Intensity of cytosol expression of 8-OHdG in normal renal tubules is associated with the severity of renal fibrosis

Swiss Medical Weekly

Volumn 141, Issue OCTOBER, 2011, Pages

  Tsai, Jen Pi ^a,b   Liou, Jia Hung ^a,c   Yeh, Kun Tu ^a,c   Tai, Hui Chun ^c   Cheng, Ya Wen ^a   Chang, Horng Rong ^a,d  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

8 hydroxy 2 deoxyguanosine; Chronic kidney disease; Immunohistochemical stain; Reactive oxygen species; Renal fibrosis

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; CREATININE; REACTIVE OXYGEN METABOLITE; 8-HYDROXY-2'-DEOXYGUANOSINE; DEOXYGUANOSINE; DRUG DERIVATIVE;

ADULT; AGED; ARTICLE; CELL NUCLEUS; CHRONIC KIDNEY DISEASE; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; CYTOSOL; DISEASE SEVERITY; FEMALE; GLOMERULUS; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CELL; KIDNEY FIBROSIS; KIDNEY INTERSTITIUM; KIDNEY PARENCHYMA; KIDNEY TUBULE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; TRANSITIONAL CELL CARCINOMA; UNIVARIATE ANALYSIS; CHRONIC KIDNEY FAILURE; FIBROSIS; HOSPITALIZATION; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY;

ADULT; AGED; BIOLOGICAL MARKERS; CYTOSOL; DEOXYGUANOSINE; FEMALE; FIBROSIS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY FAILURE, CHRONIC; KIDNEY TUBULES; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX;

EID: 80655137769     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: 10.4414/smw.2011.13268     Document Type: Article

References (25)

1. Knight JA. Diseases related to oxygen-derived free radicals. Ann Clin Lab Sci. 1995;25(2):111-21.
2. Ha H, Lee HB. Reactive oxygen species and matrix remodeling in diabetic kidney. J Am Soc Nephrol. 2003;14(8 Suppl 3):S246-249. (Pubitemid 36903934)
3. Okamura DM, Himmelfarb J. Tipping the redox balance of oxidative stress in fibrogenic pathways in chronic kidney disease. Pediatr Nephrol. 2009;24(12):2309-19.
4. Measurement of DNA oxidation in human cells by chromatographic and enzymic methods. Free Radic Biol Med. 2003;34(8):1089-99.
5. Domenici FA, Vannucchi MT, Jordao AA, Jr., Meirelles MS, Vannucchi H. DNA oxidative damage in patients with dialysis treatment. Ren Fail. 2005;27(6):689-94. (Pubitemid 41748120)
6. Dincer Y, Sekercioglu N, Pekpak M, Gunes KN, Akcay T. Assessment of DNA oxidation and antioxidant activity in hypertensive patients with chronic kidney disease. Ren Fail. 2008;30(10):1006-11.
7. Remuzzi G, Bertani T. Pathophysiology of progressive nephropathies. N Engl J Med. 1998;339(20):1448-56. (Pubitemid 28516069)
8. Yamagishi S, Inagaki Y, Okamoto T, Amano S, Koga K, Takeuchi M. Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells. Kidney Int. 2003;63(2):464-73. (Pubitemid 36126793)
9. Ha H, Lee HB. Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose. Kidney Int Suppl. 2000;77:S19-25.
10. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2 Suppl 1):S1-266.
11. Solez K, Colvin RB, Racusen LC, Sis B, Halloran PF, Birk PE, et al. Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant. 2007;7(3):518-26. (Pubitemid 46376465)
12. Tsai YY, Cheng YW, Lee H, Tsai FJ, Tseng SH, Lin CL, et al. Oxidative DNA damage in pterygium. Mol Vis. 2005;11:71-5. (Pubitemid 41358306)
13. Brenner BM. Remission of renal disease: recounting the challenge, acquiring the goal. J Clin Invest. 2002;110(12):1753-8. (Pubitemid 36076479)
14. Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int. 2006;69(2):213-7. (Pubitemid 43323069)
15. Eberhardt W, Pfeilschifter J. Nitric oxide and vascular remodeling: spotlight on the kidney. Kidney Int Suppl. 2007(106):S9-S16. (Pubitemid 47172556)
16. Huang XB, Ito F, Nakazawa H, Toma H. Increased expression of 8-hydroxydeoxyguanosine in acquired cystic disease of the kidney. Nephron. 1999;81(4):458-9. (Pubitemid 29150140)
17. Cochrane AL, Ricardo SD. Oxidant stress and regulation of chemokines in the development of renal interstitial fibrosis. Contrib Nephrol. 2003;139:102-19.
18. Fujii H, Nishijima F, Goto S, Sugano M, Yamato H, Kitazawa R, et al. Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress. Nephrol Dial Transplant. 2009;24(7):2089-95.
19. Shah SV, Baliga R, Rajapurkar M, Fonseca VA. Oxidants in chronic kidney disease. J Am Soc Nephrol. 2007;18(1):16-28. (Pubitemid 46053418)
20. Jeong KH, Lee TW, Ihm CG, Lee SH, Moon JY, Lim SJ. Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats. Am J Nephrol. 2009;29(3):274-82.
21. Nomoto K, Tsuneyama K, Takahashi H, Murai Y, Takano Y. Cytoplasmic fine granular expression of 8-hydroxydeoxyguanosine reflects early mitochondrial oxidative DNA damage in nonalcoholic fatty liver disease. Appl Immunohistochem Mol Morphol. 2008;16(1):71-5.
22. Chuma M, Hige S, Nakanishi M, Ogawa K, Natsuizaka M, Yamamoto Y, et al. 8-Hydroxy-2′-deoxy-guanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. J Gastroenterol Hepatol. 2008;23(9):1431-6.
23. Akcay T, Saygili, Angican G, Yalcin V. Increased formation of 8-hydroxy-2′-deoxyguanosinein peripheral blood leukocytes in bladder cancer. Urol Int. 2003;71(3):271-4. (Pubitemid 37186742)
24. Miyake H, Hara I, Kamidono S, Eto H. Prognostic significance of oxidative and damage evaluated by 8-hydroxy-2′-deoxyguanosine in patients undergoing radical nephrectomy for renal cell carcinoma. Urology. 2004;64(5):1057-61. (Pubitemid 39469545)
25. Chang CH, Yang CM, Yang AH. Renal diagnosis of chronic hemodialysis patients with urinary tract transitional cell carcinoma in Taiwan. Cancer. 2007;109(8):1487-92. (Pubitemid 46595682)