Hematopoietic stem cell transplantation with reduced intensity conditioning from a family haploidentical donor in an infant with familial hemophagocytic lymphohistocytosis

International Journal of Hematology

Volumn 94, Issue 3, 2011, Pages 285-290

  Ohta, Hideaki ^a   Miyashita, Emiko ^a   Hirata, Ikuko ^a   Matsumura, Risa ^a   Yoshida, Hisao ^a   Hashii, Yoshiko ^a   Higashiura, Takeshi ^b   Yasumi, Takahiro ^c   Murata, Yuuki ^c   Heike, Toshio ^c   Yang, Xi ^d   Kanegane, Hirokazu ^d   Ohara, Osamu ^e   Ozono, Keiichi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Suita Municipal Hospital   (Japan)

^c KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF TOYAMA   (Japan)

^e KAZUSA DNA RESEARCH INSTITUTE   (Japan)

Author keywords

Allogeneic hematopoietic stem cell transplantation; Familial hemophagocytic lymphohistocytosis; Haploidentical; Munc13 4; Reduced intensity conditioning

Indexed keywords

BUSULFAN; DEXAMETHASONE; DIHYDROCYCLOSPORIN A; ETOPOSIDE; FIBRIN; FIBRINOGEN; FLUDARABINE; MELPHALAN; MEROPENEM; METHOTREXATE; PERFORIN; PREDNISOLONE; TACROLIMUS;

ACUTE GRAFT VERSUS HOST DISEASE; ADULT; ANEMIA; ARTICLE; BONE MARROW BIOPSY; CASE REPORT; ERYTHROPHAGOCYTOSIS; FAR WESTERN BLOTTING; FEMALE; FEVER; FIBRINOGEN BLOOD LEVEL; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HEPATOSPLENOMEGALY; HUMAN; PANCYTOPENIA; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; SEPSIS; THROMBOCYTOPENIA; URINARY TRACT INFECTION;

FEMALE; GRAFT VS HOST DISEASE; HAPLOIDY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HETEROZYGOTE; HUMANS; INFANT; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MEMBRANE PROTEINS; MUTATION; PREDNISOLONE; TISSUE DONORS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 80855140817     PISSN: 09255710     EISSN: 18653774     Source Type: Journal    
DOI: 10.1007/s12185-011-0916-6     Document Type: Article

References (19)

1. Ishii E, Ohga S, Imashuku S, Kimura N, Ueda I, Morimoto A, et al. Review of hemophagocytic lymphohistiocytosis (HLH) in children with focus on Japanese experiences. Crit Rev Oncol Hematol. 2005;53:209-23. (Pubitemid 40254920)
2. Janka GE. Hemophagocytic syndromes. Blood Rev. 2007;21: 245-53. (Pubitemid 47212601)
3. Filipovich A, McClain K, Grom A. Histiocytic disorders: Recent insights into pathophysiology and practical guidelines. Biol Blood Marrow Transplant. 2010;16:S82-9.
4. Henter JI, Samuelsson-Horne A, Arico M, Egeler RM, Elinder G, Filipovich AH, et al. Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation. Blood. 2002;100:2367-73.
5. Horne A, Janka G, Maarten Egeler R, Gadner H, Imashuku S, Ladisch S, et al. Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis. Br J Haematol. 2005;129:622-30. (Pubitemid 40825824)
6. Ouachée-Chardin M, Elie C, de Saint Basile G, Le Deist F, Mahlaoui N, Picard C, et al. Hematopoietic stem cell transplantation in hemophagocytic lymphohistiocytosis: A single-center report of 48 patients. Pediatrics. 2006;117:e743-50. (Pubitemid 46071479)
7. Cesaro S, Locatelli F, Lanino E, Porta F, Di Maio L, Messina C, et al. Hematopoietic stem cell transplantation for hemophagocytic lymphohistiocytosis: A retrospective analysis of data from the Italian Association of Pediatric Hematology Oncology (AIEOP). Haematologica. 2008;93:1694-701.
8. Ohga S, Kudo K, Ishii E, Honjo S, Morimoto A, Osugi Y, et al. Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan. Pediatr Blood Cancer. 2010;54:299-306.
9. Cooper N, Rao K, Goulden N, Webb D, Amrolia P, Veys P. The use of reduced-intensity stem cell transplantation in haemophagocytic lymphohistiocytosis and Langerhans cell histiocytosis. Bone Marrow Transplant. 2008;42(Suppl 2):S47-50.
10. Cǒte M, Ménager MM, Burgess A, Mahlaoui N, Picard C, Schaffner C, et al. Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic] granule exocytosis in patient NK cells. J Clin Invest. 2009;119: 3765-73.
11. Zur Stadt U, Beutel K, Kolberg S, Schneppenheim R, Kabisch H, Janka G, et al. Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: Molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A. Hum Mutat. 2006;27:62-8. (Pubitemid 43042967)
12. Ishii E, Ueda I, Shirakawa R, Yamamoto K, Horiuchi H, Ohga S, et al. Genetic subtypes of familial hemophagocytic lymphohistiocytosis: Correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions. Blood. 2005;105: 3442-8. (Pubitemid 40628184)
13. Feldmann J, Callebaut I, Raposo G, Certain S, Bacq D, Dumont C, et al. Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Cell. 2003;115:461-73. (Pubitemid 37456808)
14. Nagai K, Yamamoto K, Fujiwara H, An J, Ochi T, Suemori K, et al. Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes. PloS one. 2010;5:e14173.
15. Teinturier C, Hartmann O, Valteau-Couanet D, Benhamou E, Bougneres PF. Ovarian function after autologous bone marrow transplantation in childhood: High-dose busulfan is a major cause of ovarian failure. Bone Marrow Transplant. 1998;22:989-94. (Pubitemid 28543061)
16. Yaniv I, Stein J. Reduced-intensity conditioning in children: A reappraisal in 2008. Bone Marrow Transplant. 2008;41(Suppl 2):S18-22. (Pubitemid 351864701)
17. Ogawa H, Ikegame K, Yoshihara S, Kawakami M, Fujioka T, Masuda T, et al. Unmanipulated HLA 2-3 antigen-mismatched (haploidentical) stem cell transplantation using nonmyeloablative conditioning. Biol Blood Marrow Transplant. 2006;12:1073-84.
18. Yoshihara T, Okada K, Kobayashi M, Kikuta A, Kato K, Adachi N, et al. Outcome of non-T-cell-depleted HLA-haploidentical hematopoietic stem cell transplantation from family donors in children and adolescents. Int J Hematol. 2007;85:246-55. (Pubitemid 46686586)
19. Oh H, Loberiza FR Jr, Zhang MJ, Ringdén O, Akiyama H, Asai T, et al. Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations. Blood. 2005;105:1408-16. (Pubitemid 40223655)