HLA-IG based artificial antigen presenting cells for efficient ex vivo expansion of human CTL

Journal of Visualized Experiments

Volumn , Issue 50, 2011, Pages

  Chiu, Yen Ling ^a,b   Schneck, Jonathan P ^a   Oelke, Mathias ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Far Eastern Memorial Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80355130078     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/2801     Document Type: Article

References (5)

1. Walter, E. A. et al., Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 333 (16), 1038 (1995).
2. Rosenberg, S. A. et al., Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer 8 (4), 299 (2008).
3. Ndhlovu, Z. M., Oelke, M., Schneck, J. P., and Griffin, D. E., Dynamic regulation of functionally distinct virus-specific T cells. Proc Natl Acad Sci U S A 107 (8), 3669.
4. Oelke, M. et al., Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig-coated artificial antigen-presenting cells. Nat Med 9 (5), 619 (2003).
5. Oelke, M. et al., Artificial antigen-presenting cells: artificial solution for real diseases. Trends Mol Med 11 (9), 412 (2005).