Single bout of running exercise changes LC3-II expression in rat cardiac muscle

Biochemical and Biophysical Research Communications

Volumn 414, Issue 4, 2011, Pages 756-760

  Ogura, Yuji ^a   Iemitsu, Motoyuki ^b   Naito, Hisashi ^c   Kakigi, Ryo ^c   Kakehashi, Chiaki ^a   Maeda, Seiji ^d   Akema, Tatsuo ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b RITSUMEIKAN UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Cardiac work; Endurance exercise; Protein turnover; Proteolysis; Western blotting

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3 II; PROTEIN KINASE B; PROTEIN P62; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; ENZYME PHOSPHORYLATION; EXERCISE; HEART MUSCLE; HEART WORK; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RUNNING; TREADMILL;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; HEAT-SHOCK PROTEINS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MYOCARDIUM; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RUNNING; TOR SERINE-THREONINE KINASES;

MAMMALIA; RATTUS;

EID: 80555130931     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.09.152     Document Type: Article

References (28)

1. Gustafsson A.B., Gottlieb R.A. Eat your heart out: role of autophagy in myocardial ischemia/reperfusion. Autophagy 2008, 4:416-421.
2. Gustafsson A.B., Gottlieb R.A. Recycle or die: the role of autophagy in cardioprotection. J. Mol. Cell. Cardiol. 2008, 44:654-661.
3. Mizushima N., Yamamoto A., Matsui M., Yoshimori T., Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 2004, 15:1101-1111.
4. Kanamori H., Takemura G., Maruyama R., Goto K., Tsujimoto A., Ogino A., Li L., Kawamura I., Takeyama T., Kawaguchi T., Nagashima K., Fujiwara T., Fujiwara H., Seishima M., Minatoguchi S. Functional significance and morphological characterization of starvation-induced autophagy in the adult heart. Am. J. Pathol. 2009, 174:1705-1714.
5. Matsui Y., Takagi H., Qu X., Abdellatif M., Sakoda H., Asano T., Levine B., Sadoshima J. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ. Res. 2007, 100:914-922.
6. Hamacher-Brady A., Brady N.R., Gottlieb R.A. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J. Biol. Chem. 2006, 281:29776-29787.
7. Bahro M., Pfeifer U. Short-term stimulation by propranolol and verapamil of cardiac cellular autophagy. J. Mol. Cell. Cardiol. 1987, 19:1169-1178.
8. Pfeifer U., Fohr J., Wilhelm W., Dammrich J. Short-term inhibition of cardiac cellular autophagy by isoproterenol. J. Mol. Cell. Cardiol. 1987, 19:1179-1184.
9. Gleeson T.T., Baldwin K.M. Cardiovascular response to treadmill exercise in untrained rats. J. Appl. Physiol. 1981, 50:1206-1211.
10. Maeda S., Miyauchi T., Iemitsu M., Tanabe T., Irukayama-Tomobe Y., Goto K., Yamaguchi I., Matsuda M. Involvement of endogenous endothelin-1 in exercise-induced redistribution of tissue blood flow: an endothelin receptor antagonist reduces the redistribution. Circulation 2002, 106:2188-2193.
11. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
12. Bjorkoy G., Lamark T., Pankiv S., Overvatn A., Brech A., Johansen T. Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol. 2009, 452:181-197.
13. Iemitsu M., Maeda S., Jesmin S., Otsuki T., Kasuya Y., Miyauchi T. Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise. J. Appl. Physiol. 2006, 101:151-163.
14. Tanida I., Ueno T., Kominami E. LC3 and autophagy. Methods Mol. Biol. 2008, 445:77-88.
15. Wohlgemuth S.E., Julian D., Akin D.E., Fried J., Toscano K., Leeuwenburgh C., Dunn W.A. Autophagy in the heart and liver during normal aging and calorie restriction. Rejuvenation Res. 2007, 10:281-292.
16. Nakai A., Yamaguchi O., Takeda T., Higuchi Y., Hikoso S., Taniike M., Omiya S., Mizote I., Matsumura Y., Asahi M., Nishida K., Hori M., Mizushima N., Otsu K. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat. Med. 2007, 13:619-624.
17. Kuma A., Hatano M., Matsui M., Yamamoto A., Nakaya H., Yoshimori T., Ohsumi Y., Tokuhisa T., Mizushima N. The role of autophagy during the early neonatal starvation period. Nature 2004, 432:1032-1036.
18. Singh R., Kaushik S., Wang Y., Xiang Y., Novak I., Komatsu M., Tanaka K., Cuervo A.M., Czaja M.J. Autophagy regulates lipid metabolism. Nature 2009, 458:1131-1135.
19. A.H. Goldfarb, J.F. Bruno, P.J. Buckenmeyer, Intensity and duration effects of exercise on heart cAMP, phosphorylase, and glycogen, J. Appl. Physiol. 60 (1986) 1268-1273.
20. Goldfarb A.H., Kendrick Z.V. Effect of an exercise run to exhaustion on cAMP in the rat heart. J. Appl. Physiol. 1981, 51:1539-1542.
21. Coven D.L., Hu X., Cong L., Bergeron R., Shulman G.I., Hardie D.G., Young L.H. Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise. Am. J. Physiol. Endocrinol. Metab. 2003, 285:E629-636.
22. Bjorkoy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., Stenmark H., Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 2005, 171:603-614.
23. Pattingre S., Espert L., Biard-Piechaczyk M., Codogno P. Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 2008, 90:313-323.
24. Diaz-Troya S., Perez-Perez M.E., Florencio F.J., Crespo J.L. The role of TOR in autophagy regulation from yeast to plants and mammals. Autophagy 2008, 4:851-865.
25. Bolster D.R., Crozier S.J., Kimball S.R., Jefferson L.S. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J. Biol. Chem. 2002, 277:23977-23980.
26. Kim A.S., Miller E.J., Young L.H. AMP-activated protein kinase: a core signalling pathway in the heart. Acta Physiol. (Oxf.) 2009, 196:37-53.
27. Glazer H.P., Osipov R.M., Clements R.T., Sellke F.W., Bianchi C. Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling. Cell Cycle 2009, 8:1738-1746.
28. Mao K., Klionsky D.J. AMPK activates autophagy by phosphorylating ULK1. Circ. Res. 2011, 108:787-788.