The C0C1 fragment of human cardiac myosin binding protein C has common binding determinants for both actin and myosin

Journal of Molecular Biology

Volumn 413, Issue 5, 2011, Pages 908-913

  Lu, Yanling ^a   Kwan, Ann H ^a   Trewhella, Jill ^a   Jeffries, Cy M ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

C protein; heart muscle; MyBP C; NMR titration; small angle neutron scattering

Indexed keywords

ACTIN; F ACTIN; G ACTIN; MYOSIN; MYOSIN BINDING PROTEIN C; MYOSIN LIGHT CHAIN;

ACTIN FILAMENT; ARTICLE; HUMAN; NEUTRON SCATTERING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; TITRIMETRY;

EID: 80855128825     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.09.026     Document Type: Article

References (26)

1. Oakley C.E., Chamoun J., Brown L.J., and Hambly B.D. Myosin binding protein-C: enigmatic regulator of cardiac contraction Int. J. Biochem. Cell Biol. 39 2007 2161 2166 (Pubitemid 47484273)
2. Oakley C.E., Hambly B.D., Curmi P.M., and Brown L.J. Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy Cell Res. 14 2004 95 110
3. Hartzell H.C., and Titus L. Effects of cholinergic and adrenergic agonists on phosphorylation of a 165,000-dalton myofibrillar protein in intact cardiac muscle J. Biol. Chem. 257 1982 2111 2120 (Pubitemid 12146174)
4. Squire J.M., Luther P.K., and Knupp C. Structural evidence for the interaction of C-protein (MyBP-C) with actin and sequence identification of a possible actin-binding domain J. Mol. Biol. 331 2003 713 724 (Pubitemid 36937155)
5. Ababou A., Gautel M., and Pfuhl M. Dissecting the N-terminal myosin binding site of human cardiac myosin-binding protein C. Structure and myosin binding of domain C2 J. Biol. Chem. 282 2007 9204 9215 (Pubitemid 47093483)
6. Gruen M., and Gautel M. Mutations in beta-myosin S2 that cause familial hypertrophic cardiomyopathy (FHC) abolish the interaction with the regulatory domain of myosin-binding protein-C J. Mol. Biol. 286 1999 933 949 (Pubitemid 29106227)
7. Gruen M., Prinz H., and Gautel M. cAPK-phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin-S2 in an on-off fashion FEBS Lett. 453 1999 254 259 (Pubitemid 29326658)
8. Ratti J., Rostkova E., Gautel M., and Pfuhl M. Structure and interactions of myosin-binding protein C domain C0: cardiac-specific regulation of myosin at its neck? J. Biol. Chem. 286 2011 12650 12658
9. Rybakova I.N., Greaser M.L., and Moss R.L. Myosin binding protein C interaction with actin: characterization and mapping of the binding site J. Biol. Chem. 286 2011 2008 2016
10. Shaffer J.F., Kensler R.W., and Harris S.P. The myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive manner J. Biol. Chem. 284 2009 12318 12327
11. Whitten A.E., Jeffries C.M., Harris S.P., and Trewhella J. Cardiac myosin-binding protein C decorates F-actin: implications for cardiac function Proc. Natl Acad. Sci. USA 105 2008 18360 18365
12. Mun J.Y., Gulick J., Robbins J., Woodhead J., Lehman W., and Craig R. Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C) J. Mol. Biol. 410 2011 214 225
13. Luther P.K., Winkler H., Taylor K., Zoghbi M.E., Craig R., and Padron R. Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle Proc. Natl Acad. Sci. USA 108 2011 11423 11428
14. Kensler R.W., Shaffer J.F., and Harris S.P. Binding of the N-terminal fragment C0-C2 of cardiac MyBP-C to cardiac F-actin J. Struct. Biol. 174 2011 44 51
15. Orlova A., Galkin V.E., Jeffries C.M., Egelman E.H., and Trewhella J. The N-terminal domains of myosin binding protein C can bind polymorphically to F-actin J. Mol. Biol. 412 2011 379 386
16. Gautel M., Zuffardi O., Freiburg A., and Labeit S. Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction? EMBO J. 14 1995 1952 1960
17. Kunst G., Kress K.R., Gruen M., Uttenweiler D., Gautel M., and Fink R.H. Myosin binding protein C, a phosphorylation-dependent force regulator in muscle that controls the attachment of myosin heads by its interaction with myosin S2 Circ. Res. 86 2000 51 58 (Pubitemid 30044168)
18. Kulikovskaya I., McClellan G., Flavigny J., Carrier L., and Winegrad S. Effect of MyBP-C binding to actin on contractility in heart muscle J. Gen. Physiol. 122 2003 761 774 (Pubitemid 37517906)
19. Razumova M.V., Shaffer J.F., Tu A.Y., Flint G.V., Regnier M., and Harris S.P. Effects of the N-terminal domains of myosin binding protein-C in an in vitro motility assay: Evidence for long-lived cross-bridges J. Biol. Chem. 281 2006 35846 35854 (Pubitemid 46041316)
20. Saber W., Begin K.J., Warshaw D.M., and VanBuren P. Cardiac myosin binding protein-C modulates actomyosin binding and kinetics in the in vitro motility assay J. Mol. Cell. Cardiol. 44 2008 1053 1061
21. 2+ Biophys. J. 94 2008 293b
22. Shaffer J.F., Razumova M.V., Tu A.Y., Regnier M., and Harris S.P. Myosin S2 is not required for effects of myosin binding protein-C on motility FEBS Lett. 581 2007 1501 1504 (Pubitemid 46452626)
23. Shchepkin D.V., Kopylova G.V., Nikitina L.V., Katsnelson L.B., and Bershitsky S.Y. Effects of cardiac myosin binding protein-C on the regulation of interaction of cardiac myosin with thin filament in an in vitro motility assay Biochem. Biophys. Res. Commun. 401 2010 159 163
24. Ababou A., Rostkova E., Mistry S., Le Masurier C., Gautel M., and Pfuhl M. Myosin binding protein C positioned to play a key role in regulation of muscle contraction: structure and interactions of domain C1 J. Mol. Biol. 384 2008 615 630
25. Govada L., Carpenter L., da Fonseca P.C., Helliwell J.R., Rizkallah P., and Flashman E. Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy J. Mol. Biol. 378 2008 387 397
26. Delano W.L. The PyMOL Molecular Graphics System 2002 DeLano Scientific San Carlos, CA, USA