Mild clinical expression of myasthenia gravis associated with autoimmune thyroid diseases

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 2, 1997, Pages 438-443

  Marinó, Michele ^a   Ricciardi, Roberta ^a   Pinchera, Aldo ^a   Barbesino, Giuseppe ^a   Manetti, Luca ^a   Chiovato, Luca ^a   Braverman, Lewis E ^c   Rossi, Bruno ^a   Muratorio, Alberto ^a   Mariotti, Stefano ^b  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; CELL HYPERPLASIA; CHILD; FEMALE; GENE EXPRESSION REGULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MYASTHENIA GRAVIS; NEUROMUSCULAR TRANSMISSION; PRIORITY JOURNAL; SEROLOGY; THYROID DISEASE; THYROID FOLLICLE CELL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AUTOIMMUNE DISEASES; CHILD; FEMALE; GRAVES DISEASE; HUMANS; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; SEVERITY OF ILLNESS INDEX; THYMOMA; THYMUS HYPERPLASIA; THYMUS NEOPLASMS; THYROID DISEASES;

EID: 8044248410     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.2.438     Document Type: Article

References (55)

1. Drachman DB. 1994 Myasthenia gravis. N Engl J Med. 330:1797-1810.
2. Kao I, Drachman DB. 1977 Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis. Science. 195:74-75.
3. Schluep M, Willcox N, Vincent A, Dhoot GK, Newsom-Davis J. 1987 Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study. Ann Neurol. 22:212-222.
4. Osserman KE. 1953 Myasthenia gravis. New York: Grune and Stratton; 80.
5. Bartoccioni E, Scuderi F, Evoli A, Provenzano C, Flamini G. 1986 Ocular myasthenia gravis: two different disease. Lancet. 1:1038-1039.
6. Zimmermann CW, Eblen F. 1993 Repertoires of autoantibodies against homologous eye muscle in ocular and generalized myasthenia gravis differ. Clin Invest. 71:445-451.
7. Seybold MB. 1983 Myasthenia gravis: a clinical and basic science review. JAMA. 205:2516-2521.
8. Garlepp MJ, Dawkins RI, Christiansen FT. 1981 Autoimmunity in ocular and generalized myasthenia gravis. J Neuroimmunol. 1:325-332.
9. Tindall RSA. 1981 Humoral immunity in myasthenia gravis: biochemical characteristics of acquired antiacetylcholine receptor antibody and clinical correlations. Ann Neurol. 10:437-447.
10. Rennie GE. 1908 Exophtalmic goitre combined with myasthenia gravis. Rev Neurol Psychiatry. 6:229-233.
11. Drachman DB. 1962 Myasthenia gravis and the thyroid gland. N Engl J Med. 15:330-333.
12. Tola MR, Caniatti LM, Casetta I, et al. 1994 Immunogenetic heterogeneity and associated autoimmune disorders in myasthenia gravis: a population-based survey in the province of Ferrara, northern Italy. Acta Neurol Scand. 90:318-323.
13. Thorlacius S, Aarli JA, Ruse T, Matre R, Johnsen H. 1989 Associated disorders in myasthenia gravis: autoimmune disease and their relation to thymectomy. Acta Neurol Scand. 80:290-295.
14. Sherbaum WA, Schumm F, Maische F, et al. 1983 Myasthenia gravis: overlap with polyendocrine autoimmunity. Klin Wochenschr. 61:509-515.
15. Aarli JA, Gilhus NE, Matre R. 1992 Myasthenia gravis with thymoma is not associated with an increased incidence of non-muscle autoimmune disorders. J Autoimmun. 11:159-562.
16. Christiensen PB, Jensen TS, Tsitopulos I, et al. 1995 Associated autoimmune disorders in myasthenia gravis. Acta Neurol Scand. 91:192-195.
17. Kiessling WR, Finke R, Kotulla P, Schleusener H. 1982 Circulating TSH-binding inhibiting immunoglobulins in myasthenia gravis. Acta Endocrinol (Copenh). 101:41-46.
18. Peacey SR, Belchetz PE. 1993 Graves' disease associated with ocular myasthenia gravis and thymic cyst. J R Soc Med. 86:297-298.
19. Sahay BM, Blendis LM, Raymond G. 1965 Relation between myasthenia gravis and thyroid disease. Br Med J. 1:762-765.
20. Millikan CH, Haines SF. 1953 The thyroid gland in relation to neuromuscular disease. Arch Intern Med. 92:5-39.
21. Oosterhuis HJGH. 1964 Studies in myasthenia gravis. I. A clinical study of 180 patients. J Neurol Sci. 1:512-546.
22. Galbraith RF, Summerskill WHJ, Murray J. 1964 Systemic lupus erythematosus, cirrhosis and ulcerative colitis after thymectomy for myasthenia gravis. N Engl J Med. 270:229-232.
23. Daroff RB. 1986 The office Tensilon test for ocular myasthenia gravis. Arch Neurol. 43:843-844.
24. Keesey JC. 1989 Electrodiagnostic approach to defects of neuromuscular transmission. Muscle Nerve. 12:613-626.
25. Braverman LE, Utiger RD. 1991 Introduction to thyrotoxicosis. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's: the thyroid. Philadelphia: Lippincott; 645-647.
26. Vitti P, Elisei R, Tonacchera M, et al. 1993 Detection of thyroid stimulating antibody using Chinese hamster ovary cells transfected with cloned human thyrotropin receptor. J Clin Endocrinol Metab. 78:499-503.
27. Burch HB, Wartofsky L. 1993 Graves' ophthalmopathy: current concepts regarding pathogenesis and management. Endocr Rev. 14:747-793.
28. Marcocci C, Vitti P, Cetani F, Catalano F, Concetti R, Pinchera A. 1991 Thyroid ultrasonography helps to identify patients with diffuse lymphocytic thyroiditis who are prone to develop hypothyroidism. J Clin Endocrinol Metab. 120:689-701.
29. Mariotti S, Pisani S, Russova A, Pinchera A. 1982 A new solid-phase immunoradiometric assay for anti-thyroglobulin autoantibody. J Endocrinol Invest. 5:227-233.
30. Mariotti S, Caturegli P, Piccolo P, Barbesino G, Pinchera A. 1990 Antithyroid peroxidase autoantibodies in thyroid diseases. J Clin Endocrinol Metab. 7:661-669.
31. Chiovato L, Vitti P, Bendinelli G, et al. 1994 Detection of antibodies blocking thyrotropin effect using hamster ovary cells transfected with the cloned human TSH receptor. J Endocrinol Invest. 17:809-816.
32. Fenzi GF, Giani C, Ceccarelli P, et al. 1986 Role of autoimmune and familial factors in goiter prevalence. Studies performed in moderately endemic area. J Endocrinol Invest. 9:161-164.
33. Aghini-Lombardi F, Antonangeli L, Vitti P, Pinchera A. 1993 Status of iodine nutrition in Italy. In: Delange F, ed. Iodine deficiency in Europe. New York: Plenum Press; 403-407.
34. Schumacher M, Camp S, Maulet Y, et al. 1986 Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence. Nature. 319:407-409.
35. Ludgate M, Swillens S, Mercken L, Vassart G. 1986 Homology between thyroglobulin and acetylcholinesterase: an explanation for pathogenesis of Graves' ophtalmopathy? Lancet. 2:219-220.
36. Ludgate ME, Dong Q, Soreq H, Mariotti S, Vassart G. 1989 The pathophysiological significance of a thyroglobulin-acetylcholinesterase shared epitope in patients with Graves' ophthalmopathy. Acta Endocrinol (Copenh). 121:38-45.
37. Ludgate M, Owada C, Pope R, Taylor P, Vassart G. 1987 Cross-reactivity antibodies to human thyroglobulin, and torpedo acetylcholinesterase in patient with Graves' ophthalmopathy. In: Pinchera A, Ingbar SH, McKenzie JM, Fenzi GF, eds. Thyroid autoimmunity. New York: Plenum Press; 271-273.
38. Weetman AP, Tse CK, Randall WR, Tsim KWR, Barnard EA. 1988 Acetylcolinesterase antibodies and thyroid autoimmunity. Clin Exp Immunol. 71:96-99.
39. Feliciello A, Porcellini A, Ciullo I, Bonavolontà G, Avvedimento EV, Fenzi G. 1993 Expression of thyrotropin-receptor in healthy and Graves' disease retro-orbital tissue. Lancet. 342:337-338.
40. Mengitsu M, Lukes YG, Nagy HB, et al. 1994 TSH receptor gene expression in retroocular fibroblasts. J Endocrinol Invest. 17:437-441.
41. Paschke R, Elisei R, Vassart G, Ludgate M. 1993 Lack of evidence supporting the presence of mRNA for the thyrotropin receptor in extra-ocular muscle. J Endocrinol Invest. 16:329-332.
42. Heufelder AE, Bahn R. 1992 Evidence for the presence of a functional TSH-receptor in retroocular fibroblasts from patients with Graves' ophthalmopathy. Exp Clin Endocrinol. 100:62-67.
43. Faryna M, Nauman J, Gardas A. 1985 Measurement of autoantibodies against human eye muscle plasma membranes in Graves' ophtalmopathy. Br Med J. 290:191-192.
44. Wang PW, Hiromatsu Y, Laryea E, Wosu L, How J, Wall JR. 1989 Immunologically mediated cytotoxicity against human eye muscle cells in Graves' ophtalmopathy. J Clin Endocrinol Metab. 64:454-460.
45. Mappouras DG, Philippou G, Haralambous S, et al. 1995 Antibodies to acetylcholinescerase cross-reacting with thyroglobulin in myasthenia gravis and Graves' disease. Clin Exp Immunol. 100:336-343.
46. Wall JR, Triller H, Boucher A, Bernard NF, Salvi M, Ludgate M. 1993 Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophtalmopathy. J Endocrinol Invest. 16:863-868.
47. Wall JR, Hayes M, Scalise D, et al. 1995 Native gel electrophoresis and isoelectric focusing of a 64-kilodalton eye muscle protein shows that it is an important target for serum autoantibodies in patients with thyroid-associated ophthalmopathy and not expressed in other skeletal muscle. J Clin Endocrinol Metab. 80:1226-1232.
48. Weetman AP, McGregor AM. 1994 Autoimmune thyroid disease: further developments in our understanding. Endocr Rev. 15:788-830.
49. Pirskanen R, Tilikainen A, Hokkanen E. 1972 Histocompatibility (HLA) antigens associated with myasthenia gravis. A preliminary report. Ann Clin Res. 4:304-406.
50. Feltkamp TEW, Van Der Berg-Loonen PM, Nijenuis LE. 1974 Myasthenia gravis, autoantibodies and HLA antigens. Br Med J. 1:131-133.
51. Ratanachaiyavong S, Fleming D, Janer M, Demaine AG, Willcox N, Newson-Davis J, et al. 1994 HLA-DPB1 polymorphism in patients with hyperthyroid Graves' disease and early onset myasthenia gravis. Autoimmunity. 17:99-104.
52. Ratanachaiyavong S, Gunn CA, Bidwell EA, Darke C, Hall R, McGregor AM. 1990 DQA2 U allele: a genetic marker for relapse of Graves' disease. Clin Endocrinol (Oxf). 32:241-251.
53. Bach JF, Caillat-Zucman S. 1993 Genetics of autoimmune endocrine disease. Springer Semin Immunopathol. 14:239-252.
54. Hawkins BR, Yu YL, Wong V, Woo E, Ip MS, Dawkins RL. 1989 Possible evidence for a variant of myasthenia gravis based on HLA and acetylcholine receptor antibody in Chinese patients. Q J Med. 70:235-241.
55. Garlepp MJ, Dawkins RL, Christiansen FT. 1983 HLA antigens, and acetylcholine receptor antibodies in penicillamine induced myasthenia gravis. Br Med J. 286:338-340.