Multicentric osteosarcoma: Clinicopathologic and radiographic study of 56 cases

American Journal of Clinical Pathology

Volumn 136, Issue 5, 2011, Pages 799-807

  Corradi, Domenico ^a   Wenger, Doris E ^b   Bertoni, Franco ^c   Bacchini, Patrizia ^c   Bosio, Silvia ^a   Goldoni, Matteo ^a   Unni, K Krishnan ^b   Sim, Franklin H ^b   Inwards, Carrie Y ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b MAYO CLINIC   (United States)

^c RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

Chemotherapy; Computed tomography; Histopathology; Magnetic resonance imaging; Metachronous; Multicentric osteosarcoma; Prognosis; Radiographs; Surgery; Synchronous

Indexed keywords

CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; IFOSFAMIDE; METHOTREXATE; VINCRISTINE;

ADOLESCENT; ADULT; AGED; ARTICLE; BONE RADIOGRAPHY; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CHILD; CLINICAL FEATURE; DRUG MEGADOSE; FEMALE; FEMUR; HUMAN; HUMAN TISSUE; HUMERUS; MAJOR CLINICAL STUDY; MALE; MULTICENTRIC OSTEOSARCOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOSARCOMA; OVERALL SURVIVAL; PELVIS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; RIB; SCHOOL CHILD; SECOND CANCER; SKULL; SPINE; SURVIVAL TIME; TIBIA; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; BONE NEOPLASMS; CHILD; CHILD, PRESCHOOL; FEMALE; FEMORAL NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; NEOPLASMS, SECOND PRIMARY; OSTEOSARCOMA; SURVIVORS;

EID: 80355138133     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCP0V0OATKCNAZP     Document Type: Article

References (25)

1. Dorfman H, Czerniak B, Kotz R, et al. WHO classification of tumours of bone: introduction. In: Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon, France: IARC Press; 2002:227-232.
2. Maggia F. Experimental and Clinical Progress in Cancer Chemotherapy. Boston, MA: Nijhoff; 1985.
3. Fitzgerald RH Jr, Dahlin DC, Sim FH. Multiple metachronous osteogenic sarcoma: report of twelve cases with two long-term survivors. J Bone Joint Surg Am. 1973;55:595-605.
4. Parham DM, Pratt CB, Parvey LS, et al. Childhood multifocal osteosarcoma: clinicopathologic and radiologic correlates. Cancer. 1985;55:2653-2658. (Pubitemid 15092154)
5. Price CH, Truscott DE. Multifocal osteogenic sarcoma: report of a case. J Bone Joint Surg Br. 1957;39-B:524-533.
6. Jaffe N, Pearson P, Yasko AW, et al. Single and multiple metachronous osteosarcoma tumors after therapy. Cancer. 2003;98:2457-2466. (Pubitemid 37466661)
7. Mahoney JP, Spanier SS, Morris JL. Multifocal osteosarcoma: a case report with review of the literature. Cancer. 1979;44:1897-1907. (Pubitemid 10141972)
8. Daffner RH, Kennedy SL, Fox KR, et al. Synchronous multicentric osteosarcoma: the case for metastases. Skeletal Radiol. 1997;26:569-578. (Pubitemid 27472471)
9. Tillotson C, Rosenberg A, Gebhardt M, et al. Postradiation multicentric osteosarcoma. Cancer. 1988;62:67-71.
10. Lam KS, Wu PC, Chan FL, et al. Multicentric sclerosing osteosarcoma: a rare cause of cranial nerve palsy. Clin Oncol. 1984;10:281-287. (Pubitemid 15091920)
11. Bhutani M, Pathak AK, Sengar M, et al. Multifocal osteosarcoma involving unusual sites. Cancer Invest. 2006;24:278-282.
12. Bacci G, Picci P, Ferrari S, et al. Synchronous multifocal osteosarcoma: results in twelve patients treated with neoadjuvant chemotherapy and simultaneous resection of all involved bones. Ann Oncol. 1996;7:864-866. (Pubitemid 26345881)
13. Bacci G, Fabbri N, Balladelli A, et al. Treatment and prognosis for synchronous multifocal osteosarcoma in 42 patients. J Bone Joint Surg Br. 2006;88:1071-1075.
14. Gaffney R, Unni KK, Sim FH, et al. Follow-up study of long-term survivors of osteosarcoma in the prechemotherapy era. Hum Pathol. 2006;37:1009-1014. (Pubitemid 44080805)
15. Unni KK, Dahlin DC. Grading of bone tumors. Semin Diagn Pathol. 1984;1:165-172. (Pubitemid 15204173)
16. Unni K. Osteosarcoma. In: Unni K, ed. Dahlin's Bone Tumors. 5th ed. Philadelphia, PA: Lippincott-Raven; 1996:143-183.
17. Rosen G, Caparros B, Huvos AG, et al. Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer. 1982;49:1221-1230. (Pubitemid 12187826)
18. Hansen MF, Nellissery MJ, Bhatia P. Common mechanisms of osteosarcoma and Paget's disease. J Bone Miner Res. 1999;14(suppl 2):39-44. (Pubitemid 29455797)
19. Dahlin DC, Coventry MB. Osteogenic sarcoma: a study of six hundred cases. J Bone Joint Surg Am. 1967;49:101-110.
20. Silverman G. Multiple osteosarcoma. Arch Pathol. 1936;21:88-95.
21. Jeffree GM, Price CH, Sissons HA. The metastatic patterns of osteosarcoma. Br J Cancer. 1975;32:87-107.
22. Unni KK, Inwards CY, Bridge JA, et al. Tumors of the Bones and Joints. Washington, DC: American Registry of Pathology; 2005. Atlas of Tumor Pathology; Fourth series; Fascicle 2.
23. McKenna R, Schwinn C, Soong K, et al. Sarcomata of the osteogenic series (osteosarcoma, fibrosarcoma, chondrosarcoma, parosteal osteogenic sarcoma and sarcomata arising in abnormal bone): an analysis of 522 cases. J Bone Joint Surg. 1966;48A:1-26.
24. Hauben EI, Arends J, Vandenbroucke JP, et al. Multiple primary malignancies in osteosarcoma patients: incidence and predictive value of osteosarcoma subtype for cancer syndromes related with osteosarcoma. Eur J Hum Genet. 2003;11:611-618. (Pubitemid 37038776)
25. Pratt CB, Meyer WH, Luo X, et al. Second malignant neoplasms occurring in survivors of osteosarcoma. Cancer. 1997;80:960-965. (Pubitemid 27360479)