In vivo receptor characterization of neuropeptide Y-induced effects in consecutive vascular sections of cat skeletal muscle

British Journal of Pharmacology

Volumn 120, Issue 3, 1997, Pages 387-392

  Ekelund, Ulf ^a   Erlinge, David ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Arteriole; BIBP3226; Microcirculation; Neuropeptide Y; Vein; Y1 receptor

Indexed keywords

NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y [13-36]; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y3 RECEPTOR; PEPTIDE YY;

ANIMAL TISSUE; ARTERIOLE; ARTERY RESISTANCE; ARTICLE; BODY FLUID; CAPILLARY PRESSURE; CAT; CONTROLLED STUDY; GASTROCNEMIUS MUSCLE; MALE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; VASCULAR RESISTANCE; VASOCONSTRICTION; VEIN;

ANIMALS; ARGININE; ARTERIES; BLOOD VESSELS; CATS; DOSE-RESPONSE RELATIONSHIP, DRUG; HINDLIMB; MALE; MICROCIRCULATION; MUSCLE, SKELETAL; NEUROPEPTIDE Y; RECEPTORS, NEUROPEPTIDE Y; REGIONAL BLOOD FLOW; SYMPATHECTOMY; VASCULAR RESISTANCE; VASOCONSTRICTOR AGENTS; VEINS;

EID: 8044233043     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700908     Document Type: Article

References (40)

1. BJÖRNBERG, J., GRÄNDE, P.-O., MASPERS, M. & MELLANDER, S. (1988). Site of autoregulatory reactions in the vascular bed of cat skeletal muscle as determined with a new technique for segmental vascular resistance recordings. Acta Physiol. Scand., 133, 199-210.
2. CORDER, R., LOWRY, P.J., WILKINSON, S.J. & RAMAGE, A.G. (1986). Comparison of the haemodynamic actions of neuropeptide Y, angiotensin II and noradrenaline in anaesthetised cats. Eur. J. Pharmacol., 121, 25-30.
3. DOODS, H.N., WIENEN, W., ENTZEROTH, M., RUDOLF, K., EBERLEIN, W., ENGEL, W. & WIELAND, H.A. (1995). Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP 3226. J. Pharmacol. Exp. Ther., 275, 136-142.
4. EDVINSSON, L., HÅKANSON, R., WAHLESTEDT, C. & UDDMAN, R. (1987). Effects of neuropeptide Y on the cardiovascular system. Trends Pharmacol. Sci., 8, 231-235.
5. EKELUND, U. (1996). Effects of angiotensin-converting enzyme inhibition on arterial, venous and capillary functions in cat skeletal muscle in vivo. Acta Physiol. Scand., 158, 29-37.
6. A receptor blockade on arterial, venous and capillary functions in skeletal muscle. Acta Physiol. Scand., 148, 273-283.
7. ERLINGE, D. (1994). The Sympathetic Cotransmitters Neuropeptide Y and A TP in the Regulation of the Vascular Smooth Muscle Cell. Mitogenic Effects, Receptors and Second Messengers; Aspects on Clinical Pathophysiology. Thesis, Lund University, Faculty of Medicine.
8. 1 receptor antisense oligodeoxynucleotide specifically inhibits neuropeptide Y-evoked vasoconstriction. Eur. J. Pharmacol., 240, 77-80.
9. GERALD, C., WALKER, M.W., CRISCIONE, L., GUSTAFSON, E.L., BATZL-HARTMANN, C., SMITH, K.E., VAYSSE, P., DURKIN, M.M., LAZ, T.M., LINEMAYER, D.L., SCHAFFHAUSER, A.O., WHITEBREAD, S., HOFBAUER, K.G., TABER, R.I., BRANCHECK, T.A. & WEINSHANK, R.L. (1996). A receptor subtype involved in neuropeptide-Y-induced food intake. Nature, 382, 168-171.
10. GRÄNDE, P.-O. & BORGSTRÖM, P. (1978). An electronic differential pressure flowmeter and a resistance meter for continuous measurement of vascular resistance. Acta Physiol. Scand., 102, 224-230.
11. GRUNDEMAR, L. & HÅKANSON, R. (1994). Neuropeptide Y effector systems: perspectives for drug development. Trends Pharmacol. Sci., 15, 153-159.
12. GRUNDEMAR, L., MÖRNER, J., HÖGESTEDT, E., WAHLESTEDT, C. & HÅKANSON, R. (1992). Characterization of vascular receptors for neuropeptide Y. Br. J. Pharmacol., 105, 45-50.
13. HERZOG, H., HORT, Y.J., BALL, H.J., HAYES, G., SHINE, J. & SELBIE, L.A. (1992). Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc. Natl. Acad. Sci. U.S.A., 89, 5794-5798.
14. JOSHUA, I.G. (1991). Neuropeptide Y-induced constriction in small resistance vessels of skeletal muscle. Peptides, 12, 37-41.
15. KIM, D., WALTER, R.D., KOBAYASHI, I., DANIELS, A.J. & DURAN, W.N. (1994). Microcirculatory dynamics of neuropeptide Y. Microvasc. Res., 48, 124-134.
16. KOBARI M., FUKUUCHI, Y., TOMITA, M., TANAHASHI, N., YAMAWAKI, T., TAKEDA, H. & MATOUSA, S. (1993). Transient cerebral vasodilatory effect of neuropeptide Y mediated by nitric oxide. Brain Res. Bull., 31, 443-448.
17. 1 type. J. Biol. Chem., 267, 10935-10938.
18. LIND, H., ERLINGE, D., BRUNKWALL, J. & EDVINSSON, L. (1995). Transient vasodilation induced by neuropeptide Y and inhibited by L-NMMA in human subcutaneous blood vessels. Pharmacol. Toxicol., 76, suppl. IV, 57.
19. LUNDBERG, J.M. & MODIN, A. (1995). Inhibition of sympathetic vasoconstriction in control pigs in vivo by the neuropeptide Y-Y1 receptor antagonist BIBP 3226. Br. J. Pharmacol., 116, 2971-2982.
20. LUNDBERG, J.M., TERENIUS, L., HÖKFELT, T., MARTLING, C.-R., TATEMOTO, K., MUTT, V., POLAK, J., BLOOM, S. & GOLDSTEIN, M. (1982). Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic functions. Acta Physiol. Scand., 116, 477-480.
21. LUNDELL, I., BLOMQVIST, A.G., BERGLUND, M., SCHOBER, D.A., JOHNSON, D., STATNICK, M.A., GADSKI, R.A., GEHLERT, D.R. & LARHAMMAR, D. (1995). Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J. Biol. Chem., 270, 29123-29128.
22. MASPERS, M., BJÖRNBERG, J., GRÄNDE, P.-O. & MELLANDER, S. (1990a). Sympathetic α-adrenergic control of large-bore arterial vessels, arterioles and veins, and of capillary pressure and fluid exchange in whole-organ cat skeletal muscle. Acta Physiol. Scand., 138, 509-521.
23. MASPERS, M., BJÖRNBERG, J. & MELLANDER, S. (1990b). Relation between capillary pressure and vascular tone over the range from maximum dilatation to maximum constriction in cat skeletal muscle. Acta Physiol. Scand., 140, 73-80.
24. MELLANDER, S., BJÖRNBERG, J., MASPERS, M. & MYRHAGE, R. (1987a). Method for continuous recording of hydrostatic exchange vessel pressure in cat skeletal muscle. Acta Physiol. Scand., 129, 325-335.
25. MELLANDER, S., MASPERS, M., BJÖRNBERG, J. & ANDERSSON, L.-O. (1987b). Autoregulation of capillary pressure and filtration in cat skeletal muscle in states of normal and reduced vascular tone. Acta Physiol. Scand., 129, 337-351.
26. MINKES, R.K., MACMILLAN, L.A., BELLAN, J.A., KERSTEIN, M.D., MCNAMARA, D.B. & KADOWITZ, P.J. (1989). Analysis of regional resistances to endothelin in hindquarters vascular bed of cats. Am. J. Physiol., 256, H598-H602.
27. MODIN, A., PERNOW, J. & LUNDBERG, J.M. (1991). Evidence for two neuropeptide Y receptors mediating vasoconstriction. Eur. J. Pharmacol., 203, 165-171.
28. MORRIS, J.L. (1994). Selective constriction of small cutaneous arteries by NPY matches distribution of NPY in sympathetic axons. Regul. Peptides, 49, 225-236.
29. OWEN, M.P. (1993). Similarities and differences in the postjunctional role for neuropeptide Y in sympathetic vasomotor control of large vs. small arteries of rabbit renal and ear vasculature. J. Pharmacol. Exp. Ther., 265, 887-895.
30. PERNOW, J., KAHAN, T., HJEMDAHL, P. & LUNDBERG, J.M. (1988a). Possible involvement of neuropeptide Y in sympathetic vascular control of canine skeletal muscle. Acta Physiol. Scand., 132, 43-50.
31. PERNOW, J., KAHAN, T. & LUNDBERG, J.M. (1988b). Neuropeptide Y and reserpine-resistant vasoconstriction evoked by sympathetic nerve stimulation in the dog skeletal muscle. Br. J. Pharmacol., 94, 952-960.
32. PERNOW, J., ÖHLEN, A., HÖKFELT, T., NILSSON, O. & LUNDBERG, J.M. (1987). Neuropeptide Y: presence in perivascular noradrenergic neurons and vasoconstrictor effects on skeletal muscle blood vessels in experimental animals and man. Regul. Peptides, 19, 313-324.
33. 31]-NPY-(24-36), with functional specificity for the presynaptic (Y2) receptor. Eur. J. Pharmacol., 267, 253-262.
34. ROSE, P.M., FERNANDES, P., LYNCH, J.S., FRAZIER, S.T., FISHER, S.M., KODUKUA, K., KLENZIE, B. & SEETHALA, R. (1995). Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J. Biol. Chem., 270, 22661-22664.
35. RUDOLF, K., EBERLEIN, W., ENGEL, W., WIELAND, H.A., WILLIM, K.D., ENTZEROTH, M., WIENEN, W., BECK-SICKINGER, A.G. & DOODS, H.N. (1994). The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226. Eur. J. Pharmacol., 271, R11-R13.
36. SHEIKH, S.P., ROACH, E., FUHLENDORFF, J. & WILLIAMS, J.A. (1991). Localization of Y1 receptors for NPY and PYY on vascular smooth muscle cells in rat pancreas. Am. J. Physiol., 260, G250-G257.
37. SUNDLER, F., BÖTTCHER, G., EKBLAD, E. & HÅKANSON, R. (1993). PP, PYY, and NPY: occurrence and distribution in the periphery. In The Biology of Neuropeptide Y and Related Peptides, ed. Colmers, W.F. & Wahlestedt, C. Tolowa: Humana Press Inc.
38. WAHLESTEDT, C. & REIS, D.J. (1993). Neuropeptide Y-related peptides and their receptors - are the receptors potential therapeutic drug targets? Ann. Rev. Pharmacol. Toxicol., 32, 309-352.
39. WEINBERG, D.H., SIRINATHSINGHJI, D.J.S., TAN, C.P., SHIAO, L.-L., MORIN, N., RIGBY, M.R., HEAVENS, R.H., RAPAPORT, D.R., BAYNE, M.L., CASCIERI, M.A., STRADER, C.D., LINEMEYER, D.L. & MACNEIL, D.J. (1996). Cloning and expression of a novel neuropeptide Y receptor. J. Biol. Chem., 271, 16435-16438.
40. WIELAND, H.A., WILLIM, K.D., ENTZEROTH, M., WIENEN, W., RUDOLF, K., EBERLEIN, W., ENGEL, W. & DOODS, H.N. (1995). Subtype selectivity and antagonist profile of the nonpeptide Y1 receptor antagonist BIBP 3226. J. Pharmacol. Exp. Ther., 275, 143-149.