Integrating genetic studies of nicotine addiction into public health practice: Stakeholder views on challenges, barriers and opportunities

Public Health Genomics

Volumn 15, Issue 1, 2011, Pages 46-55

  Dingel, M J ^a   Hicks, A D ^b   Robinson, M E ^b   Koenig, B A ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Genetics; Individualized medicine; Nicotine addiction; Public health; Tobacco control

Indexed keywords

ARTICLE; ATTITUDE TO HEALTH; DRUG DEPENDENCE TREATMENT; DRUG INDUSTRY; HEALTH CARE DELIVERY; HEALTH CARE PERSONNEL; HEALTH CARE POLICY; HEALTH HAZARD; HEALTH INSURANCE; HEALTH PROGRAM; HUMAN; INTERVIEW; MEDICAL GENETICS; MEDICAL SPECIALIST; PERSONALIZED MEDICINE; PREVENTIVE MEDICINE; PRIORITY JOURNAL; PUBLIC HEALTH SERVICE; PUBLIC OPINION; QUALITATIVE ANALYSIS; SCIENTIST; SMOKING CESSATION; TOBACCO DEPENDENCE; TOBACCO INDUSTRY;

GENETIC PREDISPOSITION TO DISEASE; GENETIC SERVICES; HUMANS; PUBLIC HEALTH PRACTICE; TOBACCO INDUSTRY; TOBACCO USE DISORDER;

NICOTIANA TABACUM;

EID: 80855131449     PISSN: 16624246     EISSN: 16628063     Source Type: Journal    
DOI: 10.1159/000328861     Document Type: Article

References (67)

1. Berrettini W, Bierut L, Crowley TJ, Cubells JF, Frascella J, Gelernter J, Hewitt JK, Kreek MJ, Lachman H, Leppert M, Li MD, Madden P, Miner C, Pollock JD, Pomerleau O, Rice JP, Rutter JL, Shurtleff D, Swan GE, Tischfield JA, Tsuang M, Uhl GR, Vanyukov M, Volkow ND, Wanke K: Setting priorities for genomic research. Science 2004; 304: 1445-1446.
2. Bierut LJ, Cubells JF, Iacono WG, Li MD, Madden PA, Nelson EC, Pollock JD, Swan GE, Vanyukov M: Genetic research and smoking behavior. JAMA 2007; 297:809.
3. Carlsten C, Burke W: Potential for genetics to promote public health: genetics research on smoking suggests caution about expectations. JAMA 2006; 296: 2480-2482. (Pubitemid 44791205)
4. Carlsten C, Burke W: Reply to Bierut and colleagues. JAMA 2007; 297: 810.
5. Merikangas KR, Risch N: Genomic priorities a nd public health. Science 2003; 302: 599-601.
6. Merikangas KR, Risch N: Response. Science 2004; 304: 1446.
7. National Institute on Drug Abuse: Drugs, brains, and behavior: the science of addiction. Washington, D.C., National Institutes of Health, US Department of Health and Human Services, 2007. http://www.nida.nih.gov/ scienceofaddiction/sciofaddiction.pdf.
8. Seffrin JR, Myers ML, Brown NA, Healton C, Connor CD, Gould R: Letter to Dr. Francis Collins. http://www.apa.org/science/about/psa/2010/12/coliins- multiple.pdf (accessed April 4, 2011).
9. Collins FS: Shattuck lecture-medical and societal consequences of the human genome project. N Engl J Med 1999; 341: 28-37. (Pubitemid 29293718)
10. Varmus H: Ten years on-the human genome and medicine. N Engl J Med 2010; 362: 2028-2029.
11. Zhang B, Cohen J, Ferrence R, Rehm J: The impact of tobacco tax cuts on smoking initiation among Canadian young adults. Am J Prev Med 2006; 30: 474-479.
12. Chaloupka FJ, Wakefield M, Czart C: Taxing tobacco: the impact of tobacco taxes on cigarette smoking and other tobacco use; in Rabin RL, Sugarman SD (eds): Regulating Tobacco. New York, Oxford University Press, 2001, pp 39-71.
13. Jacobson PD, Zapawa LM: Clean indoor air restrictions: progress and promise; in Rabin R L, Sugarman SD (eds): Regulating Tobacco. New York, Oxford University Press, 2001, pp 207-244.
14. Ong MK, Zhou Q, Sung HY: Sensitivity to cigarette prices among individuals with alcohol, drug, or mentaldis orders. Am J Public Health 2010; 100:1243-1245.
15. Centers for Disease Control and Prevention: Cigarette smoking among adults and trends in smoking cessation-United States, 2008. Morb Mortal Wk ly Rep 2009; 58: 1227-1232.
16. Carmelli D, Swan G, Robinette D, Fabsitz R: Genetic influence on smoking-a study of ma le twins. N Engl J Med 1992; 327: 829-833.
17. Health A, Martin N: Genetic models for the natural-history of smoking: evidence for a genetic influence on smoking persistence. Addict Behav 1993; 18: 19-34. (Pubitemid 23080992)
18. Rao Y, Hoffmann E, Zia M, Bodin L, Zeman M, Sellers EM, Tyndale R: Duplications and defects in the CYP2A6 gene: identification, genotyping and in vivo effects on smoking. Mol Pharmacol 2000; 58: 747-755.
19. Munafò MR, Clark TG, Johnstone EC, Murphy MF, Walton RT: The genetic basis for smoking behavior: a systematic review and meta-analysis. Nicotine Tob Res 2004; 6: 583-597. (Pubitemid 39248145)
20. Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau O, Swan GE, Rutter J, Bertelsen S, Fox L, Fugman D, Goate AM, Hinrichs AL, Konvicka K, Martin NG, Montgomery GW, Saccone NL, Saccone SF, Wang JC, Chase GA, Rice JP, Ballinger DG: Novel genes identified in a high density genome wide association study for nicotine dependence. Hum Mol Genet 2006; 16: 24-35. (Pubitemid 46152542)
21. The Tobacco and Genetics Consortium: Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 2010; 42: 441-447.
22. Brand A, Brand H, Schultein den Baumen T: The impact of genetics and genomics on public health. Eur J Hum Genet 2008; 16:5-13. (Pubitemid 350269233)
23. Gwinn M, Guessous I, Khoury MJ: Invited commentary: genes, environment, and hybrid vigor. Am J Epidemiol 2009; 170:703-707.
24. National Cancer Institute: Phenotypes and endophenotypes: foundations for genetic studies of nicotine use and dependence. Bethesda, US Department of Health and Human Services, National Institutes of Health, National Cancer Institute, 2009.
25. Amos CI, Spitz MR, Cinciripini P: Chipping away at the genetics of smoking behavior. Nat Genet 2010; 42: 366-368.
26. Hall WD, Gartner CE, Carter A: The genetics of nicotine addiction liability: ethical and social policy implications. Addiction 2008; 103:350-359. (Pubitemid 351208094)
27. Khoury M J, Yang Q, Gwinn M, Little J, Dana Flanders W: An epidem iologic assessment of genomic profiling for measuring susceptibility to common diseases and targeting interventions. Genet Med 2004; 6:38-47. (Pubitemid 38175976)
28. Hudson K: The health benefits of genomics: out with the old, in with the new. Health Aff 2008; 27:1612-1615.
29. Hamburg MA, Collins FS: The path to personalized medicine. N Engl J Med 2010; 363: 301-304.
30. Khoury MJ, McBride C, Schully SD, Ionnidis JP, Feero WG, Janssens CJ, Gwinn M, Simons-Morton DG, Bernhardt JM, Cargill M, Chanock SJ, Church GM, Coates RJ, Collins FS, Croyle RT, Davis BR, Downing GJ, DuRoss A, Friedman S, Gail MH, Ginsburg GS, Green RC, Greene MH, Greenland P, Gulcher JR, Hsu A, Hudson KL, Kardia SL, Kimmel PL, Lauer MS, Miller AM, Offit K, Ransohoff DF, Roberts JS, Rasooly RS, Stefansson K, Terry SF, Teutsch SM, Trepanier A, Wanke KL, Witte JS, Xu J: The scientific foundation for personal genomics: recom mendations from a National Institutes of Health-Centers for Disease Control and Pre vention multidisciplinary workshop. Genet Med 2009; 11:559-567.
31. Khoury MJ, Gwinn M, Burke W, Bowen S, Zimmern R: Will genomics widen or help heal the schism between medicine and public health? Am J Prev Med 2007; 33:310-317. (Pubitemid 47405148)
32. Khoury MJ, Gwinn M, Yoon PW, Dowling N, Moore CA, Bradley LA: The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med 2007; 9: 665-674. (Pubitemid 350287151)
33. McBride C, Bowen D, Brody LC, Condit CM, Croyle RT, Gwinn M, Khoury MJ, Koehly LM, Korf BR, Marteau TM, McLeroy K, Patrick K, Valente T: Future health applications of genomics: priorities for communication, behavioral, and social sciences research. Am J Prev Med 2010; 38:556-561.
34. Rogowski WH, Grosse SD, Khoury MJ: Challenges of translating genetic tests into clinical and public health practice. Nat Rev Genet 2009; 10: 489-495.
35. Knoppers BM, Leroux T, Doucet H, Godard B, Laberge C, Stanton-Jean M, Fortin S, Cousineau J, Monardes C, Girard N, Levesque L, Durand C, Farmer Y, Dion-Labrie M, Bouthillier ME, Avard D: Framing genomics, public health research and policy: points to consider. Public Health Genomics 2010; 13: 224-234.
36. McBride C, Alford SH, Reid RJ, Larson EB, Baxevanis AD, Brody LC: Putting science over supposition in the area of personalized genomics. Nat Genet 2008; 40:939-942.
37. Hunter DJ, Khoury MJ, Drazen JM: Letting the genome out of the bottle-will we get our wish? N Engl J Med 2008; 358: 105-107.
38. Chen LS, Kwok OM, Goodson P: US health educators' likelihood of adopting genomic competencies into health promotion. Am J Public Health 2008; 98:1651-1657.
39. Bize R, Burnand B, Mueller Y, Rège Walther MR, Cornuz J: Biomedica l risk assessment as an aid for smoking cessation. Cochrane Database Syst Rev 2009;2:CD004705.
40. Carpenter MJ, Strange C, Jones Y, Dickson MR, Carter C, Moseley MA, Gilbert GE: Does genetic testing result in behavioral health change? Changes in smoking behavior following testing for alpha-1 antitrypsin deficiency. Ann Behav Med 2007; 33:22-28.
41. Hishida A, Terazawa T, Mamiya T, Ito H, Matsuo K, Tajima K, Hamajima N: Efficacy of genotype notification to Japanese smokers on smoking cessation-an intervention study at workplace. Cancer Epidemiol 2010; 34: 96-100.
42. McBride CM, Bepler G, Lipkus IM, Lyna P, Samsa G, Albright J, Datta S, Rimer BK: Incorporating genetic susceptibility feedback into a smoking cessation program for African-American smokers with low income. Cancer Epidemiol Biomarkers Prev 2002; 11: 521-528. (Pubitemid 34615158)
43. Sanderson SC, Humphries SE, Hubbart C, Hughes E, Jarvis M J, Wardle J: Psychological and behavioural impact of genetic testing smokers for lung cancer risk: a phase II ex-plorator y trial. J Health Psychol 2008; 13: 481-494. (Pubitemid 351537907)
44. Sanderson SC, O'Neill SC, White DB, Bepler G, Bastian L, Lipkus IM, McBride CM: Responses to online GSTM1 genetic test results among smokers related to patients with lung cancer: a pilot study. Cancer Epidemiol Bio-markers Prev 2009; 18: 1953-1961.
45. Gartner CE, Barendregt JJ, Hall WD: Multiple genetic tests for susceptibility to smoking do not outperform simple family history. Addiction 2009; 104:118-126.
46. Hall WD: Will nicotine genetics and a nicotine vaccine prevent cigarette smoking and smoking-related diseases? PLoS Med 2005; 2:e266.
47. Chen LS, Goodson P: Public health genomic knowledge and attitudes: a survey of public health educators in the United States. Genet Med 2007; 9: 496-503. (Pubitemid 47282037)
48. Foster MW, Mulvihill JJ, Sharp RR: Evaluating the utility of personal genomic information. Genet Med 2009; 11:570-574.
49. Bierut LJ, Cubells JF, Iacono WG, Li MD, Madden PA, Nelson EC, Pollock JD, Swan GE, Vanyukov M: Genetic research and smoking behavior. JAMA 2007; 297:809.
50. LaPelle NR, Zapka J, Ockene JK: Sustainabil-ity of public health programs: the example of tobacco treatment services in Massachusetts. Am J Public Health 2006; 96: 1363-1369. (Pubitemid 44261775)
51. Givel MS, Glantz SA: Failure to defend a successful state tobacco control program: policy lessons from Florida. Am J Public Health 2000; 90:762-767. (Pubitemid 30246380)
52. Anonymous: Money matters (editorial). Nat Med 2006; 12: 1331.
53. Menzies D: The case for a worldwide ban on smoking in public places. Curr Opin Pulm Med 2011; 17:116-122.
54. Hahn EJ: Smokefree legislation: a review of health and economic outcomes research. Am J Prev Med 2010; 39(6 suppl 1):S66-S76.
55. Marshall M: The key informant technique. Fam Pract 1996; 13: 92-97. (Pubitemid 26091420)
56. Patton MQ: Qualitative Research and Evaluation Methods, ed 3. Thousand Oaks, Sage Publications, 2002.
57. Patton MQ: How to Use Qualitative Methods in Evaluation. Beverly Hills, Sage Publications, 1987.
58. Corbin J, Strauss A: Grounded theory research: procedures, canons, and evaluative criteria. Qual Sociol 1990; 13: 3-21.
59. Corbin J, Strauss A: Basics of Qualitative Research, ed 3. Thousand Oaks, Sage Publications, 2008.
60. Farmer T, Robinson K, Elliott SJ, Eyles J: Developing and implementing a triangulation protocol for qualitative health research. Qual Health Res 2006; 16: 377-394. (Pubitemid 43263733)
61. Clarke AE: Situational Analysis: Grounded Theory after the Postmodern Turn. Thousand Oaks, Sage Publications, 2005.
62. Burke W, Laberge A-M, Press N: Debating clinical utility. Public Health Genomics 2010; 13: 215-223.
63. Conrad P, Schneider JW: Deviance and Med-icalization: From Badness to Sickness. Philadelphia, Temple University Press, 1992.
64. Schreiber R, Hartrick G: Keeping it together: how women use the biomedical explanatory model to manage the stigma of depression. Issues Ment Health Nurs 2002; 23: 91-105. (Pubitemid 33692375)
65. Jilek-Aall L, Jilek M, Kaaya J, Mkombachepa L, Hillary K: Psychosocial study of epilepsy in Africa. Soc Sci Med 1997; 45:783-795. (Pubitemid 27290507)
66. Gundle KR, Dingel MJ, Koenig BA: 'To prove this is the industry's best hope': big tobacco's support of research on the genetics of nicotine addiction. Addiction 2010; 105:974-983.
67. US Department of Health and Human Services: HHS region map. 2010. http://www. hhs.gov/about/regionmap.html.