Development of a liquid chromatography-tandem mass spectrometry assay of six antimicrobials in plasma for pharmacokinetic studies in premature infants

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 30, 2011, Pages 3497-3506

  Cohen Wolkowiez, Michael ^a   White, Nicole R ^b   Bridges, Arlene ^c   Benjamin, Daniel K ^a   Kashuba, Angela D M ^b  

^a DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Antibiotics; Antivirals; HPLC; Mass spectrometry; Neonates; Prematurity

Indexed keywords

ANTIVIRALS; CLINICAL PHARMACOKINETICS; CONCENTRATION RANGES; EXTRACTION PROCEDURE; HIGH THROUGHPUT; HPLC; HUMAN PLASMAS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ASSAYS; LOWER LIMIT OF QUANTIFICATIONS; MEROPENEM; METRONIDAZOLE; NEONATES; PHARMACOKINETIC STUDIES; PIPERACILLIN; PLASMA VOLUME; PREMATURE INFANTS; PREMATURITY; SAMPLE VOLUME; TAZOBACTAM;

DRUG PRODUCTS; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; VIRUSES;

LIQUID CHROMATOGRAPHY;

ACICLOVIR; AMPICILLIN; MEROPENEM; METRONIDAZOLE; PIPERACILLIN; TAZOBACTAM;

ACCURACY; ARTICLE; DRUG BLOOD LEVEL; DRUG STABILITY; HUMAN; INFANT; LIQUID CHROMATOGRAPHY; PREMATURITY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANTI-BACTERIAL AGENTS; ANTIVIRAL AGENTS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 80555131038     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.09.031     Document Type: Article

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