Long-term survival benefits of adjuvant chemotherapy by decreasing incidence of tumor recurrence without delaying relapse in stage III colorectal cancer

International Journal of Colorectal Disease

Volumn 26, Issue 10, 2011, Pages 1329-1338

  Tsai, Wen Sy ^a   Hsieh, Pao Shiu ^a   Yeh, Chien Yuh ^a   Chiang, Jy Ming ^a   Tang, Reiping ^a   Chen, Jinn Shiun ^a   Changchien, Chung Rong ^a   Wang, Jeng Yi ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

5 FU; Adjuvant; Colorectal cancer; Long term survival

Indexed keywords

FLUOROURACIL; LEVAMISOLE;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER RECURRENCE; CANCER RELAPSE; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; SURVIVAL RATE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHEMOTHERAPY, ADJUVANT; COLORECTAL NEOPLASMS; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; POSTOPERATIVE PERIOD; PROPORTIONAL HAZARDS MODELS; RECTAL NEOPLASMS; RECURRENCE; TAIWAN; TIME FACTORS; YOUNG ADULT;

EID: 80855144169     PISSN: 01791958     EISSN: 14321262     Source Type: Journal    
DOI: 10.1007/s00384-011-1214-8     Document Type: Article

References (45)

1. Dwight RW, Humphrey EW, Higgins GA et al (1973) FUDRas an adjuvant to surgery in cancer of large bowel. J Surg Oncol 5:243-249
2. Higgins GA, Dwight RW, Smith JV et al (1971) Fluorouracil as an adjuvant to surgery in carcinoma of common. Arch Surg 102:339-343
3. Higgins GA, Humphrey EW, Juler GL et al (1976) Adjuvant chemotherapy and the surgical treatment of large bowel cancer. Cancer 38:1461-1467
4. Higgins GA Jr, Donaldson RC, Humphrey EW et al (1981) Adjuvant therapy for large bowel cancer: Update of Veterans Administration Surgical Oncology Group Trials. Surg Clin North Am 61:1311-1320 (Pubitemid 12152893)
5. Grage TB, Moss SE (1981) Adjuvant chemotherapy in cancer of the colon and rectum: Demonstration of effectiveness of prolonged 5-FU chemotherapy in a prospectively controlled randomized trial. Surg Clin North Am 61:1321-1329 (Pubitemid 12152894)
6. Laurie JA, Mortel CG, Fleming TR et al (1989) Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil. The North Central Cancer Treatment Group and the Mayo Clinic. J Clin Oncol 7:1447-1456 (Pubitemid 19245114)
7. Mortel CG, Fleming TR, MacDonald JS et al (1990) Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 322:352-358 (Pubitemid 20042739)
8. Macdonald JS (1999) Adjuvant therapy for colon cancer. CA Cancer J Clin 49:202-219
9. Edge SB, Byrd DR, Compton AC et al (2010) AJCC Cancer Staging Manual, 7th edn. Spring, New York
10. Glaves D (1983) Correlation between circulating cancer cells and incidence of metastases. Br J Cancer 48:665-673 (Pubitemid 14248307)
11. Allen-March TG, McCullough TK, Patel H, Wharton RQ, Glover C, Jonas SK (2007) Roles of circulating tumor cells in predicting recurrence after excision of primary colorectal carcinoma. Br J Surg 94:96-105 (Pubitemid 46142739)
12. Obrand DI, Gordon PH (1997) Incidence and patterns of recurrence following curative resection for colorectal carcinoma. Dis Colon Rectum 40:15-24 (Pubitemid 27056393)
13. Sargent D, Sobrero A, Grothey A, O'Connell MJ, Buyse M, Andre T, Zheng Y, Green E, Labianca R, O'Callaghan C, Seitz JF, Francini G, Haller D, Yothers G, Goldberg R, de Gramont A (2009) Evidence for cure by adjuvant therapy in colon cancer: Observations based on individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol 27:872-877
14. Buroker TR, Moertel CG, Fleming TR et al (1985) A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fuorouracil therapy in colorectal carcinoma. J Clin Oncol 3:1624-1631 (Pubitemid 16199214)
15. Windle R, Bell PR, Shaw D (1987) Five year results of a randomized trial of adjuvant 5-fluorouracil and levamisole in colorectal cancer. Br J Surg 74:569-572 (Pubitemid 17102492)
16. Poon MA, O'Connell MJ, Moertel CG et al (1989) Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 7:1407-1418 (Pubitemid 19245110)
17. Wolmark N, Rockette H, Fisher B et al (1993) The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: Results from National Surgical Adjuvant Breast and Bowel Project protocol C-03. J Clin Oncol 11:1879-1887 (Pubitemid 23304611)
18. Wolmark N, Rockette H, Mamounas E et al (1999) Clinical trial to assess the relative eficacy of fuorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: Results from National Surgical Adjuvant Breast and Bowel Project C-04. J Clin Oncol 17:3553-3559 (Pubitemid 29517927)
19. Gill S, Loprinzi CL, Sargent DJ et al (2004) Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: Who benefits and by how much? J Clin Oncol 22:1797-1806 (Pubitemid 41095169)
20. Thirion P, Michiels S, Pignon JP et al (2004) Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: An updated meta-analysis. J Clin Oncol 22:3766-3775
21. Haller DG, Catalano PJ, Macdonald JS et al (2005) Phase III study of fluorouracil, leucovorin, and levamisole in high-risk stage II and III colon cancer: Final report of Intergroup 0089. J Clin Oncol 23:8671-8678 (Pubitemid 46211510)
22. Andre T, Colin P, Louvet C et al (2003) Semimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage II and III colon cancer: Results of a randomized trial. J Clin Oncol 21:2896-2903 (Pubitemid 46621839)
23. Chau I, Norman AR, Cunningham D et al (2005) A randomised comparison between 6 months of bolus fuorouracil/leucovorin and 12 weeks of protracted venous infusion fluorouracil as adjuvant treatment in colorectal cancer. Ann Oncol 16:549-557 (Pubitemid 40613320)
24. Poplin EA, Benedetti JK, Estes NC et al (2005) Phase III Southwest Oncology Group 9415/Intergroup 0153 randomized trial of fluorouracil, leucovorin, and levamisole versus fluorouracil continuous infusion and levamisole for adjuvant treatment of stage III and high-risk stage II colon cancer. J Clin Oncol 23:1819-1825 (Pubitemid 46211360)
25. Arkenau HT, Retting K, Porschen R (2005) Adjuvant chemotherapy in curative resected colon carcinoma: 5-fluorouracil/leucovorin versus high-dose 5-fluorouracil 24-h infusion/leucovorin versus high-dose 5-fluorouracil 24-h infusion. Int J Colorectal Dis 20:258-261 (Pubitemid 40553005)
26. de Gramont A, Figer A, Seymour M et al (2000) Leucovorin and fluorouracil with and without oxalipatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18:2938-2947 (Pubitemid 30644117)
27. Saltz LB, Cox JV, Blanke C et al (2000) Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer: Irinotecan Study Group. N Engl J Med 343:905-914
28. Saltz LB, Niedzwiecki D, Hollis D et al (2007) Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: Results of CALGB 89803. J Clin Oncol 25:3456-3461 (Pubitemid 47310883)
29. van Cutsem E, Labianca R, Hossfeld D et al (2009) Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer PETACC-3. J Clin Oncol 27:3117-3125
30. Ychou M, Raoul JL, Douillard JY (2009) A phase III randomised trial of LV5FU2+irinotecan versus LV5FU2 alone in adjuvant high-risk colon cancer (FNCLCC Accord02/FFCD9802). Ann Oncol 20:674-680
31. André T, Boni C, Mounedji-Boudiaf L et al (2004) Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350:2343-2351 (Pubitemid 38702845)
32. Kuebler JP, Wieand HS, O'Connell MJ et al (2007) Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07. J Clin Oncol 25:2198-2204 (Pubitemid 46954643)
33. Colucci G, Gebbia V, Paoletti G et al (2005) Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: A multicenter study of the Gruppo Oncologico Dell'Italia Meridionale. J Clin Oncol 23:4866-4875 (Pubitemid 46223991)
34. Dy GK, Krook JE, Green EM et al (2007) Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: Results from intergroup N9741. J Clin Oncol 25:3469-3474 (Pubitemid 47310885)
35. Köhne CH, van Cutsem E, Wils J et al (2005) Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986. J Clin Oncol 23:4856-4865 (Pubitemid 46223990)
36. Twelves C, Wong A, Nowacki MP et al (2005) Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med 352:2696-2704 (Pubitemid 41007824)
37. Land SR, Kopec JA, Cecchini RS, Ganz PA et al (2007) Neurotoxicity from oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: NSABP C-07. J Clin Oncol 25:2205-2211 (Pubitemid 46954644)
38. Neugut AI, Matasar M, Wang X et al (2006) Duration of adjuvant chemotherapy for colon cancer and survival among the eldery. J Clin Oncol 24:2368-2375 (Pubitemid 46630669)
39. Popat S, Hubner R, Houlston RS (2005) Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol 23:609-618 (Pubitemid 46224239)
40. Jover R, Zapater P, Castells A et al (2006) Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer. Gut 55:848-855 (Pubitemid 43764557)
41. Thirion P, Piedbois P, Buyse M et al (2001) Alpha-interferon does not increase the efficacy of 5-fluorouracil in advanced colorectal cancer. Br J Cancer 84:611-620 (Pubitemid 32238993)
42. Meta-Analysis Group in Cancer (1998) Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 16:301-308
43. Pantel K, Brakenhoff RH, Branbdt B (2008) Detection, clinical relevance and specific biological properties of disseminating tumor cells. Nat Rev Cancer 8:329-340 (Pubitemid 351596394)
44. Rahbari NN, Aigner M, Thorlund K et al (2010) Meta-analysis shows that detection of circulating tumor cells indicates poor prognosis in patients with colorectal cancer. Gastroenterology 138:1714-1726
45. Yih-Huei U, Chien-Yu L, Hsiang-Lin T et al (2008) Persistent presence of postoperative circulating tumor cells is a poor prognostic factor for patients with stage I-III colorectal cancer after curative resection. Ann Surg Oncol 15:2120-2128