Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake

Blood

Volumn 118, Issue 18, 2011, Pages 4967-4976

  Serbanovic Canic, Jovana ^a,b   Cvejic, Ana ^a,b   Soranzo, Nicole ^b   Stemple, Derek L ^b   Ouwehand, Willem H ^a,b   Freson, Kathleen ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSFERRIN;

ARTICLE; CELL MATURATION; CELL STRAIN K 562; CONTROLLED STUDY; ERYTHROID CELL; IRON DEFICIENCY ANEMIA; IRON TRANSPORT; MICROCYTIC ANEMIA; NONHUMAN; PRIORITY JOURNAL; ZEBRA FISH;

EID: 80855133515     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-02-337295     Document Type: Article

References (42)

1. Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008;132(4): 631-644. (Pubitemid 351260057)
2. Garner C, Tatu T, Reittie JE, et al. Genetic influences on F cells and other hematologic variables: a twin heritability study. Blood. 2000;95(1):342-346. (Pubitemid 30017262)
3. Evans DM, Frazer IH, Martin NG. Genetic and environmental causes of variation in basal levels of blood cells. Twin Res. 1999;2(4):250-257. (Pubitemid 30053332)
4. Soranzo N, Spector TD, Mangino M, et al. A genome- wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet. 2009;41(11): 1182-1190.
5. Ganesh SK, Zakai NA, van Rooij FJ, et al. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet. 2009;41(11): 1191-1198.
6. Benyamin B, Ferreira MAR, Willemsen G, et al. Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nat Genet. 2009;41(11):1173-1175.
7. Chambers JC, Zhang W, Li Y, et al. Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nat Genet. 2009;41(11):1170-1172.
8. Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol. 2005;21:247- 269.
9. Rossman KL, Der CJ, Sondek J. GEF means go: turning on RHO GTPases with guanine nucleotide- exchange factors. Nat Rev Mol Cell Biol. 2005;6(2):167-180. (Pubitemid 40215811)
10. Fukui Y, Hashimoto O, Sanui T, et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature. 2001; 412(6849):826-831. (Pubitemid 32801465)
11. Randall KL, Lambe T, Johnson A, et al. Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol. 2009;10(12):1283-1291.
12. Missy K, Hu B, Schilling K, et al. {alpha}PIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling. Mol Cell Biol. 2008;28(11):3776- 3789.
13. Fujikawa K, Miletic AV, Alt FW, et al. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med. 2003;198(10):1595- 1608.
14. Kourlas PJ, Strout MP, Becknell B, et al. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2000;97(5):2145-2150. (Pubitemid 30134036)
15. Francis SA, Shen X, Young JB, Kaul P, Lerner DJ. Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood. 2006;107(4):1627-1635. (Pubitemid 43242402)
16. Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J Biol Chem. 2002;277(45):42964-42972. (Pubitemid 35285675)
17. Watkins NA, Gusnanto A, de Bono B, et al. A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood. 2009; 113(19):1-9.
18. Mullin BH, Prince RL, Dick IM, et al. Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis. Am J Hum Genet. 2008; 82(6):1262-1269.
19. Traver D, Paw BH, Poss KD, Penberthy WT, Lin S, Zon LI. Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol. 2003;4(12):1238-1246. (Pubitemid 37540693)
20. Long Q, Meng A, Wang H, Jessen JR, Farrell MJ, Lin S. GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development. 1997;124(20):4105- 4111.
21. Lawson ND, Weinstein BM. In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol. 2002;248(2):307-318. (Pubitemid 35002091)
22. Westerfield M. The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Brachydanio rerio). Eugene, OR: University of Oregon Press; 1993.
23. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF. Stages of embryonic development of the zebrafish. Dev Dyn. 1995;203(3):253-310.
24. Thisse C, Thisse B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc. 2008;3(1):59-69.
25. Wingert RA, Brownlie A, Galloway JL, et al. The chianti zebrafish mutant provides a model for erythroid- specific disruption of transferrin receptor 1. Development. 2004;131(24):6225-6235. (Pubitemid 40123934)
26. Cvejic A, Serbanovic-Canic J, Stemple DL, Ouwehand WH. The role of meis1 in primitive and definitive hematopoiesis during zebrafish development. Haematologica. 2011;96(2):190-198.
27. Paddison PJ, Cleary M, Silva JM, et al. Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Meth. 2004;1(2):163-167.
28. Sun DQ, Melegari M, Sridhar S, Rogler CE, Zhu L. Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown. Biotechniques. 2006; 41(1):59-63. (Pubitemid 46534903)
29. Ibrahimi A, Velde GV, Reumers V, et al. Highly Efficient multicistronic lentiviral vectors with peptide sequences. Hum Gene Ther. 2009;20(8): 845-860.
30. Bertrand JY, Kim AD, Violette EP, Stachura DL, Cisson JL, Traver D. Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Development. 2007;134(23):4147-4156.
31. Frewin R, Henson A, Provan D. ABC of clinical haematology. Iron deficiency anaemia. Br Med J. 1997;314(7077):360-363. (Pubitemid 27056563)
32. Andrews NC. Disorders of iron metabolism. New Eng J Med. 1999;341(26):1986-1995. (Pubitemid 30010408)
33. Salas-Vidal E, Meijer AH, Cheng X, Spaink HP. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Genomics. 2005;86(1):25-37. (Pubitemid 40805333)
34. Andrews NC. Iron homeostasis: insights from genetics and animal models. Nat Rev Genet. 2000; 1(3):208-217.
35. Aisen P. Transferrin receptor 1. Int J Biochem Cell B. 2004;36(11):2137-2143. (Pubitemid 39094437)
36. Herbert SP, Huisken J, Kim TN, et al. Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science. 2009;326(5950):294-298.
37. Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet. 1999;21(4):396-399. (Pubitemid 29159576)
38. Kawabata H, Yang R, Hirama T, et al. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem. 1999;274(30):20826-20832.
39. Camaschella C, Roetto A, Cali A, et al. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet. 2000;25(1): 14-15. (Pubitemid 30257027)
40. Wallace DF, Summerville L, Subramaniam VN. Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Gastroenterology. 2007;132(1):301-310. (Pubitemid 46108757)
41. Symons M, Rusk N. Control of vesicular trafficking by Rho GTPases. Curr Biol. 2003;13(10): R409-418. (Pubitemid 36573246)
42. Garrick MD, Garrick LM. Loss of rapid transferrin receptor recycling due to a mutation in Sec15l1 in hbd mice. Biochim Biophys Acta. 2007;1773(2): 105-108. (Pubitemid 46123615)