Towards an extension of the two-variable model of carcinogenesis through oncogenes and tumour suppressor genes

Medical Hypotheses

Volumn 77, Issue 6, 2011, Pages 956-958

  Tourvas, Aristomenis Dimitrios ^a   Frangos, Constantinos C ^b  

^a LIMASSOL GENERAL HOSPITAL   (Cyprus)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MATRIX METALLOPROTEINASE; MICRORNA; MICRORNA 125B; MICRORNA 143; MICRORNA 145; MICRORNA 146A; MICRORNA 15; MICRORNA 155; MICRORNA 16; MICRORNA 17 5P; MICRORNA 196A; MICRORNA 205; MICRORNA 21; MICRORNA 217; MICRORNA 542 5P; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG; UVOMORULIN; VASCULOTROPIN;

3' UNTRANSLATED REGION; ANGIOGENESIS; ARTICLE; BREAST CANCER; CANCER INVASION; CARCINOGENESIS; DISEASE ASSOCIATION; DOWN REGULATION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENE SILENCING; HUMAN; LUNG CANCER; LYMPHATIC LEUKEMIA; MANTLE CELL LYMPHOMA; NEUROBLASTOMA; ONCOGENE; ONCOGENE C MYC; PANCREAS CANCER; PROSTATE CANCER; PROTEIN EXPRESSION; RNA ANALYSIS; SIGNAL TRANSDUCTION; THYROID CARCINOMA; TUMOR SUPPRESSOR GENE; UPREGULATION;

CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; MICRORNAS; MODELS, BIOLOGICAL; ONCOGENES;

EID: 80755189027     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2011.08.017     Document Type: Article

References (20)

1. Huang Y., Shen X.J., Zou Q., Wang S.P., Tang S.M., Zhang G.Z. Biological functions of microRNAs: a review. J Physiol Biochem 2011, 67:129-139.
2. Gartel A.L., Kandel E.S. MiRNAs: Little known mediators of oncogenesis. Semin Cancer Biol 2008, 18:103-110.
3. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
4. Dalmay T., Edwards D.R. MicroRNAs and the hallmarks of cancer. Oncogene 2006, 25:6170-6175.
5. Calin G.A., Dumitru C.D., Shimizu M., et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002, 99:15524-15529.
6. Shi X.B., Xue L., Yang J., et al. An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proc Natl Acad Sci U S A 2007, 104:19983-19988.
7. Xu Y., Fang F., Zhang J., Josson S., St Clair W.H., St Clair D.K. MiR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes. PLoS One 2010, 5:e14356.
8. Volinia S., Calin G.A., Liu C.G., et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 2006, 103:2257-2261.
9. Park J.Y., Helm J., Coppola D., Kim D., Malafa M., Kim S.J. MicroRNAs in pancreatic ductal adenocarcinoma. World J Gastroenterol 2011, 17:817-827.
10. Iorio M.V., Ferracin M., Liu C.G., et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005, 65:7065-7070.
11. Yanaihara N., Caplen N., Bowman E., et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006, 9:189-198.
12. Liu C.G., Calin G.A., Meloon B., et al. An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci U S A 2004, 101:9740-9744.
13. Akagi I, Miyashita M, Ishibashi O, et al. Relationship between altered expression levels of MIR21, MIR143, MIR145, and MIR205 and clinicopathologic features of esophageal squamous cell carcinoma. Dis Esophagus 2011.
14. Jazdzewski K., Boguslawska J., Jendrzejewski J., et al. Thyroid hormone receptor beta (THRB) is a major target gene for microRNAs deregulated in papillary thyroid carcinoma (PTC). J Clin Endocrinol Metab 2011, 96:E546-553.
15. Bray I., Tivnan A., Bryan K., et al. MicroRNA-542-5p as a novel tumor suppressor in neuroblastoma. Cancer Lett 2011, 303:56-64.
16. Tan H.X., Wang Q., Chen L.Z., et al. MicroRNA-9 reduces cell invasion and E-cadherin secretion in SK-Hep-1 cell. Med Oncol 2010, 27:654-660.
17. Ma L., Young J., Prabhala H., et al. MiR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010, 12:247-256.
18. He L., Thomson J.M., Hemann M.T., et al. A microRNA polycistron as a potential human oncogene. Nature 2005, 435:828-833.
19. Lu J., Getz G., Miska E.A., et al. MicroRNA expression profiles classify human cancers. Nature 2005, 435:834-838.
20. Aguda B.D., Kim Y., Piper-Hunter M.G., Friedman A., Marsh C.B. MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc. Proc Natl Acad Sci U S A 2008, 105:19678-19683.