Precursor lesions of endometrial carcinoma: Diagnostic approach and molecular pathology;Vorläuferläsionen des Endometriumkarzinoms: Diagnostik und Molekularpathologie

Pathologe

Volumn 32, Issue SUPPL.2, 2011, Pages 255-264

  Lax, S ^a  

^a UNIVERSITY HOSPITAL GRAZ   (Austria)

Author keywords

Atypical endometrial hyperplasia; Endometrial neoplasms; Gene expression; Immunohistochemistry; PTEN protein

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN;

ADENOCARCINOMA; ARTICLE; CANCER GRADING; CARCINOMA IN SITU; CELL TRANSFORMATION; ENDOMETRIOID CARCINOMA; ENDOMETRIUM; ENDOMETRIUM HYPERPLASIA; ENDOMETRIUM TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; PATHOLOGY; PRECANCER;

ADENOCARCINOMA, CLEAR CELL; CARCINOMA IN SITU; CARCINOMA, ENDOMETRIOID; CELL TRANSFORMATION, NEOPLASTIC; DNA MISMATCH REPAIR; ENDOMETRIAL HYPERPLASIA; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; NEOPLASM GRADING; PRECANCEROUS CONDITIONS; PTEN PHOSPHOHYDROLASE;

EID: 80755130429     PISSN: 01728113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00292-011-1514-3     Document Type: Article

References (39)

1. Ambros RA (2000) Simple hyperplasia of the endometrium: an evaluation of proliferative activity by Ki-67 immunostaining. Int J Gynecol Pathol 19:206-211 (Pubitemid 30452444)
2. Ambros RA, Sherman ME, Zahn CM, et al. (1995) Endometrial intraepithelial carcinoma: a distinctive lesion specifically associated with tumors displaying serous differentiation. Hum Pathol 26:1260-1267
3. Baak JP, Mutter GL, Robboy S, et al. (2005) The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification system. Cancer 103:2304-2312 (Pubitemid 40686575)
4. Baak JP, Orbo A, Van Diest PJ, et al. (2001) Prospective multicenter evaluation of the morphometric D-score for prediction of the outcome of endometrial hyperplasias. Am J Surg Pathol 25:930-935 (Pubitemid 32594987)
5. Baak JP, Van Diermen B, Steinbakk A, et al. (2005) Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression. Hum Pathol 36:555-561 (Pubitemid 40776009)
6. Bergeron C, Nogales FF, Masseroli M, et al. (1999) A multicentric European study testing the reproducibility of the WHO classification of endometrial hyperplasia with a proposal of a simplified working classification for biopsy and curettage specimens. Am J Surg Pathol 23:1102-1108 (Pubitemid 29409773)
7. Chiesa-Vottero AG, Malpica A, Deavers MT, et al. (2007) Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma. Int J Gynecol Pathol 26:328-333 (Pubitemid 46986071)
8. Dallenbach-Hellweg G (1987) Histopathology of the endometrium. Springer, Berlin Heidelberg New York
9. Ellenson LH, Ronnett BM, Kurman RJ (2011) Precursor lesion of endometrial carcinoma. In: Kurman RJ, Ellenson LH, Ronnett BM (Hrsg) Blaustein's pathology of the female genital tract. Springer, Berlin Heidelberg New York Tokio, S 360-391
10. Hecht JL, Ince TA, Baak JP, et al. (2005) Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosis. Mod Pathol 18:324-330 (Pubitemid 40395349)
11. Jarboe EA, Pizer ES, Miron A, et al. (2009) Evidence for a latent precursor (p53 signature) that may precede serous endometrial intraepithelial carcinoma. Mod Pathol 22:345-350
12. Kendall BS, Ronnett BM, Isacson C, et al. (1998) Reproducibility of the diagnosis of endometrial hyperplasia, atypical hyperplasia, and well-differentiated carcinoma. Am J Surg Pathol 22:1012-1019 (Pubitemid 28364502)
13. Kurman RJ, Kaminski PF, Norris HJ (1985) The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients. Cancer 56:403-412 (Pubitemid 15031667)
14. Lacey JV Jr, Mutter GL, Nucci MR, et al. (2008) Risk of subsequent endometrial carcinoma associated with endometrial intraepithelial neoplasia classification of endometrial biopsies. Cancer 113:2073-2081
15. Lax SF (2007) Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium. Pathology 39:46-54
16. Lax SF (2004) Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. Virchows Arch 444:213-223 (Pubitemid 38446432)
17. Lax SF, Pizer ES, Ronnett BM, et al. (1998) Clear cell carcinoma of the endometrium is characterized by a distinctive profile of p53, Ki-67, estrogen, and progesterone receptor expression. Hum Pathol 29:551-558 (Pubitemid 28272707)
18. Matias-Guiu X, Catasus L, Bussaglia E, et al. (2001) Molecular pathology of endometrial hyperplasia and carcinoma. Hum Pathol 32:569-577 (Pubitemid 32601237)
19. Monte NM, Webster KA, Neuberg D, et al. (2010) Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer. Cancer Res 70:6225-6232
20. Mutter GL (2000) Endometrial intraepithelial neoplasia (EIN): will it bring order to chaos? The Endometrial Collaborative Group. Gynecol Oncol 76:287-290 (Pubitemid 30131494)
21. Mutter GL (2000) Histopathology of genetically defined endometrial precancers. Int J Gynecol Pathol 19:301-309
22. Mutter GL, Baak JP, Crum CP, et al. (2000) Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry. J Pathol 190:462-469 (Pubitemid 30163587)
23. Park H, Seok JM, Yoon BS, et al. (2011) Effectiveness of high-dose progestin and long-term outcomes in young women with early-stage, well-differentiated endometrioid adenocarcinoma of uterine endometrium. Arch Gynecol Obstet.; doi 10.1007/s00404-011-1959-x
24. Randall TC, Kurman RJ (1997) Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40. Obstet Gynecol 90:434-440 (Pubitemid 27357938)
25. Reed SD, Voigt LF, Newton KM, et al. (2009) Progestin therapy of complex endometrial hyperplasia with and without atypia. Obstet Gynecol 113:655-662
26. Santin AD, Bellone S, Van Stedum S, et al. (2005) Determination of HER2/neu status in uterine serous papillary carcinoma: comparative analysis of immunohistochemistry and fluorescence in situ hybridization. Gynecol Oncol 98:24-30 (Pubitemid 40826414)
27. Sherman ME, Ronnett BM, Ioffe OB, et al. (2008) Reproducibility of biopsy diagnoses of endometrial hyperplasia: evidence supporting a simplified classification. Int J Gynecol Pathol 27:318-325
28. Sherman ME, Sturgeon S, Brinton LA, et al. (1997) Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas. Mod Pathol 10:963-968 (Pubitemid 27471115)
29. Tashiro H, Isacson C, Levine R, et al. (1997) p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis. Am J Pathol 150:177-185 (Pubitemid 27027108)
30. Tavassoli FA, Devilee P (Hrsg) (2003) Tumours of the breast and female genital organs. IARC, Lyon
31. Trimble CL, Kauderer J, Zaino R, et al. (2006) Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer 106:812-819 (Pubitemid 43238448)
32. Wheeler DT, Bell KA, Kurman RJ, et al. (2000) Minimal uterine serous carcinoma: diagnosis and clinicopathologic correlation. Am J Surg Pathol 24:797-806 (Pubitemid 30366266)
33. Wheeler DT, Bristow RE, Kurman RJ (2007) Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins. Am J Surg Pathol 31:988-998 (Pubitemid 47012294)
34. Yemelyanova A, Ji H, Shih Ie M, et al. (2009) Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases. Am J Surg Pathol 33:1504-1514
35. Yin Y, Shen WH (2008) PTEN: a new guardian of the genome. Oncogene 27:5443-5453
36. Zaino RJ, Kauderer J, Trimble CL, et al. (2006) Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer 106:804-811 (Pubitemid 43238447)
37. Zheng W, Liang SX, Yu H, et al. (2004) Endometrial glandular dysplasia: a newly defined precursor lesion of uterine papillary serous carcinoma. Part I: morphologic features. Int J Surg Pathol 12:207-223 (Pubitemid 39063348)
38. Zheng W, Xiang L, Fadare O, et al. (2011) A proposed model for endometrial serous carcinogenesis. Am J Surg Pathol 35:e1-e14
39. Zielonke N, Hackl M, Baldaszti E (2010) Krebsinzidenz und Krebsmortalität in Österreich. Statistik Austria, Wien