Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells

Molecular and Cellular Endocrinology

Volumn 348, Issue 1, 2012, Pages 165-175

  Lucki, Natasha C ^a   Li, Donghui ^b   Sewer, Marion B ^b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Acute steroidogenesis; Cortisol; H295R; Sphingosine 1 phosphate; StAR

Indexed keywords

CALCIUM ION; CALMODULIN DEPENDENT KINASE 2; CARRIER PROTEIN; CHOLESTEROL; GUANINE NUCLEOTIDE BINDING PROTEIN; HORMONE SENSITIVE LIPASE; HYDROCORTISONE; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C; SCAVENGER RECEPTOR BI; SPHINGOSINE 1 PHOSPHATE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG;

ADRENAL CORTEX CELL; ARTICLE; CALCIUM CELL LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROCORTISONE RELEASE; PRIORITY JOURNAL; STEROIDOGENESIS;

ADRENAL CORTEX; BUCLADESINE; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL LINE; CHOLESTEROL; DEHYDROEPIANDROSTERONE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; HYDROCORTISONE; LYSOPHOSPHOLIPIDS; MAP KINASE SIGNALING SYSTEM; PERTUSSIS TOXIN; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTORS, GABA; RECEPTORS, LDL; SCAVENGER RECEPTORS, CLASS B; SPHINGOSINE; STEROL ESTERASE; TYPE C PHOSPHOLIPASES;

EID: 80755135522     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.08.003     Document Type: Article

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