Efficacy of a combined oral clindamycin-rifampicin regimen for therapy of staphylococcal osteoarticular infections

Scandinavian Journal of Infectious Diseases

Volumn 43, Issue 11-12, 2011, Pages 962-967

  Czekaj, Jaroslaw ^a   Dinh, Aurélien ^b   Moldovan, Andreea ^a   Vaudaux, Pierre ^a   Gras, Guillaume ^c   Hoffmeyer, Pierre ^a   Lew, Daniel ^a   Bernard, Louis ^a,b,c   Uçkay, Ilker ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^c UNIVERSITÉ DE TOURS   (France)

Author keywords

Clindamycin; Combination therapy; Infection; Osteoarticular infection; Rifampicin

Indexed keywords

CLINDAMYCIN; RIFAMPICIN;

ADOLESCENT; ADULT; AGED; ANTIMICROBIAL THERAPY; ARTHRITIS; ARTHROPATHY; ARTICLE; BONE INFECTION; CLINICAL ARTICLE; COXITIS; FEMALE; FOLLOW UP; HIP ARTHROPLASTY; HUMAN; INTERVERTEBRAL DISK DEGENERATION; KNEE ARTHROPLASTY; MALE; OSTEOMYELITIS; PROSTHESIS INFECTION; RETROSPECTIVE STUDY; SHOULDER DISEASE; STAPHYLOCOCCAL OSTEOARTICULAR INFECTION; STAPHYLOCOCCUS INFECTION; TREATMENT DURATION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CLINDAMYCIN; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS; PROSTHESIS-RELATED INFECTIONS; RIFAMPIN; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 80755171264     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2011.608082     Document Type: Article

References (35)

1. U ç kay I, Laurent F, Lustig S, Rasigade, JP, Thompson V, Paoli V, et al. Hospital and community-acquired methicillinresistant Staphylococcus aureus bone and joint infections. In: Charles L. Kolendi, editor. New York: Nova Science Publishers; 2009. p. 143-209.
2. Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med 2004;351:1645-54.
3. U ç kay I, Pittet D, Vaudaux P, Sax H, Lew D, Waldvogel F. Foreign body infections due to Staphylococcus epidermidis. Ann Med 2009;41:109-19.
4. Lew DP, Waldvogel FA. Osteomyelitis. Lancet 2004;364: 369-79.
5. Trampuz A, Zimmerli W. Antimicrobial agents in orthopaedic surgery: prophylaxis and treatment. Drugs 2006;66: 1089-105. (Pubitemid 43945869)
6. Del Pozo JL, Patel R. Clinical practice. Infection associated with prosthetic joints. N Engl J Med 2009;361:787-94.
7. U ç kay I, Lew D. Infections in skeletal prostheses. In: William R. Jarvis, editor. Bennet & Brachman ' s hospital infections. 5 th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2007. p. 665- 72.
8. Perlroth J, Kuo M, Tan J, Bayer AS, Miller LG. Adjunctive use of rifampin for the treatment of Staphylococcus aureus infections: A systematic review of the literature. Arch Intern Med 2008;168:805-19. (Pubitemid 351620083)
9. Hackbarth CJ, Chambers HF, Sande MA. Serum bactericidal activity of rifampin in combination with other antimicrobial agents against Staphylococcus aureus. Antimicrob Agents Chemother 1986;29:611-3. (Pubitemid 16106381)
10. Arditi M, Yogev R. In vitro interaction between rifampin and clindamycin against pathogenic coagulase-negative staphylococci. Antimicrob Agents Chemother 1989;33:245-7. (Pubitemid 19053869)
11. Feigin RD, Pickering LK, Anderson D, Keeney RE, Shackleford PG. Clindamycin treatment of osteomyelitis and septic arthritis in children. Pediatrics 1975;55:213-23.
12. El Samad Y, Havet E, Bentayeb H, Olory B, Canarelli B, Lardanchet JF, et al. Treatment of osteoarticular infections with clindamycin in adults. Med Mal Infect 2008;38: 465-70.
13. Zeller V, Dzeing-Ella A, Kitzis MD, Ziza JM, Mamoudy P, Desplaces N. Continuous clindamycin infusion, an innovative approach to treating bone and joint infections. Antimicrob Agents Chemother 2010;54:88-92.
14. Ho JL, Klempner MS. In vitro evaluation of clindamycin in combination with oxacillin, rifampin, or vancomycin against Staphylococcus aureus. Diagn Microbiol Infect Dis 1986;4:133-8. (Pubitemid 16036592)
15. Renneberg J, Karlsson E, Nilsson B, Walder M. Interactions of drugs acting against Staphylococcus aureus in vitro and in a mouse model. J Infect 1993;26:265-77. (Pubitemid 23177546)
16. O' R eilly T, Kunz S, Sande E, Zak O, Sande MA, Täu ber MG. Relationship between antibiotic concentration in bone and effi cacy of treatment of staphylococcal osteomyelitis in rats: Azithromycin compared with clindamycin and rifampin. Antimicrob Agents Chemother 1992;36:2693-7.
17. Phillips I. Clinical uses and control of rifampicin and clindamycin. J Clin Pathol 1971;24:410-8.
18. Dhawan VK, Thadepalli H. Clindamycin: A review of fi fteen years of experience. Rev Infect Dis 1982;4:1133-53.
19. Srinivasan S, Sheela D, Mathew R, Bazroy J, Kanungo R. Risk factors and associated problems in the management of infections with methicillin-resistant Staphylococcus aureus. Indian J Med Microbiol 2006;24:182-5. (Pubitemid 44315650)
20. Mitchell PD, Hunt DM, Lyall H, Nolan M, Tudor-Williams G. Panton - Valentine leukocidin-secreting Staphylococcus aureus causing severe musculoskeletal sepsis in children. A new threat. J Bone Joint Surg 2007;89:1239-42. (Pubitemid 350057964)
21. Gener G, Canoui-Poitrine F, Revuz JE, Faye O, Poli F, Gabison G, et al. Combination therapy with clindamycin and rifampicin for hidradenitis suppurativa: A series of 116 consecutive patients. Dermatology 2009;219:148-54.
22. van der Zee HH, Boer J, Prens EP, Jemec GB. The effect of combined treatment with oral clindamycin and oral rifampicin in patients with hidradenitis suppurativa. Dermatology 2009;219:143-7.
23. Franç ois P, Harbarth S, Huyghe A, Renzi G, Bento M, Gervaix A, et al. Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993 - 2005. Emerg Infect Dis 2008; 14:304-7.
24. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 17 th Informational supplement. M100-S17. Wayne PA: CLSI; 2007.
25. Svensson E, Hanberger H, Nilsson LE. Pharmacodynamic effects of antibiotics and antibiotic combinations on growing and nongrowing Staphylococcus epidermidis cells. Antimicrob Agents Chemother 1997;41:107-11. (Pubitemid 26428142)
26. Hellmark B, Unemo M, Nilsdotter-Augustinsson A, Sö derquist B. In vitro antimicrobial synergy testing of coagulase-negative staphylococci isolated from prosthetic joint infections using E-test and with a focus on rifampicin and linezolid. Eur J Clin Microbiol Infect Dis 2010; 29:591-5.
27. Soriano A, Gó m ez J, Gó m ez L, Azanza JR, Pé rez R, Romero F, et al. Effi cacy and tolerability of prolonged linezolid therapy in the treatment of orthopedic implant infections. Eur J Clin Microbiol Infect Dis 2007;26:353-6. (Pubitemid 46716796)
28. Berdal JE, Skrå m m I, Mowinckel P, Gulbrandsen P, Bjø rnholt JV. Use of rifampicin and ciprofl oxacin combination therapy after surgical debridement in the treatment of early manifestation prosthetic joint infections. Clin Microbiol Infect 2005;11:843-5. (Pubitemid 41341720)
29. Zimmerli W, Widmer AF, Blatter M, Frei R, Ochsner PE. Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: A randomized controlled trial. JAMA 1998;279:1537-41. (Pubitemid 28233008)
30. Soriano A, García S, Bori G, Almela M, Gallart X, Macule F, et al. Treatment of acute post-surgical infection of joint arthroplasty. Clin Microbiol Infect 2006;12:930-3. (Pubitemid 44151298)
31. Aboltins CA, Page MA, Buising KL, Jenney AW, Daffy JR, Choong PF, et al. Treatment of staphylococcal prosthetic joint infections with debridement, prosthesis retention and oral rifampicin and fusidic acid. Clin Microbiol Infect 2007; 13:586-91. (Pubitemid 46730664)
32. Antony SJ. Combination therapy with daptomycin, vancomycin, and rifampin for recurrent, severe bone and prosthetic joint infections involving methicillin-resistant Staphylococcus aureus. Scand J Infect Dis 2006;38:293-5.
33. Burns CA. Daptomycin- rifampin for a recurrent MRSA joint infection unresponsive to vancomycin-based therapy. Scand J Infect Dis 2006;38:133-6. (Pubitemid 43203242)
34. Gagnon RF, Richards GK, Kostiner GB. Time-kill effi cacy of antibiotics in combination with rifampin against Staphylococcus epidermidis biofi lms. Adv Perit Dial 1994;10:189-92.
35. U ç kay I, Assal M, Legout L, Rohner P, Stern R, Lew D, et al. Recurrent osteomyelitis caused by infection with different bacterial strains without obvious source of reinfection. J Clin Microbiol 2006;44:1194-6.