Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence

Journal of Visualized Experiments

Volumn , Issue 51, 2011, Pages

  Sakadžić, Sava ^a   Roussakis, Emmanuel ^b   Yaseen, Mohammad A ^a   Mandeville, Emiri T ^a   Srinivasan, Vivek J ^a   Arai, Ken ^a   Ruvinskaya, Svetlana ^a   Wu, Weicheng ^a   Devor, Anna ^a,c   Lo, Eng H ^a   Vinogradov, Sergei A ^b   Boas, David A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Blood; Brain; Imaging; Issue 51; Neuroscience; Oxygenation; Phosphorescence

Indexed keywords

EID: 80355139310     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/1694     Document Type: Article

References (7)

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3. Lebedev, A.Y., Cheprakov, A.V., Sakadzic, S., Boas, D.A., Wilson, D.F., & Vinogradov, S.A. Dendritic Phosphorescent Probes for Oxygen Imaging in Biological Systems. Applied Materials & Interfaces (2009).
4. Finikova, O.S., Lebedev, A.Y., Aprelev, A., Troxler, T., Gao, F., Garnacho, C., Muro, S., Hochstrasser, R.M., & Vinogradov, S.A. Oxygen microscopy by two-photon-excited phosphorescence. Chemphyschem 9:1673-1679 (2008).
5. Sakadžić, S., Yuan, S., Dilekoz, E., Ruvinskaya, S., Vinogradov, S.A., Ayata, C., & Boas, D.A. Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression, Appl Opt 48(10): D169-D177 (2009).
6. Yaseen, M.A., Srinivasan, V.J., Sakadzic, S., Wu, W., Ruvinskaya, S., Vinogradov, S.A., & Boas, D.A. Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy. Opt Express 17(25): 22341-22350 (2009).
7. Sakadzic, S., Roussakis, E., Yaseen, M.A., Mandeville, E.T., Srinivasan, V.J., Arai, K., Ruvinskaya, S., Devor, A., Lo, E.H., Vinogradov, S.A., & Boas, D.A. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods 7(9):755-759 (2010).