Time to put the CAR-T before the horse

Blood

Volumn 118, Issue 18, 2011, Pages 4761-4762

  Jacobson, Caron A ^a   Ritz, Jerome ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIBODY; CHIMERIC PROTEIN; CYCLOPHOSPHAMIDE; T LYMPHOCYTE RECEPTOR;

ACUTE LYMPHOCYTIC LEUKEMIA; ALLOGENEIC STEM CELL TRANSPLANTATION; APLASIA; B LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; FEVER; FIBROBLAST; HUMAN; NOTE; PRIORITY JOURNAL;

EID: 80855128786     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-09-376137     Document Type: Note

References (6)

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2. Eshhar Z, Waks T, Gross G, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T cell receptors. Proc Natl Acad Sci U S A. 1993;90(2):720-724. (Pubitemid 23028937)
3. Carpenito C, Milone MC, Hassan R, et al. Control of human T cells containing CD28 and CD137 domains. Proc Natl Acad Sci U S A. 2009;106(9):3360-3365.
4. Koehler P, Schmidt P, Hombach AA, Hallek M, Abken H. Engineered T cells for the adoptive therapy of B-cell chronic lymphocytic leukaemia. Adv Hematol. 2012;2012:595060.
5. Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011;365(8):725-733.
6. Kalos M, Levine BL, Porter DL, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Translational Med. 2011;3(95):95ra73.