No association between α1-antichymotrypsin and familial Alzheimer's disease

Annals of the New York Academy of Sciences

Volumn 802, Issue , 1996, Pages 35-41

  Haines, Jonathan L ^a   Pritchard, Meredyth L ^b   Saunders, Ann M ^b   Schildkraut, Joellen M ^c   Growdon, John H ^a   Gaskell, Peter C ^b   Farrer, Lindsay A ^d   Auerbach, Sanford A ^d   Gusella, James F ^a   Locke, Patricia A ^a   Rosi, Barbara L ^b   Yamaoka, Larry ^b   Small, Gary W ^e   Conneally, P Michael ^f   Roses, Allen D ^b   Pericak Vance, Margaret ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c DUKE CANCER INSTITUTE   (United States)

^d BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f INDIANA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; AMYLOID; APOLIPOPROTEIN E;

ALZHEIMER DISEASE; CHROMOSOME 19Q; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; FAMILIAL DISEASE; GENETIC POLYMORPHISM; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; ONSET AGE; PATHOPHYSIOLOGY; SENILE PLAQUE;

EID: 8044234960     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb32596.x     Document Type: Conference Paper

References (21)

1. MAX, W. 1993. The economic impact of Alzheimer's disease. Neurology 43(Suppl. 4): 56-510.
2. HAINES, J. L. 1991. Invited editorial: The genetics of Alzheimer disease - A teasing problem. Am. J. Hum. Genet. 48: 1021-1025.
3. GOATE, A., M.-C. CHARTIER-HARLIN, M. MULLAN, et al. 1991. Segregation of a missense mutation of the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349: 704-706.
4. SHERRINGTON, R., E. I. ROGAEV, Y. LIANG, et al. 1995. Cloning of a novel gene bearing missense mutations in early familial Alzheimer disease. Nature 375: 754-760.
5. LEVY-LEHAD, E., W. WASCO, P. POORKAJ, et al. 1995. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269: 973-977.
6. ROGAEV, E. I., R. SHERRINGTON, E. A. ROGAEVA, et al. 1995. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376: 600-662.
7. PERICAK-VANCE, M. A., J. L. BEBOUT, P. C. GASKELL, et al. 1991. Linkage studies in familial Alzheimer's disease: Evidence for chromosome 19 linkage. Am. J. Hum. Genet. 48: 1034-1050.
8. STRITTMATTER, W. J., A. M. SAUNDERS, D. SCHMECHEL, et al. 1993. Apolipoprotein E: High avidity binding to -amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc. Natl. Acad. Sci. USA 90: 1977-1981.
9. CORDER, E. H., A. M. SAUNDERS, W. J. STRITTMATTER, et al. 1993. Apolipoprotein E4 gene dose and the risk of Alzheimer disease in late onset families. Science 261: 921-923.
10. SAUNDERS, A. M., W. J. STRITTMATTER, D. SCHMECHEL, et al. 1993. Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 1467-1472.
11. ROSES, A. D. & M. A. PERICAK-VANCE. 1996. Alzheimer's disease and other dementias. In Emery and Rimoin's Principles and Practice of Medical Genetics, 3rd ed. In press.
12. CORDER, E. H., A. M. SAUNDERS, N. J. RISCH, W. J. STRITTMATTER, D. E. SCHMECHEL, P. C. GASKELL, J. B. RIMMLER, P. A. LOCKE & P. M. CONNEALLY, K. E. SCHMADER, G. W. SMALL, A. D. ROSES, J. L. HAINES & M. A. PERICAK-VANCE. 1994. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat. Genet. 7: 180-184.
13. ROSES, A. D., B. DEVLIN, P. M. CONNEALLY, et al. 1996. Measuring the genetic contribution of APOE in late-onset Alzheimer disease (AD). Am. J. Hum. Genet. In press.
14. ABRAHAM, C. R., D. J. SELKOE & H. POTTER. 1988. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's. Cell 52: 487-501.
15. ABRAHAM, C. R., T. SHIRAHAMA, & H. POTTER. 1990. Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Neurobiol. Aging 11: 123-129.
16. KAMBOH, M. I., D. K. SANGHERA, R. E. FERRELL, & S. T. DEKOSKY. 1995. APOE ∈4-associated Alzheimer's disease risk in modified by α-antichymotripsin polymorphism. Natl. Genet. 10: 486-488.
17. MCKHANN, G., D. DRACHMAN, M. FOLSTEIN, et al. 1984. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34: 939-944.
18. LOCKE, P., P. M. CONNEALLY, R. E. TANZI, et al. 1995. APOE and Alzheimer disease: Examination of allelic association and effect on age at-onset in both early and late-onset cases. Genet. Epidemiol. 12: 83-92.
19. LATHROP, R. M., J. M. LALOUEL, C. JULIER & J. OTT. 1984. Multi-locus linkage analysis in humans: Detection of linkage and estimation of recombination. Am. J. Hum. Genet. 37: 482-498.
20. WEEKS, D. E. & K. LANGE. 1988. The affected-pedigree-member method of linkage analysis. Am. J. Hum. Genet. 42: 315-326.
21. HAINES, J. L., M. L. PRITCHARD, A. M. SAUNDERS, J. M. SCHILDKRAUT, J. H. GROWDON, P. C. GASKELL, L. A. FARRER, S. A. AUERBACH, J. F. GUSELLA, P. A. LOCKE, B. L. ROSI L. YAMAOKA, G. W. SMALL, P. M. COMMEANNLY, A. D. ROSES & M. A. PERICAK-VAN. 1996. No genetic effect of α1-antichymotrypsin in Alzheimer disease. Genomics 33: 53-56.