CD49d blockade by natalizumab therapy in patients with multiple sclerosis increases immature B-lymphocytes

Bone Marrow Transplantation

Volumn 46, Issue 11, 2011, Pages 1489-1491

  Lesesve, J F ^a   Debouverie, M ^a   Decarvalho Bittencourt, M ^a   Bene M C ^a  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; CD19 ANTIGEN; CELL ADHESION MOLECULE; NATALIZUMAB;

B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DRUG EFFECT; HUMAN; IMMUNOPHENOTYPING; LETTER; LYMPHOCYTE COUNT; LYMPHOCYTOSIS; MULTIPLE SCLEROSIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT DURATION;

ANTIBODIES, MONOCLONAL; ERYTHROID PRECURSOR CELLS; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTEGRIN ALPHA4; MALE; MULTIPLE SCLEROSIS;

EID: 80855156819     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2010.328     Document Type: Letter

References (8)

1. Jing D, Oelschlaegel U, Ordemann R, Hoälig K, Ehninger G, Reichmann H et al. CD49d blockade by natalizumab in patients with multiple sclerosis affects steady-state hematopoiesis and mobilizes progenitors with a distinct phenotype and function. Bone Marrow Transplant 2010; 45: 1489-1496.
2. Stuäve O. The effects of natalizumab on the innate and adaptive immune system in the nervous system. J Neurological Sci 2008; 274: 39-41.
3. Stuäve O, Marra CM, Jerome KR, Cook L, Cravens PD, Cepok S et al. Immune surveillance in multiple sclerosis patients treated with natalizumab. Annal Neurol 2006; 59: 743-747. (Pubitemid 43673151)
4. Krumbholz M, Meinl I, Kumpfel T, Hohleld R, Meinl E. Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 2008; 71: 1350-1354.
5. Lesesve JF, Debouverie M, Decarvalho M, Pittion-Vouyovitch S, Grégoire MJ, Béné MC. Peripheral blood lymphocytosis characterization after Natalizumab therapy in patients with multiple sclerosis (submitted).
6. Leclerc M, Lesesve JF, Gaillard B, Troussard X, Tourbah A, Debouverie M et al. Binucleated lymphocytes in multiple sclerosis patients treated with natalizumab. Leuk Lymphoma (accepted).
7. Le Naour F, André M, Boucheix C, Rubinstein E. Membrane microdomains and proteomics: Lessons from tetraspanin microdomains and comparison with lipid rafts. Proteomics 2006; 6: 6447-6454. (Pubitemid 46048385)
8. Stuäve O, Eagar TN. B cells, antibodies, and tertiary lymphoid tissue in MS brains. Lancet Neurol 2008; 7: 766-767.