiling Pharmacogenomics J 1 2001 272 287 (Pubitemid 33756652)
3. A.M. Bowcock, W. Shannon, and F. Du Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies Hum Mol Genet 10 2001 1793 1805 (Pubitemid 32899097)
4. M. Rigolet, T. Rich, and M.S. Gross-Morand cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene DNA Res 5 1998 309 313 (Pubitemid 128670169)
5. M.E. Massari, and C. Murre Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms Mol Cell Biol 20 2000 429 440 (Pubitemid 30023084)
6. P.Y. Desprez, T. Sumida, and J.P. Coppe Helix-loop-helix proteins in mammary gland development and breast cancer J Mammary Gland Biol Neoplasia 8 2003 225 239 (Pubitemid 38129944)
7. T. Kondo, and M. Raff The Id4 HLH protein and the timing of oligodendrocyte differentiation Embo J 19 2000 1998 2007 (Pubitemid 30237575)
8. P.J. Andres-Barquin, M.C. Hernandez, and M.A. Israel Id4 expression induces apoptosis in astrocytic cultures and is down-regulated by activation of the cAMP-dependent signal transduction pathway Exp Cell Res 247 1999 347 355 (Pubitemid 29394772)
9. J. Samanta, and J.A. Kessler Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation Development 131 2004 4131 4142 (Pubitemid 39276185)
10. L. Yu, C. Liu, and J. Vandeusen Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia Nat Genet 37 2005 265 274 (Pubitemid 41716253)
11. A.S. Chan, W.Y. Tsui, and X. Chen Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma Oncogene 22 2003 6946 6953 (Pubitemid 37386696)
12. N. Umetani, T. Mori, and K. Koyanagi Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer Oncogene 24 2005 4721 4727 (Pubitemid 41032608)
13. N. Umetani, H. Takeuchi, and A. Fujimoto Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis Clin Cancer Res 10 2004 7475 7483 (Pubitemid 39557508)
14. H.F. Yuen, C.W. Chua, and Y.P. Chan Id proteins expression in prostate cancer: high-level expression of Id-4 in primary prostate cancer is associated with development of metastases Mod Pathol 19 2006 931 941
15. Q. Wu, M.J. Hoffmann, F.H. Hartmann, and W.A. Schulz Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer Mol Cancer 4 2005 16
16. K.O. Uhm, E.S. Lee, and Y.M. Lee Aberrant promoter CpG islands methylation of tumor suppressor genes in cholangiocarcinoma Oncol Res 17 2008 151 157
17. K. Hagiwara, H. Nagai, and Y. Li Frequent DNA methylation but not mutation of the ID4 gene in malignant lymphoma J Clin Exp Hematop 47 2007 15 18
18. T. Kubota, S. Das, and S.L. Christian Methylation-specific PCR simplifies imprinting analysis Nat Genet 16 1997 16 17
19. E. Noetzel, J. Veeck, and D. Niederacher Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer BMC Cancer 8 2008 154
20. J. Wongpiyabovorn, H. Suto, and H. Ushio Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis J Dermatol Sci 33 2003 31 40 (Pubitemid 37188475)
21. P.A. Jones, and S.B. Baylin The fundamental role of epigenetic events in cancer Nat Rev Genet 3 2002 415 428 (Pubitemid 34587077)
22. T.J. Jang, K.H. Jung, and E.A. Choi Id-1 gene downregulation by sulindac sulfide and its upregulation during tumor development in gastric cancer Int J Cancer 118 2006 1356 1363
23. C. Manthey, D.S. Mern, and A. Gutmann Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells BMC Cell Biol 11 2010 2
24. T. Gomez Del Pulgar, F. Valdes-Mora, and E. Bandres Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism Int J Oncol 33 2008 185 193
25. Y. Du, B.C. Bock, K.A. Schachter, M. Chao, and K.A. Gallo Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3 J Biol Chem 280 2005 42984 42993 (Pubitemid 43049262)
26. S. Wery-Zennaro, J.L. Zugaza, M. Letourneur, J. Bertoglio, and J. Pierre IL-4 regulation of IL-6 production involves Rac/Cdc42- and p38 MAPK-dependent pathways in keratinocytes Oncogene 19 2000 1596 1604 (Pubitemid 30175682)
27. C. Johansen, K. Kragballe, and M. Westergaard The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin Br J Dermatol 152 2005 37 42
28. I. Haase, R.M. Hobbs, M.R. Romero, S. Broad, and F.M. Watt A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis J Clin Invest 108 2001 527 536 (Pubitemid 32777732)