Extraction socket healing in rats treated with bisphosphonate: Animal model for bisphosphonate related osteonecrosis of jaws in multiple myeloma patients

Medicina Oral, Patologia Oral y Cirugia Bucal

Volumn 16, Issue 7, 2011, Pages

  Ali Erdem, Mehmet ^a   Burak Cankaya, Abdulkadir ^a   Cemil Isler, Sabri ^a   Demircan, Sabit ^a   Soluk, Merva ^a   Kasapoglu, Cetin ^a   Korhan Oral, Cuneyt ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Bisphosphonate; Extraction socket; Osteonecrosis; Rat

Indexed keywords

DEXAMETHASONE; ZOLEDRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; CORTICOSTEROID THERAPY; JAW OSTEONECROSIS; MALE; MANDIBLE; MAXILLA; MOLAR TOOTH; MULTIPLE MYELOMA; NONHUMAN; OSSIFICATION; RAT; TOOTH EXTRACTION; WOUND HEALING;

ANIMALS; BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS OF THE JAW; DIPHOSPHONATES; DISEASE MODELS, ANIMAL; HUMANS; MALE; MULTIPLE MYELOMA; RATS; RATS, WISTAR; TOOTH EXTRACTION; TOOTH SOCKET; WOUND HEALING;

EID: 80755141279     PISSN: 16984447     EISSN: 16986946     Source Type: Journal    
DOI: 10.4317/medoral.17150     Document Type: Article

References (21)

1. Rogers MJ, Watts DJ, Russell RG. Overview of bisphosphonates. Cancer. 1997;80:1652-60.
2. Coleman RE. Future directions in the treatment and prevention of bone metastases. Am J Clin Oncol. 2002;25:S32-8.
3. Holen I, Coleman RE. Bisphosphonates as treatment of bone metastases. Curr Pharm Des. 2010;16:1262-71.
4. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61:1115-7.
5. Hansen T, Kunkel M, Weber A, James Kirkpatrick C. Osteonecrosis of the jaws in patients treated with bisphosphonates - histomorphologic analysis in comparison with infected osteoradionecrosis. J Oral Pathol Med. 2006;35:155-60.
6. Flichy-Fernández AJ, Balaguer-Martínez J, Peñarrocha-Diago M, Bagán JV. Bisphosphonates and dental implants: current problems. Med Oral Patol Oral Cir Bucal. 2009;14:E355-60.
7. Marx RE, Cillo JE Jr, Ulloa JJ. Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J Oral Maxillofac Surg. 2007;65:2397-410.
8. Pérez SB, Barrero MV, Hernández MS, Knezevic M, Navarro JM, Millares JR. Bisphosphonate-associated osteonecrosis of the jaw. A proposal for conservative treatment. Med Oral Patol Oral Cir Bucal. 2008;13:E770-3.
9. Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg. 2004;62:527-34.
10. Mashiba T, Hirano T, Turner CH, Forwood MR, Johnston CC, Burr DB. Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. J Bone Miner Res. 2000;15:613-20.
11. Zaki Ae, Vanhuysen G. Histology of the periodontium following tooth movement. J Dent Res. 1963;42:1373-9.
12. Rygh P. Ultrastructural changes in pressure zones of human periodontium incident to orthodontic tooth movement. Acta Odontol Scand. 1973;31:109-22.
13. Wood J, Bonjean K, Ruetz S, Bellahcène A, Devy L, Foidart JM, et al. Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther. 2002;302:1055-61.
14. Fournier P, Boissier S, Filleur S, Guglielmi J, Cabon F, Colombel M, et al. Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. Cancer Res. 2002;62:6538-44.
15. Pietrokovski J, Massler M. Ridge remodeling after tooth extraction in rats. J Dent Res. 1967;46:222-31.
16. Johansen JR. Repair of the post-extraction alveolus in the Wistar rat. A histologic and autoradiographic study. Acta Odontol Scand. 1970;28:441-61.
17. Hikita H, Miyazawa K, Tabuchi M, Kimura M, Goto S. Bisphosphonate administration prior to tooth extraction delays initial healing of the extraction socket in rats. J Bone Miner Metab. 2009;27:663-72.
18. Yamamoto Y, Udagawa N, Matsuura S, Nakamichi Y, Horiuchi H, Hosoya A, et al. Osteoblasts provide a suitable microenvironment for the action of receptor activator of nuclear factor-kappaB ligand. Endocrinology. 2006;147:3366-74.
19. Tabuchi M, Miyazawa K, Kimura M, Maeda H, Kawai T, Kameyama Y, et al. Enhancement of crude bone morphogenetic protein-induced new bone formation and normalization of endochondral ossification by bisphosphonate treatment in osteoprotegerin-deficient mice. Calcif Tissue Int. 2005;77:239-49.
20. Reid IR, Bolland MJ, Grey AB. Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity? Bone. 2007;41:318-20.
21. Sonis ST, Watkins BA, Lyng GD, Lerman MA, Anderson KC. Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients. Oral Oncol. 2009;45:164-72.