Ultra-high-yield manufacture of red blood cells from hematopoietic stem cells

Tissue Engineering - Part C: Methods

Volumn 17, Issue 11, 2011, Pages 1131-1137

  Timmins, Nicholas E ^a   Athanasas, Stavrosia ^a   Günther, Marko ^a   Buntine, Penelope ^a,b   Nielsen, Lars K ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOREACTORS; BLOOD; MANUFACTURE; STEM CELLS;

AGITATED BIOREACTORS; BIOLOGICAL CAPACITY; CULTURE MEDIUM; CULTURE METHODS; DONOR SYSTEMS; EXPANSION PROCESS; FUNDAMENTAL BARRIERS; GLOBAL HEALTH; HEMATOPOIETIC STEM CELLS; HEMATOPOIETIC SYSTEMS; IN-VIVO; MEAN CELL VOLUMES; OPTIMIZED PROCESS; RED BLOOD CELL; SUPPLY-DEMAND; UMBILICAL CORD BLOOD;

CELL CULTURE;

CD34 ANTIGEN;

ANIMAL; ARTICLE; BIOREACTOR; CELL NUCLEUS; CELL PROLIFERATION; CULTURE TECHNIQUE; CYTOLOGY; ERYTHROCYTE; ERYTHROID CELL; FEEDER CELL; HEMATOPOIETIC STEM CELL; HUMAN; METABOLISM; METHODOLOGY; TIME;

ANIMALS; ANTIGENS, CD34; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL NUCLEUS; CELL PROLIFERATION; ERYTHROCYTES; ERYTHROID CELLS; FEEDER CELLS; HEMATOPOIETIC STEM CELLS; HUMANS; TIME FACTORS;

EID: 80455178750     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2011.0207     Document Type: Article

References (17)

1. Whitaker, B.I., and Henry, R.A. The 2007 Nationwide Blood Collection and Utilization Survey Report. Department of Health and Human Services, 2007. Available at internal-pdf://2007nbcus-survey-3910424833/2007nbcus-survey.pdf.
2. World Health Organization. Global Database on Blood Safety: Report 2004-2005. Geneva: World Health Organization, 2008.
3. Giarratana, M.-C., Kobari, L., Lapillonne, H., et al. Ex vivo generation of fully mature human red blood cells from he-matopoietic stem cells. Nat Biotechnol 23, 69, 2005.
4. Timmins, N.E., and Nielsen, L.K. Blood cell manufacture: current methods and future challenges. Trends Biotechnol 27, 415, 2009.
5. Miharada, K., Hiroyama, T., Sudo, K., Nagasawa, T., and Nakamura, Y. Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cells. Nat Biotechnol 24, 1255, 2006.
6. Boehm, D., Murphy, W.G., and Al-Rubeai, M. The effect of mild agitation on in vitro erythroid development. J Immunol Methods 360, 20, 2010.
7. Fujimi, A., Matsunaga, T., Kobune, M., et al. Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages. Int J He-matol 87, 339, 2008.
8. Leberbauer, C., Boulmé, F., Unfried, G., et al. Different steroids co-regulate long-term expansion versus terminal differentiation in primary human erythroid progenitors. Blood 105, 85, 2005.
9. Timmins, N.E., Palfreyman, E., Marturana, F., et al. Clinical scale ex vivo manufacture of neutrophils from hematopoietic progenitor cells. Biotechnol Bioeng 104, 832, 2009.
10. Gifford, S.C., Derganc, J., Shevkoplyas, S.S., Yoshida, T., and Bitensky, M.W. A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence. Br J Haematol 135, 395, 2006.
11. Zandstra, P.W., Eaves, C.J., and Piret, J.M. Expansion of hematopoietic progenitor cell populations in stirred suspension bioreactors of normal human bone marrow cells. Biotechnology (NY) 12, 909, 1994.
12. Sardonini, C.A., and Wu, Y.J. Expansion and differentiation of human hematopoietic cells from static cultures through small-scale bioreactors. Biotechnol Prog 9, 131, 1993.
13. Collins, P.C., Miller, W.M., and Papoutsakis, E.T. Stirred culture of peripheral and cord blood hematopoietic cells offers advantages over traditional static systems for clinically relevant applications. Biotechnol Bioeng 59, 534, 1998.
14. Hevehan, D.L., Papoutsakis, E.T., and Miller, W.M. Physiologically significant effects of pH and oxygen tension on granulopoiesis. Exp Hematol 28, 267, 2000.
15. LaIuppa, J.A., Papoutsakis, E.T., and Miller, W.M. Oxygen tension alters the effects of cytokines on the megakaryocyte, erythrocyte, and granulocyte lineages. Exp Hematol 26, 835, 1998.
16. Rogers, H.M., Yu, X., Wen, J., et al. Hypoxia alters progression of the erythroid program. Exp Hematol 36, 17, 2008.
17. Timmins, N.E., and Nielsen, L.K. Manufactured RBC-rivers of blood, or an oasis in the desert? Biotechnol Adv 2011 [Epub ahead of print]; DOI: 10.1016/j.biotechadv.2011.05.002