Does long-course radiotherapy influence postoperative perineal morbidity after abdominoperineal resection of the rectum for cancer?

Colorectal Disease

Volumn 13, Issue 12, 2011, Pages 1407-1412

  Zorcolo, L ^a   Restivo, A ^a   Capra, F ^a,b   Fantola, G ^a   Marongiu, L ^a   Casula, G ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b Nuova Casa di Cura Decimomannu   (Italy)

Author keywords

Abdominoperineal resection; Neoadjuvant therapy; Perineal wound complications; Radiotherapy; Rectal cancer

Indexed keywords

ANTINEOPLASTIC AGENT;

ADULT; AGED; ARTICLE; BODY MASS; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; FEMALE; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; PERINEUM INJURY; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM CANCER; RISK FACTOR; WOUND HEALING; WOUND INFECTION;

ABDOMEN; ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; PERINEUM; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; SURGICAL WOUND DEHISCENCE; SURGICAL WOUND INFECTION; WOUND HEALING;

EID: 80755167673     PISSN: 14628910     EISSN: 14631318     Source Type: Journal    
DOI: 10.1111/j.1463-1318.2010.02536.x     Document Type: Article

References (29)

1. Lange MM, Rutten HJ, van de Velde CJ. One hundred years of curative surgery for rectal cancer: 1908-2008. Eur J Surg Oncol 2009; 35: 456-63.
2. Kapiteijn E, Marijnen CA, Nagtegaal ID et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001; 345: 638-46.
3. Roh MS, Colangelo LH, O'Connell MJ et al. Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03. J Clin Oncol 2009; 27: 5124-30.
4. Sauer R, Becker H, Hohenberger W et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004; 351: 1731-40.
5. Crane CH, Skibber JM, Feig BW et al. Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma. Cancer 2003; 97: 517-24.
6. Weiser M, Quah H, Shia J et al. Sphincter preservation in low rectal cancer is facilitated by preoperative chemoradiation and intersphincteric dissection. Ann Surg 2009; 249: 236-42.
7. Pollard CW, Nivatvongs S, Rojanasakul A et al. Carcinoma of the rectum. Profiles of intraoperative and early postoperative complications. Dis Colon Rectum 1994; 37: 866-74.
8. Rosen L, Veidenheimer MC, Coller JA et al. Mortality, morbidity, and patterns of recurrence after abdominoperineal resection for cancer of the rectum. Dis Colon Rectum 1982; 25: 202-8.
9. Rothenberger D, Wong W. Abdominoperineal resection for adenocarcinoma of the low rectum. World J Surg 1992; 16: 478-85.
10. Bullard KM, Trudel JL, Baxter NN et al. Primary perineal wound closure after preoperative radiotherapy and abdominoperineal resection has a high incidence of wound failure. Dis Colon Rectum 2005; 48: 438-43.
11. Christian CK, Kwaan MR, Betensky RA et al. Risk factors for perineal wound complications following abdominoperineal resection. Dis Colon Rectum 2005; 48: 43-8.
12. Horan TC, Gaynes RP, Martone WJ et al. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Am J Infect Control 1992; 20: 271-4.
13. Artioukh DY, Smith RA, Gokul K. Risk factors for impaired healing of the perineal wound after abdominoperineal resection of rectum for carcinoma. Colorectal Dis 2007; 9: 362-7.
14. Glimelius B, Pahlman L. Perioperative radiotherapy in rectal cancer. Acta Oncol 1999; 38: 23-32.
15. Johnson LB, Jorgensen LN, Adawi D et al. The effect of preoperative radiotherapy on systemic collagen deposition and postoperative infective complications in rectal cancer patients. Dis Colon Rectum 2005; 48: 1573-80.
16. Plowman PN. The effects of conventionally fractionated, extended portal radiotherapy on the human peripheral blood count. Int J Radiat Oncol Biol Phys 1983; 9: 829-39.
17. Gabka CJ, Benhaim P, Mathes SJ et al. An experimental model to determine the effect of irradiated tissue on neutrophil function. Plast Reconstr Surg 1995; 96: 1676-88.
18. Denham JW, Hauer-Jensen M. The radiotherapeutic injury - a complex 'wound'. Radiother Oncol 2002; 63: 129-45.
19. von Smitten K, Sundell B. The impact of adjuvant radiotherapy and cytotoxic chemotherapy on the outcome of immediate breast reconstruction by tissue expansion after mastectomy for breast cancer. Eur J Surg Oncol 1992; 18: 119-23.
20. Seifert WF, Wobbes T, Hoogenhout J et al. Intraoperative irradiation delays anastomotic repair in rat colon. Am J Surg 1995; 170: 256-61.
21. Pahlman L, Glimelius B. Pre- or postoperative radiotherapy in rectal and rectosigmoid carcinoma. Report from a randomized multicenter trial. Ann Surg 1990; 211: 187-95.
22. MRCRC Working Party. Randomised trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cancer. Medical Research Council Rectal Cancer Working Party. Lancet 1996; 348: 1605-10.
23. Kerr S, Norton S, Glynne-Jones R. Delaying surgery after neoadjuvant chemoradiotherapy for rectal cancer may reduce postoperative morbidity without compromising prognosis. Br J Surg 2008; 95: 1534-40.
24. Chadwick MA, Vieten D, Pettitt E et al. Short course preoperative radiotherapy is the single most important risk factor for perineal wound complications after abdominoperineal excision of the rectum. Colorectal Dis 2006; 8: 756-61.
25. Nissan A, Guillem JG, Paty PB et al. Abdominoperineal resection for rectal cancer at a specialty center. Dis Colon Rectum 2001; 44: 27-35. discussion 35-26.
26. El-Gazzaz G, Kiran RP, Lavery I. Wound complications in rectal cancer patients undergoing primary closure of the perineal wound after abdominoperineal resection. Dis Colon Rectum 2009; 52: 1962-6.
27. Groszek DM. Promoting wound healing in the obese patient. AORN J 1982; 35: 1132-8.
28. Armstrong M. Obesity as an intrinsic factor affecting wound healing. J Wound Care 1998; 7: 220-1.
29. Chang DW, Wang B, Robb GL et al. Effect of obesity on flap and donor-site complications in free transverse rectus abdominis myocutaneous flap breast reconstruction. Plast Reconstr Surg 2000; 105: 1640-8.