55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation

Biochemical and Biophysical Research Communications

Volumn 415, Issue 1, 2011, Pages 75-81

  Kageyama, Maiko ^a   Takahasi, Kiyohiro ^a   Narita, Ryo ^a   Hirai, Reiko ^a,b   Yoneyama, Mitsutoshi ^a,b,c   Kato, Hiroki ^a   Fujita, Takashi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Interferon; RIG I; Virus

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALANINE; HELICASE; INTERFERON; RETINOIC ACID INDUCIBLE PROTEIN I; TRYPSIN; VIRUS RNA;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; HUMAN; INTERFERON PRODUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA BINDING; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; DEAD-BOX RNA HELICASES; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RNA;

EID: 80755140529     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.10.015     Document Type: Article

References (23)

1. Loo Y.M., Gale M. Immune signaling by RIG-I-like receptors. Immunity 2011, 34:680-692.
2. Schlee M., Hartmann G. The chase for the RIG-I ligand-recent advances. Mol. Ther. 2010, 18:1254-1262.
3. Takeuchi O., Akira S. Innate immunity to virus infection. Immunol. Rev. 2009, 227:75-86.
4. Yoneyama M., Fujita T. Recognition of viral nucleic acids in innate immunity. Rev. Med. Virol. 2010, 20:4-22.
5. Yoneyama M., Kikuchi M., Natsukawa T., Shinobu N., Imaizumi T., Miyagishi M., Taira K., Akira S., Fujita T. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 2004, 5:730-737.
6. Yoneyama M., Kikuchi M., Matsumoto K., Imaizumi T., Miyagishi M., Taira K., Foy E., Loo Y.M., Gale M., Akira S., Yonehara S., Kato A., Fujita T. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J. Immunol. 2005, 175:2851-2858.
7. Hornung V., Ellegast J., Kim S., Brzózka K., Jung A., Kato H., Poeck H., Akira S., Conzelmann K.K., Schlee M., Endres S., Hartmann G. 5'-Triphosphate RNA is the ligand for RIG-I. Science 2006, 314:994-997.
8. Pichlmair A., Schulz O., Tan C.P., Näslund T.I., Liljeström P., Weber F., Reis e Sousa C. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science 2006, 314:997-1001.
9. Saito T., Hirai R., Loo Y., Owen D., Johnson C., Sinha S., Akira S., Fujita T., Gale M.J. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Natl. Acad. Sci. USA 2007, 104:582-587.
10. Takahasi K., Yoneyama M., Nishihori T., Hirai R., Kumeta H., Narita R., Gale M.J., Inagaki F., Fujita T. Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol. Cell 2008, 29:428-440.
11. Cui S., Eisenächer K., Kirchhofer A., Brzózka K., Lammens A., Lammens K., Fujita T., Conzelmann K., Krug A., Hopfner K. The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol. Cell 2008, 29:169-179.
12. Kawai T., Takahashi K., Sato S., Coban C., Kumar H., Kato H., Ishii K., Takeuchi O., Akira S. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 2005, 6:981-988.
13. Seth R.B., Sun L., Ea C.K., Chen Z.J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 2005, 122:669-682.
14. Xu L.G., Wang Y.Y., Han K.J., Li L.Y., Zhai Z., Shu H.B. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell 2005, 19:727-740.
15. Meylan E., Curran J., Hofmann K., Moradpour D., Binder M., Bartenschlager R., Tschopp J. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 2005, 437:1167-1172.
16. Honda K., Takaoka A., Taniguchi T. Type I interferon gene induction by the interferon regulatory factor family of transcription factors. Immunity 2006, 25:349-360.
17. Thompson J.D., Gibson T.J., Plewniak F., Jeanmougin F., Higgins D.G. The CLUSTAL_X windows interface. flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 1997, 25:4876-4882.
18. Combet C., Blanchet C., Geourjon C., Deléage G. NPS@: network protein sequence analysis. Trends Biochem. Sci. 2000, 25:147-150.
19. Iwamura T., Yoneyama M., Yamaguchi K., Suhara W., Mori W., Shiota K., Okabe Y., Namiki H., Fujita T. Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells 2001, 6:375-388.
20. Kato H., Sato S., Yoneyama M., Yamamoto M., Uematsu S., Matsui K., Tsujimura T., Takeda K., Fujita T., Takeuchi O., Akira S. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005, 23:19-28.
21. Gack M., Shin Y., Joo C., Urano T., Liang C., Sun L., Takeuchi O., Akira S., Chen Z., Inoue S., Jung J. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 2007, 446:916-920.
22. T. Shigemoto, M. Kageyama, R. Hirai, J. Zheng, M. Yoneyama, T. Fujita, Identification of loss of function mutations in human genes encoding RIG-I and mda5: Implications for resistance to type I diabetes, J. Biol. Chem. (2009).
23. Oshiumi H., Miyashita M., Inoue N., Okabe M., Matsumoto M., Seya T. The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection. Cell Host Microbe 2010, 8:496-509.