The use of intravitreal tissue plasminogen activator in the treatment of experimental subretinal hemorrhage in the pig model

Retina

Volumn 16, Issue 6, 1996, Pages 518-524

  Boone, Diane E ^a   Culver Boldt, H ^a   Ross, Robin D ^b   Folk, James C ^a   Kimura, Alan E ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^b Retinal Consultants   (United States)

Author keywords

intravitreal; subretinal hemorrhage; subretinal surgery; tissue plasminogen activator

Indexed keywords

ALTEPLASE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL MODEL; ARTICLE; BLOOD CLOT LYSIS; CONTROLLED STUDY; DRUG EFFICACY; INTRAVITREAL DRUG ADMINISTRATION; NONHUMAN; RETINA HEMORRHAGE; SWINE; VITRECTOMY;

EID: 8044252803     PISSN: 0275004X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006982-199616060-00009     Document Type: Article

References (24)

1. De Juan E Jr, Machemer R. Vitreous surgery for hemorrhagic and fibrous complications of age-related macular degeneration. Am J Ophthalmol 1988;105:25-29.
2. Vander JF, Federman JL, Greven C, Slusher MM, Gabel VP. Surgical removal of massive subretinal hemorrhage associated with age-related macular degeneration. Ophthalmology 1991;98:23-27.
3. Wade EC, Flynn HW Jr, Olsen KR, Blumenkranz MS, Nicholson DH. Subretinal hemorrhage management by pars plana vitrectomy and internal drainage. Arch Ophthalmol 1990; 108:973-978.
4. Peyman GA, Nelson NC Jr, Alturki W, et al. Tissue plasminogen activating factor assisted removal of subretinal hemorrhage. Ophthalmic Surg 1991;22:575-582.
5. Vander JF. Tissue plasminogen activator irrigation to facilitate removal of subretinal hemorrhage during vitrectomy. Ophthalmic Surg 1992;23:361-363.
6. Toth CA, Morse LS, Hjelmeland LM, Landers MB III. Fibrin directs early retinal damage after experimental subretinal hemorrhage. Arch Ophthalmol 1991;109:723-729.
7. Johnson MW, Olsen KR, Hernandez E. Tissue plasminogen activator treatment of experimental subretinal hemorrhage. Retina 1991;11:250-258.
8. Lewis H, Resnick SC, Flannery JG, Straatsma BR. Tissue plasminogen activator treatment of experimental subretinal hemorrhage. Am J Ophthalmol 1991;111:197-204.
9. Toth CA, Benner JD, Hjelmeland LM, Landers MB III, Morse LS. Ultramicrosurgical removal of subretinal hemorrhage in cats. Am J Ophthalmol 1992;113:175-182.
10. Benner JD, Hay A, Landers MB III, Hjelmeland LM, Morse LS. Fibrinolytic-assisted removal of experimental subretinal hemorrhage within seven days reduces outer retinal degeneration. Ophthalmology 1994;101:672-681.
11. Johnson MW, Olsen KR, Hernandez E. Tissue plasminogen activator thrombolysis during surgical evacuation of experimental subretinal hemorrhage. Ophthalmology 1992;99: 515-521.
12. Ibanez HE, Williams DF, Thomas MA, et al. Surgical management of submacular hemorrhage: A series of 47 consecutive cases. Arch Ophthalmol 1995;113:62-69.
13. Kimura AE, Reddy CV, Folk JC, Farmer SG. Removal of subretinal hemorrhage facilitated by preoperative intravitreal tissue plasminogen activator. Retina 1994;14:83-84.
14. Rootman J. Vascular system of the optic nerve head and retina in the pig. Br J Ophthalmol 1971;55:808-819.
15. Bloodworth JMB Jr, Gutgesell HP Jr, Engerman RL. Retinal vasculature of the pig: Light and electron microscope studies. Exp Eye Res 1965;4:174-178.
16. De Schaepdrijver L, Simoens P, Pollet L, Lauwers H, De Laey JJ. Morphologic and clinical study of the retinal circulation in the miniature pig. B: Fluorescein angiography of the retina. Exp Eye Res 1992;54:975-985.
17. Glatt H, Machemer R. Experimental subretinal hemorrhage in rabbits. Am J Ophthalmol 1982;94:762-773.
18. Takeuchi A, Kricorian G, Yao XY, Kenny JW, Marmor MF. The rate and source of albumin entry into saline-filled experimental retinal detachments. Invest Ophthalmol Vis Sci 1994;35:3792-3798.
19. Marmor MF, Negi A, Maurice DM. Kinetics of macromolecules injected into the subretinal space. Exp Eye Res 1985; 40:687-696.
20. Bellhorn MB, Bellhorn RW, Poll DS. Permeability of fluorescein-labelled dextrans in fundus fluorescein angiography of rats and birds. Exp Eye Res 1977;24:595-605.
21. Coll GE, Sparrow JR, Marinovic A, Chang S. Effect of intravitreal tissue plasminogen activator on experimental subretinal hemorrhage. Retina 1995;15:319-326.
22. Tumbleson ME, Schmidt DA, Scholl E. Hematology and Clinical Chemistry. Leman AD, Straw B, Glock RD, Mengeling WL, Penny RHC, Scholl E, eds. Diseases of Swine. 6th ed. Aimes, IA:Iowa State University Press; 1986;34-35.
23. McLaughlin RM, Fish RE. Clinical Biochemistry and Hematology. Manning PJ, Ringler OH, Newcomer CE, eds. The Biology of the Laboratory Rabbit. 2nd ed. San Diego, CA: Academic Press; 1994; 123-124.
24. Bennett SR, Folk JC, Blodi CF, Klugman M. Factors prognostic of visual outcome in patients with subretinal hemorrhage. Am J Ophthalmol 1990;109:33-37.