GLUT 5 is not over-expressed in breast cancer cells and patient breast cancer tissues

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Gowrishankar, Gayatri ^a   Zitzmann Kolbe, Sabine ^b   Junutula, Anitha ^a   Reeves, Robert ^a   Levi, Jelena ^a   Srinivasan, Ananth ^b   Bruus Jensen, Kjerstin ^b   Cyr, John ^b   Dinkelborg, Ludger ^b   Gambhir, Sanjiv S ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYER PHARMA AG   (Germany)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHALASIN B; FLUORODEOXYGLUCOSE F 18; FRUCTOSE; GLUCOSE TRANSPORTER 5; MESSENGER RNA; SMALL INTERFERING RNA; PRIMER DNA; SLC2A5 PROTEIN, HUMAN;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER TISSUE; CELL IMMORTALIZATION; CONTROLLED STUDY; HEXOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; TISSUE MICROARRAY; BREAST TUMOR; FEMALE; GENE SILENCING; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; TUMOR CELL LINE;

BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE, TUMOR; CYTOCHALASIN B; DNA PRIMERS; FEMALE; FRUCTOSE; GENE KNOCKDOWN TECHNIQUES; GLUCOSE TRANSPORTER TYPE 5; HUMANS; IMMUNOHISTOCHEMISTRY; RNA, SMALL INTERFERING;

EID: 80355136456     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026902     Document Type: Article

References (25)

1. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, et al. (2005) Cancer statistics, 2005. CA Cancer J Clin 55: 10-30.
2. Alavi A, Kung JW, Zhuang H, (2004) Implications of PET based molecular imaging on the current and future practice of medicine. Semin Nucl Med 34: 56-69.
3. Kelloff GJ, Hoffman JM, Johnson B, Scher HI, Siegel BA, et al. (2005) Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development. Clin Cancer Res 11: 2785-2808.
4. Kostakoglu L, Goldsmith SJ, (2003) 18F-FDG PET evaluation of the response to therapy for lymphoma and for breast, lung, and colorectal carcinoma. J Nucl Med 44: 224-239.
5. Buck AK, Halter G, Schirrmeister H, Kotzerke J, Wurziger I, et al. (2003) Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG. J Nucl Med 44: 1426-1431.
6. Avril N, Rose CA, Schelling M, Dose J, Kuhn W, et al. (2000) Breast imaging with positron emission tomography and fluorine-18 fluorodeoxyglucose: use and limitations. J Clin Oncol 18: 3495-3502.
7. Gould GW, Holman GD, (1993) The glucose transporter family: structure, function and tissue-specific expression. Biochem J 295 (Pt 2): 329-341.
8. Joost HG, Thorens B, (2001) The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). Mol Membr Biol 18: 247-256.
9. James DE, Piper RC, (1994) Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4. J Cell Biol 126: 1123-1126.
10. Jung CY, (1998) Proteins that interact with facilitative glucose transporters: implication for function. Exp Physiol 83: 267-273.
11. Lazar V, Bidart JM, Caillou B, Mahe C, Lacroix L, et al. (1999) Expression of the Na+/I- symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J Clin Endocrinol Metab 84: 3228-3234.
12. Zeng H, Parthasarathy R, Rampal AL, Jung CY, (1996) Proposed structure of putative glucose channel in GLUT1 facilitative glucose transporter. Biophys J 70: 14-21.
13. Brown RS, Wahl RL, (1993) Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study. Cancer 72: 2979-2985.
14. Zamora-Leon SP, Golde DW, Concha II, Rivas CI, Delgado-Lopez F, et al. (1996) Expression of the fructose transporter GLUT5 in human breast cancer. Proc Natl Acad Sci U S A 93: 1847-1852.
15. Godoy A, Ulloa V, Rodriguez F, Reinicke K, Yanez AJ, et al. (2006) Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. J Cell Physiol 207: 614-627.
16. Chan KK, Chan JY, Chung KK, Fung KP, (2004) Inhibition of cell proliferation in human breast tumor cells by antisense oligonucleotides against facilitative glucose transporter 5. J Cell Biochem 93: 1134-1142.
17. Burant CF, Takeda J, Brot-Laroche E, Bell GI, Davidson NO, (1992) Fructose transporter in human spermatozoa and small intestine is GLUT5. J Biol Chem 267: 14523-14526.
18. Proceedings of the National Academy of Sciences of the United States of America (1996) Correction for vol. 93, 1847 p. Proceedings of the National Academy of Sciences of the United States of America 93: 15522.
19. Grover-McKay M, Walsh SA, Seftor EA, Thomas PA, Hendrix MJ, (1998) Role for glucose transporter 1 protein in human breast cancer. Pathol Oncol Res 4: 115-120.
20. Ponten F, Jirstrom K, Uhlen M, (2008) The Human Protein Atlas--a tool for pathology. J Pathol 216: 387-393.
21. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, et al. (2009) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457: 910-914.
22. Levi J, Cheng Z, Gheysens O, Patel M, Chan CT, et al. (2007) Fluorescent fructose derivatives for imaging breast cancer cells. Bioconjug Chem 18: 628-634.
23. Concha, II, Velasquez FV, Martinez JM, Angulo C, Droppelmann A, et al. (1997) Human erythrocytes express GLUT5 and transport fructose. Blood 89: 4190-4195.
24. Keshari KR, Wilson DM, Chen AP, Bok R, Larson PE, et al. (2009) Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc 131: 17591-17596.
25. Trayner BJ, Grant TN, West FG, Cheeseman CI, (2009) Synthesis and characterization of 6-deoxy-6-fluoro-D-fructose as a potential compound for imaging breast cancer with PET. Bioorg Med Chem 17: 5488-5495.