Rare germline variants in regions of loss of heterozygosity may influence clinical course of hematological malignancies

Leukemia

Volumn 25, Issue 11, 2011, Pages 1782-1784

  Harutyunyan, A ^a   Gisslinger, B ^b   Klampfl, T ^a   Berg, T ^a   Bagienski, K ^a   Gisslinger, H ^b   Kralovics, R ^a,b  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; ERYTHROPOIETIN; GENOMIC DNA; JANUS KINASE 2; TRANSCRIPTION FACTOR EZH2;

ACUTE GRANULOCYTIC LEUKEMIA; ALLELE; BLOOD; BLOOD TRANSFUSION; CHEEK MUCOSA; CHROMOSOME 14Q; CHROMOSOME 9P; CHROMOSOME ARM; DAUGHTER CELL; EXOME; EXON; FANCONI ANEMIA; GENE SEQUENCE; GRANULOCYTE; HEMATOCRIT; HETEROZYGOSITY; HUMAN; HUMAN GENOME PROJECT; KARYOTYPING; LETTER; LEUKOCYTE COUNT; LEUKOCYTOSIS; NONSENSE MUTATION; PEDIGREE ANALYSIS; PHENOTYPE; PHLEBOTOMY; POLYCYTHEMIA VERA; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; TELOMERE; THROMBOCYTOSIS; UNIPARENTAL DISOMY;

GERM-LINE MUTATION; HEMATOLOGIC NEOPLASMS; HUMANS; LOSS OF HETEROZYGOSITY;

EID: 80755132100     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.150     Document Type: Letter

References (6)

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3. Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S et al. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature 2009; 460: 904-908.
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6. Klampfl T, Harutyunyan A, Berg T, Gisslinger B, Schalling M, Bagienski K et al. Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression. Blood 2011; e-pub ahead of print 29 April 2011; doi:10.1182/blood-2011-01-331678.