MGBG in combined anticancer chemotherapy

Letters in Drug Design and Discovery

Volumn 8, Issue 10, 2011, Pages 897-903

  Goncalves R F ^a   Kriechammer, G ^a   Marques, M P M ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Anticancer; Breast cancer; Carboplatin; Cisplatin; MGBG

Indexed keywords

CARBOPLATIN; CISPLATIN; MITOGUAZONE; POLYAMINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW SUPPRESSION; BREAST CANCER; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CELL GROWTH; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DNA DAMAGE; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG POTENTIATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; MUCOSA INFLAMMATION; PRIORITY JOURNAL;

EID: 80655143441     PISSN: 15701808     EISSN: 1875628X     Source Type: Journal    
DOI: 10.2174/157018011797655197     Document Type: Article

References (31)

1. Williams-Ashman, H. G.; Schenone, A., Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases. Biochem Biophys Res Commun 1972, 46(1), 288-95.
2. Ferioli, M. E.; Berselli, D.; Caimi, S., Effect of mitoguazone on polyamine oxidase activity in rat liver. Toxicol Appl Pharmacol 2004, 201(2), 105-11. (Pubitemid 39487158)
3. Seppanen, P.; Fagerstrom, R.; Alhonen-Hongisto, L.; Elo, H.; Lumme, P.; Janne, J., Glyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in tumour cells. Biochem J 1984, 221(2), 483-8. (Pubitemid 14052344)
4. Von Hoff, D. D., MGBG: teaching an old drug new tricks. Ann Oncol 1994, 5(6), 487-93. (Pubitemid 24223500)
5. Ishmael, D. R.; Chen, W. R.; Nordquist, J. A.; Liu, H.; Nordquist, R. E., Synergistic effect of sequential administration of mitoguazone (MGBG) and gemcitabine in treating tissue cultured human breast cancer cells and mammary rat tumors. Cancer Invest 2003, 21(2), 217-26. (Pubitemid 36532168)
6. Wallace, H. M.; Fraser, A. V., Inhibitors of polyamine metabolism: review article. Amino Acids 2004, 26(4), 353-65. (Pubitemid 39093138)
7. Nishioka, K., International Symposium on Polyamines in Cancer. Critical role of polyamines in cancer: basic mechanisms and clinical approaches. Cancer Res 1993, 53(11), 2689-92. (Pubitemid 23168041)
8. Freireich, E. J.; Frei, E., 3rd; Karon, M., Methylglyoxal bis (guanylhydrazone): a new agent active against acute myelocytic leukemia. Cancer Chemother Rep 1962, 16, 183-6.
9. Gastaut, J. A.; Tell, G.; Schechter, P. J.; Maraninchi, D.; Mascret, B.; Carcassonne, Y., Treatment of acute myeloid leukemia and blastic phase of chronic myeloid leukemia with combined eflornithine (alpha difluoromethylornithine) and methylglyoxal-bis-guanyl hydrazone (methyl-GAG). Cancer Chemother Pharmacol 1987, 20(4), 344-8. (Pubitemid 18007436)
10. Regelson, W.; Holland, J. F., Initial clinical study of parenteral methylglyoxal bis(guanylhydrazone) diacetate. Cancer Chemother Rep 1961, 11, 81-6.
11. Dabich, L.; Liepman, M. K., Cisplatin, VP-16-213 and MGBG (methylglyoxal bis guanylhydrazone) combination chemotherapy in refractory lymphoma, a phase II study. Invest New Drugs 1988, 6(3), 231-7.
12. Coughlin, S. S.; Ekwueme, D. U., Breast cancer as a global health concern. Cancer Epidemiology 2009, 33(5), 315-318.
13. Martin, A. R.; Carides, A. D.; Pearson, J. D.; Horgan, K.; Elmer, M.; Schmidt, C.; Cai, B.; Chawla, S. P.; Grunberg, S. M., Functional relevance of antiemetic control: experience using the FLIE questionnaire in a randomised study of the NK-1 antagonist aprepitant. European Journal of Cancer 2003, 39(10), 1395-1401. (Pubitemid 36773782)
14. Schnell, F. M., Chemotherapy-induced nausea and vomiting: the importance of acute antiemetic control. Oncologist 2003, 8(2), 187-98. (Pubitemid 36428284)
15. Yde, C. W.; Issinger, O. G., Enhancing cisplatin sensitivity in MCF-7 human breast cancer cells by down-regulation of Bcl-2 and cyclin D1. Int J Oncol 2006, 29(6), 1397-404.
16. Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; Mc Mahon, J.; Vistica, D.; Warren, J. T.; Bokesch, H.; Kenney, S.; Boyd, M. R., New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990, 82(13), 1107-12. (Pubitemid 20213250)
17. Papazisis, K. T.; Geromichalos, G. D.; Dimitriadis, K. A.; Kortsaris, A. H., Optimization of the sulforhodamine B colorimetric assay. J Immunol Methods 1997, 208(2), 151-8. (Pubitemid 28015342)
18. Hamid, R.; Rotshteyn, Y.; Rabadi, L.; Parikh, R.; Bullock, P., Comparison of alamar blue and MTT assays for high through-put screening. Toxicol In Vitro 2004, 18(5), 703-10. (Pubitemid 38900879)
19. Scudiero, D. A.; Shoemaker, R. H.; Paull, K. D.; Monks, A.; Tierney, S.; Nofziger, T. H.; Currens, M. J.; Seniff, D.; Boyd, M. R., Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 1988, 48(17), 4827-33.
20. Marques, M. P.; Gil, F. P.; Calheiros, R.; Battaglia, V.; Brunati, A. M.; Agostinelli, E.; Toninello, A., Biological activity of antitumoural MGBG: the structural variable. Amino Acids 2008, 34(4), 555-64.
21. Ekelund, S.; Sjoholm, A.; Nygren, P.; Binderup, L.; Larsson, R., Cellular pharmacodynamics of the cytotoxic guanidino-containing drug CHS 828. Comparison with methylglyoxal-bis(guanylhydrazone). Eur J Pharmacol 2001, 418(1-2), 39-45. (Pubitemid 32378808)
22. Agostinelli, E.; Arancia, G.; Vedova, L. D.; Belli, F.; Marra, M.; Salvi, M.; Toninello, A., The biological functions of polyamine oxidation products by amine oxidases: perspectives of clinical applications. Amino Acids 2004, 27(3-4), 347-58. (Pubitemid 40110080)
23. Agostinelli, E.; Marques, M. P.; Calheiros, R.; Gil, F. P.; Tempera, G.; Viceconte, N.; Battaglia, V.; Grancara, S.; Toninello, A., Polyamines: fundamental characters in chemistry and biology. Amino Acids 2010, 38(2), 393-403.
24. Kim, J. S.; Lee, J.; Chung, H. W.; Choi, H.; Paik, S. G.; Kim, I. G., Methylglyoxal-bis(guanylhydrazone), a polyamine analogue, sensitized [gamma]-radiation-induced cell death in HL-60 leukemia cells: Sensitizing effect of MGBG on [gamma]-radiation-induced cell death. Environmental Toxicology and Pharmacology 2006, 22(2), 160-166. (Pubitemid 44081886)
25. Cepeda, V.; Fuertes, M. A.; Castilla, J.; Alonso, C.; Quevedo, C.; Perez, J. M., Biochemical mechanisms of cisplatin cytotoxicity. Anticancer Agents Med Chem 2007, 7(1), 3-18. (Pubitemid 46062402)
26. Kartalou, M.; Essigmann, J. M., Mechanisms of resistance to cisplatin. Mutat Res 2001, 478(1-2), 23-43. (Pubitemid 32530848)
27. Aung, H.; Mehendale, S.; Wang, C.; Xie, J.-T.; Mc Entee, E.; Yuan, C.-S., Cisplatin's tumoricidal effect on human breast carcinoma MCF-7 cells was not attenuated by American ginseng. Cancer Chemotherapy and Pharmacology 2007, 59(3), 369-374. (Pubitemid 46025524)
28. Gonçalves, R. Evaluation of Antitumor Activity of MGBG in Breast Cancer Cells. University of Coimbra, Coimbra, 2010.
29. Hah, S. S.; Stivers, K. M.; de Vere White, R. W.; Henderson, P. T., Kinetics of carboplatin-DNA binding in genomic DNA and bladder cancer cells as determined by accelerator mass spectrometry. Chem Res Toxicol 2006, 19(5), 622-6. (Pubitemid 43800978)
30. Kozelka, J., Molecular origin of the sequence-dependent kinetics of reactions between cisplatin derivatives and DNA. Inorganica Chimica Acta 2009, 362(3), 651-668.
31. Seppanen, P.; Alhonen-Hongisto, L.; Poso, H.; Janne, J., Sensitive enzymic determination of methylglyoxal bis(guanylhydrazone) in cultured cells and in animal tissues. FEBS Lett 1980, 111(1), 99-103. (Pubitemid 10103777)