Optimization of propafenone analogues as antimalarial leads

Journal of Medicinal Chemistry

Volumn 54, Issue 21, 2011, Pages 7477-7485

  Lowes, David J ^a   Guiguemde, W Armand ^a   Connelly, Michele C ^a   Zhu, Fangyi ^a   Sigal, Martina S ^a   Clark, Julie A ^a   Lemoff, Andrew S ^a   Derisi, Joseph L ^b   Wilson, Emily B ^b   Guy, R Kiplin ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ION CHANNEL; PROPAFENONE;

ANTIMALARIAL ACTIVITY; ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; MICROSOME; NONHUMAN; PLASMODIUM FALCIPARUM; STRAIN DIFFERENCE;

ANIMALS; ANTIMALARIALS; CELL LINE; DRUG RESISTANCE; FEMALE; HUMANS; ION CHANNELS; MALE; MEMBRANES, ARTIFICIAL; MICE; MICROSOMES, LIVER; PARASITIC SENSITIVITY TESTS; PERMEABILITY; PLASMODIUM FALCIPARUM; PROPAFENONE; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80455144792     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2005546     Document Type: Article

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