In vivo photoacoustic imaging of chemotherapy-induced apoptosis in squamous cell carcinoma using a near-infrared caspase-9 probe

Journal of Biomedical Optics

Volumn 16, Issue 11, 2011, Pages

  Yang, Qiuhong ^a   Cui, Huizhong ^b   Cai, Shuang ^a   Yang, Xinmai ^b   Forrest, M Laird ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b University of Kansas   (United States)

Author keywords

apoptosis; cancer imaging; caspase; in vivo; photoacoustic imaging

Indexed keywords

ANTICANCER DRUG; APOPTOTIC; APOPTOTIC RESPONSE; CANCER CELLS; CANCER IMAGING; CASPASE-3; CASPASES; CHEMOTHERAPY TREATMENT; CIS-PLATIN; CONTRAST AGENT; CONTRAST ENHANCEMENT; HEAD-AND-NECK TUMOR; HIGH SPECIFICITY; IMAGING PROBE; IN VIVO; MORPHOLOGICAL CHANGES; MOUSE TUMORS; NEAR INFRARED; NUDE MICE; PHARMACOLOGICAL EFFECTS; PHOTO-ACOUSTIC IMAGING; PROGRAMMED CELL DEATHS; REAL TIME; SQUAMOUS CELL CARCINOMA; TAIL VEINS; UNTREATED CONTROL;

CHEMOTHERAPY; DISEASES; INFRARED DEVICES; MAMMALS; MEDICAL IMAGING; MICROSCOPIC EXAMINATION; PHOTOACOUSTIC EFFECT; PLATINUM COMPOUNDS; PROBES; TUMORS;

CELL DEATH;

MUS MUSCULUS;

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CISPLATIN; FLUORESCENT DYE;

ANIMAL; APOPTOSIS; ARTICLE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; FEMALE; HEAD AND NECK TUMOR; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NUDE MOUSE; PATHOLOGY; PHOTOACOUSTICS; SQUAMOUS CELL CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CASPASE 9; CISPLATIN; FEMALE; FLUORESCENT DYES; HEAD AND NECK NEOPLASMS; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; MOLECULAR IMAGING; MOLECULAR PROBES; PHOTOACOUSTIC TECHNIQUES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80655146015     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3650240     Document Type: Article

References (7)

1. K. H. Song and L. V. Wang, Deep reflection-mode photoacoustic imaging of biological tissue., J. Biomed. Opt. 12 (6), 060503 (2007). 10.1117/1.2818045
2. H. Cui, J. Staley, and X. Yang, Integration of photoacoustic imaging and high-intensity focused ultrasound., J. Biomed. Opt. 15 (2), 021312 (2010). 10.1117/1.3365948
3. J. Staley, P. Grogan, A. K. Samadi, H. Cui, M. S. Cohen, and X. Yang, Growth of melanoma brain tumors monitored by photoacoustic microscopy., J. Biomed. Opt. 15 (4), 040510 (2010). 10.1117/1.3478309
4. D. McCormack, M. Al-Shaer, B. S. Goldschmidt, P. S. Dale, C. Henry, C. Papageorgio, K. Bhattacharyya, and J. A. Viator, Photoacoustic detection of melanoma micrometastasis in sentinel lymph nodes., J. Biomech. Eng. 131 (7), 074519 (2009). 10.1115/1.3169247
5. R. Sadhukhan, J. W. Leone, J. Lull, Z. Wang, R. F. Kletzien, R. L. Heinrikson, and A. G. Tomasselli, An efficient method to express and refold a truncated human procaspase-9: a caspase with activity toward Glu-X bonds., Protein Expression Purif. 46 (2), 299-308 (2006). 10.1016/j.pep.2005.09.006
6. Y. Lu, Q. Yang, Y. Xie, S. Duan, S. Cai, and M. L. Forrest, A sensitive near-infrared fluorescent probe for caspase-mediated apoptosis: synthesis and application in cell imaging., Drug Discov. Ther. (in press).
7. U. Haberkorn, R. Kinscherf, P. H. Krammer, W. Mier, and M. Eisenhut, Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone., Nucl. Med. Biol. 28 (7), 793-798 (2001). 10.1016/S0969-8051(01)00247-5 (Pubitemid 32900637)