Treatment with recombinant equine follicle stimulating hormone (reFSH) followed by recombinant equine luteinizing hormone (reLH) increases embryo recovery in superovulated mares

Animal Reproduction Science

Volumn 128, Issue 1-4, 2011, Pages 52-59

  Meyers Brown, G ^a   Bidstrup, L A ^a   Famula, T R ^a   Colgin, M ^b   Roser, J F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b AspenBio Pharma   (United States)

Author keywords

Anovulatory follicles; Embryo recovery; Hormones; Mares; Recombinant equine FSH and LH; Superovulation

Indexed keywords

FOLLITROPIN; LUTEINIZING HORMONE; RECOMBINANT PROTEIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; EMBRYO TRANSFER; FEMALE; HORSE; OVARY FOLLICLE; PHYSIOLOGY; PRENATAL DEVELOPMENT; RANDOMIZED CONTROLLED TRIAL; TIME;

ANIMALS; EMBRYO TRANSFER; FEMALE; FOLLICLE STIMULATING HORMONE; HORSES; LUTEINIZING HORMONE; OVARIAN FOLLICLE; RECOMBINANT PROTEINS; TIME FACTORS;

EQUIDAE;

EID: 80655148902     PISSN: 03784320     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anireprosci.2011.09.002     Document Type: Article

References (46)

1. Accardo C., Dattena M., Pilichi S., Mara L., Chessa B., Cappai P. Effect of recombinant human FSH and LH on in vitro maturation of sheep oocytes; embryo development and viability. Anim. Reprod. Sci. 2004, 81:77-86.
2. Alvarenga M.A., McCue P.M., Bruemmer J., Neves Neto J.R., Squire E.L. Ovarian superstimulatory response and embryo production in mares treated with equine pituitary extract twice daily. Theriogenology 2001, 56:879-887.
3. Araujo G.H., Rocha Filho A.N., Lopes E.P., Moya C.F., Alvarenga M.A. Use of a low dose of equine purified FSH to induce multiple ovulations in mares. Reprod. Domest. Anim. 2009, 44:380-383.
4. Becker S.E., Johnson A.L. Effects of gonadotropin-releasing hormone infused in a pulsatile or continuous fashion on serum gonadotropin concentrations and ovulation in the mare. J. Anim. Sci. 1992, 70:1208-1215.
5. Bezard J., Mekarska A., Goudet G., Duchamp G., Palmer E. Timing of in vivo maturation of equine preovulatory oocytes and competence for in vitro maturation of immature oocytes collected simultaneously. Equine Vet. J. Suppl. 1997, 33-37.
6. Bing Y.Z., Naga T., Rodriguez-Martinez H. Effects of cysteamine, FSH and estradiol-17beta on in vitro maturation of porcine oocytes. Theriogenology 2001, 55:867-876.
7. Blanco I.D.P., Devito L.G., Ferreira H.N., Araujo G.H.M., Fernandes C.B., Alvarenga M.A., Landim-Alvarenga F.C. Collection rates and morphology of equine oocytes obtained from immature follicles after treatment with equine pituitary extract (EPE) and human chorionic gonadotropin. J. Equine Vet. Sci. 2009, 29:613-617.
8. Briant C., Toutain P.L., Ottogalli M., Magallon T., Guillaume D. Kinetic studies and production rate of equine (e) FSH in ovariectomized pony mares. Application to the determination of a dosage regimen for eFSH in a superovulation treatment. J. Endocrinol. 2004, 182:43-54.
9. Carmo M.T., Losinno L., Aquilar J.J., Araujo G.H.M., Alveranga M.A. Oocyte transport to the oviduct of superovulated mares. Anim. Reprod. Sci. 2006, 94:337-339.
10. Carnevale E.M., Bozzola J.J, King S.S., Schmitt S.J., Gates H.D. Comparison of oocytes from young and old mares with light and electron microscopy. Theriogenolgy 1999, 29:9.
11. Carnevale E.M., Ginther O.J. Defective oocytes as a cause of subfertility in old mares. Biol. Reprod. Monogr. 1995, 209-214.
12. Fatum M., Gyo Y., Diana P., Laufer N., Simon A. Is estradiol mandatory for an adequate follicular and embryo development? A mouse model using aromatase inhibitor (anastrozole). J. Assist. Reprod. Genet. 2006, 23:407-412.
13. Geary R.T., Weber J.A., Woods G.L. Hastened transport of equine embryos through the oviduct of the mare. Theriogenology 1989, 31:973-978.
14. Ginther O.J., Beg M.A., Donadeu F.X., Bergfelt D.R. Mechanism of follicle deviation in monovular farm species. Anim. Reprod. Sci. 2003, 78:239-257.
15. Ginther O.J., Beg M.A., Gastal E.L., Gastal M.O., Baerwald A.R., Pierson R.A. Systemic concentrations of hormones during the development of follicular waves in mares and women: a comparative study. Reproduction 2005, 130:379-388.
16. Ginther O.J., Gastal E.L., Gastal M.O., Beg M.A. Regulation of circulating gonadotropins by the negative effects of ovarian hormones in mares. Biol. Reprod. 2005, 73:315-323.
17. Goudet G., Belin F., Bezard J., Gerard N. Intrafollicular content of luteinizing hormone receptor, alpha-inhibin, and aromatase in relation to follicular growth, estrous cycle stage, and oocyte competence for in vitro maturation in the mare. Biol. Reprod. 1999, 60:1120-1127.
18. Hillier S.G. Gonadotropic control of ovarian follicular growth and development. Mol. Cell. Endocrinol. 2001, 179:39-46.
19. Hillier S.G. Paracrine support of ovarian stimulation. Mol. Hum. Reprod. 2009, 15:843-850.
20. Hinrichs K., Schmidt A.L. Meiotic competence in horse oocytes: interactions among chromatin configuration, follicle size, cumulus morphology, and season. Biol. Reprod. 2000, 62:1402-1408.
21. Jablonka-Shariff A., Roser J.F., Bousfield G.R., Wolfe M.W., Sibley L.E., Colgin M., Boime I. Expression and bioactivity of a single chain recombinant equine luteinizing hormone (reLH). Theriogenology 2007, 67:311-320.
22. Jennings M.W., Boime I., Daphna-Iken D., Jablonka-Shariff A., Conley A.J., Colgin M., Bidstrup L.A., Meyers-Brown G.A., Famula T.R., Roser J.F. The efficacy of recombinant equine follicle stimulating hormone (reFSH) to promote follicular growth in mares using a follicular suppression model. Anim. Reprod. Sci. 2009, 116:291-307.
23. Kawashima I., Okazaki T., Noma N., Nishibori M., Yamashita Y., Shimada M. Sequential exposure of porcine cumulus cells to FSH and/or LH is critical for appropriate expression of steroidogenic and ovulation-related genes that impact oocyte maturation in vivo and in vitro. Reproduction 2008, 136:9-21.
24. Lindbloom S.M., Farmerie T.A., Clay C.M., Seidel G.E., Carnevale E.M. Potential involvement of EGF-like growth factors and phosphodiesterases in initiation of equine oocyte maturation. Anim. Reprod. Sci. 2008, 103:187-192.
25. Logan N.L., McCue P.M., Alonso M.A., Squires E.L. Evaluation of three equine FSH superovulation protocols in mares. Anim. Reprod. Sci. 2007, 102:48-55.
26. Machado M.S., Carmo M.T., Squires E.L., Roser J.F., Alvarenga M.A. Follicular dynamic, superovulatory response and embryo recovery rates in mares treated with constant and decreasing doses of equine pituitary extract (EPE) and purified equine FSH. Havemeyer Found. Monogr. Ser. 2005, 14:75-76.
27. Machado M.S., Roser J.F., Greco G.M., Araujo G.H., Alvarenga M.A. Effect of superovulatory treatment with equine pituitary extract and equine FSH on endocrine profiles in mares. 7th International Symposium on Equine Embryo Transfer 2008, 59-60. Magdalene College, Cambridge, England. W.R. Allen (Ed.).
28. Matteri R.L., Roser J.F., Baldwin D.M., Lipovetsky V., Papkoff H. Characterization of a monoclonal antibody which detects luteinizing hormone from diverse mammalian species. Domest. Anim. Endocrinol. 1987, 4:157-165.
29. McCue P.M., Patten M., Denniston D., Bruemmer J.E., Squires E.L. Strategies for using eFSH for superovulating mares. J. Equine Vet. Sci. 2008, 28:91-96.
30. McKinnon A.O., Squires E.L. Morphologic assessment of the equine embryo. J. Am. Vet. Med. Assoc. 1988, 192:401-406.
31. Meyers-Brown G.A., McCue P.M., Niswender K.D., Squires E.L., DeLuca C.A., Bidstrup L.A., Colgin M., Famula T.R., Roser J.F. Superovulation in mares using recombinant equine follicle stimulating hormone (reFSH): ovulation rates, embryo retrieval and hormone profiles. J. Equine Vet. Sci. 2010, 30:560-568.
32. Mihm M., Baker P.J., Ireland J.L., Smith G.W., Coussens P.M., Evans A.C., Ireland J.J. Molecular evidence that growth of dominant follicles involves a reduction in follicle-stimulating hormone dependence and an increase in luteinizing hormone dependence in cattle. Biol. Reprod. 2006, 74:1051-1059.
33. Nagy P., Huszenicza G., Reiczigel J., Juhasz J., Kulcsar M., Abavary K., Guillaume D. Factors affecting plasma progesterone concentration and the retrospective determination of time of ovulation in cyclic mares. Theriogenology 2004, 61:203-214.
34. Prochazka R., Nemcova L., Nagyova E., Scsukova S., Mlynarcikova A. Development of functional LH Receptors on pig cumulus-oocyte complexes cultured in vitro by a novel two-step culture system. Mol. Reprod. Dev. 2009, 76:751-761.
35. Raz T., Gray A., Hunter B., Card C. Early effects of equine FSH (eFSH) treatment on hormonal and reproductive parameters in mares intended to carry their own pregnancy. Anim. Reprod. Sci. 2009, 115:76-87.
36. Rosas C.A., Alberio R.H., Baranao J.L., Aguero A., Chaves M.G. Evaluation of two treatments in superovulation of mares. Theriogenology 1998, 49:1257-1264.
37. Rosen M.P., Zamah A.M., Shen S., Dobson A.T., McCulloch C.E., Rinaudo P.F., Lamb J.D., Cedars M.I. The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery. Reprod. Biol. Endocrinol. 2009, 7:35.
38. Scoggin C.F., Meira C., McCue P.M., Carnevale E.M., Nett T.M., Squires E.L. Strategies to improve the ovarian response to equine pituitary extract in cyclic mares. Theriogenology 2002, 58:151-164.
39. Silva C.C., Groome N.P., Knight P.G. Demonstration of a suppressive effect of inhibin alpha-subunit on the developmental competence of in vitro matured bovine oocytes. J. Reprod. Fertil. 1999, 115:381-388.
40. Silvestre M.A., Alfonso J., Garcia-Mengual E., Salvador I., Duque C.C., Molina I. Effect of recombinant human follicle-stimulating hormone and luteinizing hormone on in vitro maturation of porcine oocytes evaluated by the subsequent in vitro development of embryos obtained by in vitro fertilization, intracytoplasmic sperm injection, or parthenogenetic activation. J. Anim. Sci. 2007, 85:1156-1160.
41. Squires E.L. Superovulation in mares. Vet. Clin. North Am. Equine Pract. 2006, 22:819-830.
42. Takagi M., Kim I.H., Izadyar F., Hyttel P., Bevers M.M., Dieleman S.J., Hendriksen P.J., Vos P.L. Impaired final follicular maturation in heifers after superovulation with recombinant human FSH. Reproduction 2001, 121:941-951.
43. Webb R., Garnsworthy P.C., Gong J.G., Armstrong D.G. Control of follicular growth: local interactions and nutritional influences. J. Anim. Sci. 2004, 82(E-Suppl.):E63-E74.
44. Welch S.A., Denniston D.J., Hudson J.J., Bruemmer J.E., McCue P.M., Squires E.L. Exogenous eFSH, follicle coasting, and hCG as a novel superovulation regimen in mares. J. Equine Vet. Sci. 2006, 26:262-270.
45. Woods G. Pregnancy loss: a major cause of subfertility in the mare. Equine Pract. 1989, 29-32.
46. Yoon M.J., Boime I., Colgin M., Niswender K.D., King S.S., Alvarenga M., Jablonka-Shariff A., Pearl C.A., Roser J.F. The efficacy of a single chain recombinant equine luteinizing hormone (reLH) in mares: induction of ovulation, hormone profiles, and inter-ovulatory intervals. Domest. Anim. Endocrinol. 2007, 33:470-479.