Efficacy of over-the-counter immunostimulants in the prevention of paediatric recurrent acute respiratory tract infections. Criticisms and pitfalls of available metanalyses

European Annals of Allergy and Clinical Immunology

Volumn 43, Issue 5, 2011, Pages 157-161

  Sopo, Stefano Miceli ^a   Onesimo, R ^a   Giorgio, V ^a   Fundaro C ^a   Tabacco, F ^a   Calvani, M ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b SAN CAMILLO DE LELLIS HOSPITAL   (Italy)

Author keywords

Child; Immunostimulant; Metanalysis; Recurrent respiratory infection

Indexed keywords

BACTERIUM LYSATE; IMMUNOSTIMULATING AGENT; NON PRESCRIPTION DRUG; PIDOTIMOD; PLACEBO; RIBOMUNYL;

CHILD; DATA BASE; DRUG EFFICACY; FAMILY; HEALTH CARE; HUMAN; KNOWLEDGE; MEDLINE; META ANALYSIS; PEDIATRICS; QUALITY CONTROL; QUALITY OF LIFE; RECURRENT DISEASE; RESPIRATORY TRACT INFECTION; REVIEW; SCIENTIFIC LITERATURE; SOCIAL PROBLEM; SYSTEMATIC REVIEW;

ACUTE DISEASE; ADJUVANTS, IMMUNOLOGIC; CHILD, PRESCHOOL; EDUCATION, MEDICAL, CONTINUING; HUMANS; META-ANALYSIS AS TOPIC; NONPRESCRIPTION DRUGS; RECURRENCE; RESEARCH DESIGN; RESPIRATORY TRACT INFECTIONS;

EID: 80855139346     PISSN: 03979148     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (17)

1. Boyle P, Bellantu JA, Robertson C. Meta-analysis of published clinical trials of a ribosomal vaccine (Ribomunyl R) in prevention of respiratory infections. Biodrugs 2000; 14: 389-408.
2. Berber A, Del Rio Navarro B. Compilation and meta-analysis of randomized placebo-controlled clinical trials on the prevention of respiratory tract infections in children using immunostimulants. J Investig Allergol Clin Immunol 2001; 11: 235-46.
3. De la Torre Gonzales C, Pacheco Ríos A, Escalante Domínguez AJ, Del Río Navarro BE. Metaanálisis comparativo de los inmunoestimulantes utilizados en pediatría en México. Revi Al Méx 2005; 52: 25-38.
4. Del Rio Navarro BE, Espinosa Rosales F, Flenady V, Sienra-Monge JJL. Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev 2006 Oct 18; (4): CD004974.
5. Steurer Stey C, Lagler L, Straub DA, Steurer J, Bachmann LM. Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Eur J Pediatr 2007; 166: 365-76.
6. Schaad UB. OM-85 BV, an immunostimulant in pediatric recurrent respiratory tract infections: a systematic review. World J Pediatr 2010; 6: 5-12.
7. Collet JP, Ducruet T, Kramer MS, et al. Stimulation of nonspecific immunity to reduce the risk of recurrent infections in children attending day-care centers. The Epicreche Research Group. Pediatric Infect Dis J 1993; 12: 648-52.
8. Del-Río-Navarro BE, Luis Sienra-Monge JJ, Berber A, Torres-Alcántara S, Avila-Castañón L, Gómez-Barreto D. Use of OM-85 BV in children suffering from recurrent respiratory tract infections and subnormal IgG subclass levels. Allergol Immunopathol 2003; 31: 7-13.
9. Jara-Perez JV, Berber A. Primary prevention of acute respiratory tract infections in children using a bacterial immunostimulant: a doublemasked, placebo-controlled clinical trial. Clin Ther 2000; 22: 748-59.
10. Gutiérrez-Tarango MD, Berber A. Safety and efficacy of two courses of om-85 bv in the prevention of respiratory tract infections in children during 12 months. Chest 2001; 119: 1742-8.
11. Schaad UB, Mutterlein R, Goffin H, BV-Child Study Group. Immunostimulation with OM-85 in children with recurrent infections of the upper respiratory tract: a double-blind, placebocontrolled multicenter study. Chest 2002; 122: 2042-9.
12. Maestroni GJ, Losa GA. Clinical and immunobiological effects of an orally administered bacterial extract. Int J Immunopharmacol 1984; 6: 111-7.
13. Schaad UB, Farine JC, Fux TH. Prospective placebo-controlled double-blind study using a bacterial lysate in infections of the respiratory tract and ENT region in children. Helv Paediatr Acta 1986; 41: 7-17.
14. Zagar S, Löfler-Badzek D. Broncho-Vaxom in children with rhinosinusitis: a double-blind clinical trial. ORL J Otorhinolaryngol Relat Spec 1988; 50: 397-404.
15. Paupe J. Immunotherapy with an oral bacterial extract (OM-85) for upper respiratory infections. Respiration 1991; 58: 150-4.
16. Gomez Barreto D, De la Torre C, Alvarez A, Faure A, Berber A. Safety and effi cacy of OM-85-BV plus amoxicillin/clavulanate in the treatment of subacute sinusitis and the prevention of recurrent infections in children. Allergol Immunopathol 1998; 26: 17-22.
17. Razi CH, Harmanci{dotless} K, Abaci A, et al. The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J Allergy Clin Immunol 2010; 126: 763-9.