Enforced bipedal downhill running induces Achilles tendinosis in rats

Connective Tissue Research

Volumn 52, Issue 6, 2011, Pages 466-471

  Ng, Gabriel Yin Fat ^a   Chung, Polly Yee Man ^a   Wang, Jenny Shijie ^b   Cheung, Roy Tsz Hei ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Achilles tendon; Degeneration; Downhill running; Strength; Tendinopathy

Indexed keywords

COLLAGEN;

ACHILLES TENDINITIS; ACHILLES TENDON; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CELL PROLIFERATION; CELL STRUCTURE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; ENFORCED BIPEDAL DOWNHILL RUNNING; EXPERIMENTAL DESIGN; EXPERIMENTAL TEST; FEMALE; HISTOPATHOLOGY; MUSCLE CELL; MUSCLE STIFFNESS; NONHUMAN; PROTEIN DEGRADATION; RAT; TENOCYTE; TREADMILL EXERCISE; VELOCITY;

ACHILLES TENDON; ANIMALS; BIOMECHANICS; FEMALE; HUMANS; RATS; RATS, SPRAGUE-DAWLEY; RUNNING; TENDINOPATHY;

ANIMALIA; RATTUS;

EID: 80855133401     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2011.562334     Document Type: Article

References (27)

1. Kettunen, J.A., Kujala, U.M., Kaprio, J., and Sarna, S. (2006). Health of master track and field athletes: A 16-year follow-up study. Clin. J. Sport. Med. 16:142-148. (Pubitemid 43670376)
2. Kujala, U.M., Sarna, S., and Kaprio, J. (2005). Cumulative incidence of Achilles tendon rupture and tendinopathy in male former elite athletes. Clin. J. Sport. Med. 15:133-135. (Pubitemid 40677155)
3. Silbernagel, K.G., Thomee, R., Eriksson, B.L., and Karlsson, J. (2007). Continued sports activity, using a pain-monitoring model, during rehabilitation in patients with Achilles tendinopathy - A randomized controlled study. Am. J. Sports. Med. 35(6):897-906. (Pubitemid 46956302)
4. Khan, K.M., Bonar, F., Desmond, P.M., Cook, J.L., Young, D.A., Visentini, P.J., Fehrmann, M.W., Kiss, Z.S., O'Brien, P.A., Harcourt, P.R., Dowling, R.J., O'Sullivan, R.M., Crichton, K.J., Tress, B.M., and Wark, J.D. (1996). Patellar tendinosis (jumper's knee): Findings at histopathologic examination, US and MR imaging. Radiology 200:821-827. (Pubitemid 26282288)
5. Riley, G. (2004). The pathogenesis of tendinopathy. A molecular perspective. Rheumatology 43:131-142.
6. Archambault, J.M., and Banes, A.J. (2005). Research methodology and animal modelling in tendinopathy. In Tendon Injuries, Basic Science and Clinical Medicine, N. Maffulli, P. Renström, and W.B. Leadbetter (eds.) pp. 281-282. London: Springer.
7. Fedorczky, J.M., Barr, A.E., Rani, S., Gao, H.G., Amin, M., Amin, S., Litvin, J., and Barbe, M.F. (2010). Exposuredependent increases in 1L-1b, Substance P, CTGF, and tendinosis in flexor digotorum tendons with upper extremity repetitive strain injury. J. Orthop. Res. 28:298-207.
8. Glazebrook, M.A., Wright, J.R., Langman, M., Stanish, W.D., and Lee, J.M. (2008). Histological analysis of Achilles tendons in an overuse rat model. J. Orthop. Res. 26:840-846.
9. Messner, K., Wei, Y., Andersson, B., Gillquist, J., and Räsänen, T. (1999). Rat model of Achilles tendon disorder. A pilot study. Cells Tissues Organs. 165:30-39. (Pubitemid 29398257)
10. Nakama, L.H., King, K.B., Abrahamsson, S., and Rempel, D.M. (2005). Evidence of tendon microtears due to cyclical loading in an in vivo tendinopathy model. J. Orthop. Res. 23(5):1199-1205. (Pubitemid 41245448)
11. Soslowsky, L.J., Thomopoulos, M.S., Tun, S., Flanagan, C.L., Keefer, C.C., Mastaw, J., and Carpenter, J.E. (2000). Overuse activity injures the supraspinatus tendon in an animal model: A histologic and biomechanical study. J. Shoulder Elbow Surg. 9:79-84.
12. Huang, T.F., Perry, S.M., and Soslowsky, L.J. (2004). The effect of overuse activity on Achilles tendon in an animal model: A biomechanical study. Ann. Biomed. Eng. 32(3):336-341.
13. Woo, S.L.Y., Orlando, C.A., Camp, J.F., and Akeson, W.H. (1986). Effects of postmortem storage by freezing on ligament tensile ligament behavior. J Biomech. 19(5):399-404. (Pubitemid 16091517)
14. Ng, G.Y.F., Oakes, B.W., McLean, I.D., Deacon, O.W., and Lampard, D. (1996). The long-term biomechanical and viscoelastic performance of repairing anterior cruciate ligament after hemitransection injury in a goat model. Am. J. Sports Med. 24(1):109-117. (Pubitemid 26036338)
15. Ng, G.Y.F., Fung, D.T.C., Leung, M.C.P., and Guo, X. (2004). Comparison of single and multiple applications of a therapeutic low energy laser for ligament repair. Lasers Surg. Med. 34(3):285-289. (Pubitemid 38420433)
16. See, E.K.N., Ng, G.Y.F., Ng, C.O.Y., and Fung, D.T.C. (2004). Running exercise improves the strength of partially ruptured tendo-achilles. Br. J. Sports Med. 38(5):597-600. (Pubitemid 39319212)
17. Fung, D.T.C., Ng, G.Y., Leung, M.C.P., and Tay, D.K.C. (2002). Therapeutic low energy laser improves the mechanical strength of repairing medial collateral ligament. Lasers Surg. Med. 31(2):91-96. (Pubitemid 34983112)
18. Ng, C.O.Y., Ng, G.Y.F., See, E.K.N., and Leung, M.C.P. (2003). Therapeutic ultrasound improves strength of Achilles tendon repair in rats. Ultrasound Med. Biol. 9(10):1501-1506. (Pubitemid 37338760)
19. Chan, H.K.F., Fung, D.T.C., and Ng, G.Y.F. (2007). Effects of low-voltage microamperage stimulation on tendon healing in rats. J. Orthop. Sports Phys. Ther. 37(7):399-403.
20. Warden, S.J. (2009). Development and use of animal models to advance tendinopathy research. Front. Biosci. 14:4588-4597.
21. Cook, J.L., Kiss, Z.S., Khan, K.M., Purdam, C.R., and Webster, K.E. (2004). Anthropometry, physical performance, and ultrasound patellar tendon abnormality in elite junior basketball players: A cross-sectional study. Br. J. Sports Med. 38:206-209. (Pubitemid 38446213)
22. Mahieu, N.N., Witvrouw, E., Stevens, V., Van Tiggelen, D., and Roget, P. (2006). Intrinsic risk factors for the development of Achilles tendon overuse injury: A prospective study. Am. J. Sports Med. 34:226-235. (Pubitemid 43152959)
23. Mokone, G.G., Schwellnus, M.P., Noakes, T.D., and Collins, M. (2006). The COL5A1 gene and Achilles tendon pathology. Scand J. Med. Sci. Sports. 16:19-26. (Pubitemid 43433301)
24. Witvrouw, E., Bellemans, J., Lysens, R., Danneels, L., and Cambier, D. (2001). Intrinsic risk factors for the development of patellar tendinitis in an athletic population. A two-year prospective study. Am. J. Sports Med. 29:190-195. (Pubitemid 32231033)
25. Reeves, N.D. (2006). Adaptation of the tendon to mechanical usage. J. Musculoskelet. Neuronal. Interact. 6:174-180. (Pubitemid 44193218)
26. Frost, H.M. (1990). Skeletal structural adaptations to mechanical usage (SATMU): 4. Mechanical influences on intact fibrous tissues. Anat. Rec. 226:433-439. (Pubitemid 20134043)
27. Cook, J.L., Feller, J.A., Bonar, S.F., and Khan, K.M. (2004). Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes' patellar tendons. J. Orthop. Res. 22:334-338. (Pubitemid 38155289)