Modeling the impact on the HIV epidemic of treating discordant couples with antiretrovirals to prevent transmission

AIDS

Volumn 25, Issue 18, 2011, Pages 2295-2299

  El Sadr, Wafaa M ^a   Coburn, Brian J ^b   Blower, Sally ^b  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antiretroviral therapy; infections prevented; mathematical modeling; prevention of HIV transmission

Indexed keywords

ANTIRETROVIRUS AGENT;

ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; GHANA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION CONTROL; LESOTHO; MAJOR CLINICAL STUDY; MALAWI; MALE; MATHEMATICAL MODEL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RWANDA; SEXUALITY; VIRUS TRANSMISSION;

ANTI-RETROVIRAL AGENTS; FAMILY CHARACTERISTICS; FEMALE; GHANA; HIV INFECTIONS; HUMANS; INCIDENCE; LESOTHO; MALAWI; MALE; MODELS, STATISTICAL; RISK FACTORS; RWANDA; SEXUAL PARTNERS;

EID: 80855132484     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32834c4c22     Document Type: Article

References (15)

1. UNAIDS Global Report 2010. http://www.unaids.org/globalre port/documents/20101123-GlobalReport-full-en.pdf. [Accessed 15 June 2011].
2. Siegfried N, Muller M, Deeks JJ, Volmink J. Male circumcision for prevention of heterosexual acquisition of HIV in men. Cochrane Database Syst Rev 2009; (2):CD003362.
3. Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010; 329:1168-1174; Epub 2010 Jul 19.
4. Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. Lancet 2009; 373:48-57.
5. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N. Prevention of HIV-1 Infection with Early Antiretroviral Therapy. N Engl J Med 2011; 365:493-505.
6. Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, Cohen CR, et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet 2010; 375:2092-2098; Epub 2010 May 26.
7. Reynolds SJ, Makumbi F, Nakigozi G, Kagaayi J, Gray RH, Wawer M, et al. HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy. AIDS 2011; 25:473-477.
8. Dunkle KL, Stephenson R, Karita E, Chomba E, Kayitenkore K, Vwalika C, et al. New heterosexually transmitted HIV infections in married or cohabiting couples in urban Zambia and Rwanda: an analysis of survey and clinical data. Lancet 2008; 371:2183-2191. (Pubitemid 351885039)
9. Gray R, Sempiija V, Shelton J, Serwadda D, Nalingoda F, Kagaayi J, et al. The contribution of HIV-discordant relationships to new HIV infections in Rakai, Uganda. AIDS 2011; 25:863-865.
10. Blower SM, Gershengorn HB, Grant RM. A tale of two futures: HIV and antiretroviral therapy in San Francisco. Science 2000; 287:650-654. (Pubitemid 30070912)
11. Velasco-Hernandez JX, Gershengorn HB, Blower SM. Could widespread use of combination antiretroviral therapy eradicate HIV epidemics?. Lancet Infect Dis 2002; 2:487-493. (Pubitemid 34826854)
12. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV-1 transmission: a mathematical model. Lancet 2009; 373:48-57.
13. Coburn BJ, Gerberry DJ, Blower S. Quantification of the role of discordant couples in driving incidence of HIV in sub-Saharan Africa. Lancet Infect Dis 2011; 11:263-264.
14. Eyawo O, de Walque D, Ford N, Gakii G, Lester RT, Mills EJ. HIV status in discordant couples in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Infect Dis 2010; 10:770-777.
15. Guthrie BL, de Bruyn G, Farquhar C. HIV-1-Discordant couples in sub-Saharan Africa: explanations and implications for high rates of discordancy. Curr HIV Res 2007; 5:416-429. (Pubitemid 47040483)