The BRAF V600E mutation is associated with malignant ultrasonographic features in thyroid nodules

Clinical Endocrinology

Volumn 75, Issue 6, 2011, Pages 844-850

  Lee, Eun Jung ^a   Song, Kee Ho ^a   Kim, Dong Lim ^a   Jang, Yun Mi ^a   Hwang, Tae Sook ^a   Kim, Suk Kyeong ^a  

^a Konkuk University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE;

ADULT; AGED; ARTICLE; ASPIRATION BIOPSY; CALCIFICATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTODIAGNOSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ECHOGRAPHY; FEMALE; GENE MUTATION; HUMAN; KOREA; MAJOR CLINICAL STUDY; MALE; PARATHYROID CARCINOMA; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PYROSEQUENCING; SENSITIVITY AND SPECIFICITY; THYROID FOLLICULAR CARCINOMA; THYROID NODULE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SUBSTITUTION; BIOPSY, FINE-NEEDLE; DIAGNOSIS, DIFFERENTIAL; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUTAMIC ACID; HUMANS; MALE; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS B-RAF; SENSITIVITY AND SPECIFICITY; THYROID NEOPLASMS; THYROID NODULE; VALINE; YOUNG ADULT;

EID: 80855144837     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2011.04154.x     Document Type: Article

References (38)

1. Choi, Y.J., Park, Y.L., &, Koh, J.H., (2008) Prevalence of thyroid cancer at a medical screening center: pathological features of screen-detected thyroid carcinomas. Yonsei Medical Journal, 49, 748-756.
2. Naik, K.S., &, Bury, R.F., (1998) Imaging the thyroid. Clinical Radiology, 53, 630-639.
3. Brander, A., Viikinkoski, P., Nickels, J., et al. (1991) Thyroid gland: US screening in a random adult population. Radiology, 181, 683-687.
4. Kang, H.W., No, J.H., Chung, J.H., et al. (2004) Prevalence, clinical and ultrasonographic characteristics of thyroid incidentalomas. Thyroid, 14, 29-33. (Pubitemid 38282934)
5. Nam-Goong, I.S., Kim, H.Y., Gong, G., et al. (2004) Ultrasonography- guided fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings. Clinical Endocrinology (Oxford), 60, 21-28. (Pubitemid 38183493)
6. Ravetto, C., Colombo, L., &, Dottorini, M.E., (2000) Usefulness of fine-needle aspiration in the diagnosis of thyroid carcinoma: a retrospective study in 37,895 patients. Cancer, 90, 357-363. (Pubitemid 32011847)
7. Lumachi, F., Borsato, S., Tregnaghi, A., et al. (2004) Accuracy of fine-needle aspiration cytology and frozen-section examination in patients with thyroid cancer. Biomedicine and Pharmacotherapy, 58, 56-60. (Pubitemid 38117049)
8. Brooks, A.D., Shaha, A.R., DuMornay, W., et al. (2001) Role of fine-needle aspiration biopsy and frozen section analysis in the surgical management of thyroid tumors. Annals of Surgical Oncology, 8, 92-100. (Pubitemid 32199404)
9. Hamberger, B., Gharib, H., Melton 3rd, L.J., et al. (1982) Fine-needle aspiration biopsy of thyroid nodules. Impact on thyroid practice and cost of care. American Journal of Medicine, 73, 381-384. (Pubitemid 12031790)
10. Miller, B., Burkey, S., Lindberg, G., et al. (2004) Prevalence of malignancy within cytologically indeterminate thyroid nodules. American Journal of Surgery, 188, 459-462. (Pubitemid 39491085)
11. Peyssonnaux, C., &, Eychene, A., (2001) The Raf/MEK/ERK pathway: new concepts of activation. Biology of the Cell, 93, 53-62. (Pubitemid 33040860)
12. Hilger, R.A., Scheulen, M.E., &, Strumberg, D., (2002) The Ras-Raf-MEK-ERK pathway in the treatment of cancer. Onkologie, 25, 511-518. (Pubitemid 36173389)
13. National Cancer Centre K. (2003) 2002 annual report of the Korea Central Cancer Rgistry. URL (last accessed: February 2005).
14. Chung, K.W., Yang, S.K., Lee, G.K., et al. (2006) Detection of BRAFV600E mutation on fine needle aspiration specimens of thyroid nodule refines cyto-pathology diagnosis, especially in BRAF600E mutation-prevalent area. Clinical Endocrinology (Oxford), 65, 660-666. (Pubitemid 44583829)
15. Cerbone, G., Spiezia, S., Colao, A., et al. (1999) Power Doppler improves the diagnostic accuracy of color Doppler ultrasonography in cold thyroid nodules: follow-up results. Hormone Research, 52, 19-24. (Pubitemid 30071924)
16. Kim, E.K., Park, C.S., Chung, W.Y., et al. (2002) New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. AJR. American Journal of Roentgenology, 178, 687-691.
17. Kim, J.Y., Lee, C.H., Kim, S.Y., et al. (2008) Radiologic and pathologic findings of nonpalpable thyroid carcinomas detected by ultrasonography in a medical screening center. Journal of Ultrasound in Medicine, 27, 215-223.
18. Moon, W.J., Jung, S.L., Lee, J.H., et al. (2008) Benign and malignant thyroid nodules: US differentiation - multicenter retrospective study. Radiology, 247, 762-770.
19. Takashima, S., Fukuda, H., Nomura, N., et al. (1995) Thyroid nodules: re-evaluation with ultrasound. Journal of Clinical Ultrasound, 23, 179-184.
20. Marqusee, E., Benson, C.B., Frates, M.C., et al. (2000) Usefulness of ultrasonography in the management of nodular thyroid disease. Annals of Internal Medicine, 133, 696-700.
21. Alexander, E.K., Heering, J.P., Benson, C.B., et al. (2002) Assessment of nondiagnostic ultrasound-guided fine needle aspirations of thyroid nodules. Journal of Clinical Endocrinology and Metabolism, 87, 4924-4927. (Pubitemid 35316326)
22. Koike, E., Noguchi, S., Yamashita, H., et al. (2001) Ultrasonographic characteristics of thyroid nodules: prediction of malignancy. Archives of Surgery, 136, 334-337. (Pubitemid 32204972)
23. Papini, E., Guglielmi, R., Bianchini, A., et al. (2002) Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. Journal of Clinical Endocrinology and Metabolism, 87, 1941-1946. (Pubitemid 34521470)
24. Xing, M., Tufano, R.P., Tufaro, A.P., et al. (2004) Detection of BRAF mutation on fine needle aspiration biopsy specimens: a new diagnostic tool for papillary thyroid cancer. Journal of Clinical Endocrinology and Metabolism, 89, 2867-2872. (Pubitemid 38766378)
25. Jin, L., Sebo, T.J., Nakamura, N., et al. (2006) BRAF mutation analysis in fine needle aspiration (FNA) cytology of the thyroid. Diagnostic Molecular Pathology, 15, 136-143. (Pubitemid 44325474)
26. Kumagai, A., Namba, H., Akanov, Z., et al. (2007) Clinical implications of pre-operative rapid BRAF analysis for papillary thyroid cancer. Endocrine Journal, 54, 399-405. (Pubitemid 47105427)
27. Sapio, M.R., Posca, D., Raggioli, A., et al. (2007) Detection of RET/PTC, TRK and BRAF mutations in preoperative diagnosis of thyroid nodules with indeterminate cytological findings. Clinical Endocrinology (Oxford), 66, 678-683. (Pubitemid 46699541)
28. Kwak, J.Y., Kim, E.K., Chung, W.Y., et al. (2009) Association of BRAFV600E mutation with poor clinical prognostic factors and US features in Korean patients with papillary thyroid microcarcinoma. Radiology, 253, 854-860.
29. Hwang, J., Shin, J.H., Han, B.K., et al. (2010) Papillary thyroid carcinoma with BRAFV600E mutation: sonographic prediction. AJR. American Journal of Roentgenology, 194, W425-W430.
30. Nam, S.Y., Han, B.K., Ko, E.Y., et al. (2010) BRAF(V600E) Mutation Analysis of Thyroid Nodules Needle Aspirates in Relation to Their Ultrasongraphic Classification: a Potential Guide for Selection of Samples for Molecular Analysis. Thyroid, 20, 273-279.
31. Kim, K.H., Kang, D.W., Kim, S.H., et al. (2004) Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population. Yonsei Medical Journal, 45, 818-821.
32. Xing, M., Westra, W.H., Tufano, R.P., et al. (2005) BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. Journal of Clinical Endocrinology and Metabolism, 90, 6373-6379. (Pubitemid 41759286)
33. Kim, T.Y., Kim, W.B., Rhee, Y.S., et al. (2006) The BRAF mutation is useful for prediction of clinical recurrence in low-risk patients with conventional papillary thyroid carcinoma. Clinical Endocrinology (Oxford), 65, 364-368.
34. Nikiforov, Y.E., Steward, D.L., Robinson-Smith, T.M., et al. (2009) Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules. Journal of Clinical Endocrinology and Metabolism, 94, 2092-2098.
35. Kim, T.Y., Kim, W.B., Song, J.Y., et al. (2005) The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma. Clinical Endocrinology (Oxford), 63, 588-593. (Pubitemid 41626756)
36. Kim, S.K., Kim, D.L., Han, H.S., et al. (2008) Pyrosequencing analysis for detection of a BRAFV600E mutation in an FNAB specimen of thyroid nodules. Diagnostic Molecular Pathology, 17, 118-125.
37. Xing, M., (2005) BRAF mutation in thyroid cancer. Endocrine-Related Cancer, 12, 245-262. (Pubitemid 40896444)
38. Xing, M., (2007) BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocrine Reviews, 28, 742-762. (Pubitemid 350294294)