Metabolic profiles of minimally absorbed orlistat in obese/overweight volunteers

Journal of Clinical Pharmacology

Volumn 36, Issue 11, 1996, Pages 1006-1011

  Zhi, Jianguo ^a   Melia, Angela T ^a   Funk, Christoph ^b   Viger Chougnet, Antoinette ^b   Hopfgartner, Gerard ^b   Lausecker, Berthold ^b   Wang, Ka ^a   Fulton, Jeffrey S ^a   Gabriel, Lana ^a   Mulligan, Thomas E ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EXCRETION; DRUG HALF LIFE; FEMALE; HUMAN; LIPID METABOLISM; MALE; OBESITY; ORAL DRUG ADMINISTRATION;

EID: 8044234962     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/009127009603601104     Document Type: Article

References (7)

1. Hadváry P, Lengsfeld H, Wolfer H: Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin. Biochem J 1988;256:357-361.
2. Borgström B: Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin. Biochim Biophys Acta 1988;962:308-316.
3. Drent ML, van der Veen EA: Lipase inhibition: a novel concept in the treatment of obesity. Int J Obes 1993;17:241-244.
4. Zhi J, Melia AT, Guerciolini R, Chung J, Kinbetg J, Hauptman JB, Patel IH: Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers. Clin Pharmacol Ther 1994;56:82-85.
5. Zhi J, Melia AT, Eggers H, Joly R, Patel IH: Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J Clin Pharmacol 1995;35:1103-1108.
6. Weibel EK, Hadvàry P, Hochuli E, Kupfer E, Lengsfeld H: Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation, and biological activity. J Antibiot 1987;40:1081-1085.
7. Stalder H, Schneider PR, Oesterhelt G: Tetrahydrolipstatin: thermal and hydrolytic degradation. Helv Chim Acta 1990; 73:1022-1036.