Molecular analysis of hepatitis B virus (HBV) in an HIV co-infected patient with reactivation of occult HBV infection following discontinuation of lamivudine-including antiretroviral therapy

BMC Infectious Diseases

Volumn 11, Issue , 2011, Pages

  Costantini, Andrea ^a   Marinelli, Katia ^a   Biagioni, Giulia ^a   Monachetti, Alessia ^a   Ferreri, Monica L ^a   Butini, Luca ^a   Montroni, Maria ^a   Manzin, Aldo ^b   Bagnarelli, Patrizia ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ATAZANAVIR; DARUNAVIR; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; HEPATITIS B SURFACE ANTIGEN; LAMIVUDINE; NEVIRAPINE; SAQUINAVIR; STAVUDINE; TENOFOVIR; ZIDOVUDINE; ANTIVIRUS AGENT; VIRUS DNA;

ADULT; ARTICLE; CASE REPORT; DIARRHEA; DISEASE SEVERITY; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; GENETIC VARIABILITY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MIXED INFECTION; NUCLEOTIDE SEQUENCE; RASH; SEQUENCE ANALYSIS; TREATMENT OUTCOME; VIRUS ISOLATION; VIRUS MUTATION; VIRUS REACTIVATION; CHEMISTRY; CLASSIFICATION; DNA SEQUENCE; GENETICS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; IMMUNOLOGY; ISOLATION AND PURIFICATION; METHODOLOGY; MIDDLE AGED; MISSENSE MUTATION; MOLECULAR EVOLUTION; MOLECULAR GENETICS; VIROLOGY;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; ANTIVIRAL AGENTS; DNA, VIRAL; EVOLUTION, MOLECULAR; FEMALE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HIV INFECTIONS; HUMANS; LAMIVUDINE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; SEQUENCE ANALYSIS, DNA;

EID: 80355125217     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-11-310     Document Type: Article

References (26)

1. Raimondo G, Allain JP, Brunetto MR, Buendia MA, Chen DS, Colombo M, Craxì A, Donato F, Ferrari C, Gaeta GB, Gerlich WH, Levrero M, Locarnini S, Michalak T, Mondelli MU, Pawlotsky JM, Pollicino T, Prati D, Puoti M, Samuel D, Shouval D, Smedile A, Squadrito G, Trépo C, Villa E, Will H, Zanetti AR, Zoulim F. Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol 2008, 49:652-657. 10.1016/j.jhep.2008.07.014, 18715666.
2. Raimondo G, Pollicino T, Cacciola I, Squadrito G. Occult hepatitis B virus infection. J Hepatol 2007, 46:160-170. 10.1016/j.jhep.2006.10.007, 17112622.
3. Neau D, Winnock M, Galpérine T, Jouvencel AC, Castéra L, Legrand E, Tranchant E, Balestre E, Lacoste D, Ragnaud JM, Dupon M, Lafon ME, Dabis F, . for the Grupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA) Isolated antibodies against the core antigen of hepatitis B virus in HIV-infected patients. HIV Med 2004, 5:171-173. 10.1111/j.1468-1293.2004.00206.x, 15139983, for the Grupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA).
4. Pérez-Rodríguez MT, Sopeña P, Crespo M, Rivera A, Gonzáles del Blanco T, Ocampo A, Martínez-Vázquez C. Clinical significance of "anti-HBc alone" in human immunodeficiency virus-positive patients. World J Gastroenterol 2009, 15:1237-1241. 10.3748/wjg.15.1237, 2658847, 19291824.
5. Morsica G, Ancarani F, Bagaglio S, Maracci M, Cicconi P, Cozzi Lepri A, Antonucci G, Bruno R, Santantonio T, Tacconi L, Baldelli F, Piscopo R, Santoro D, Lazzarin A, D'Arminio Monforte A, . for the HepaICONA and the ICONA Study Groups Occult hepatitis B virus infection in a cohort of HIV-positive patients: correlation with hepatitis C virus infection, virological and immunological features. Infection 2009, 37:445-449. 10.1007/s15010-008-8194-9, 19669092, for the HepaICONA and the ICONA Study Groups.
6. Lo Re V, Frank I, Gross R, Dockter J, Linnen JM, Giachetti C, Tebas P, Stern J, Synnestvedt M, Russell Localio A, Kostman JR, Strom BL. Prevalence, risk factors, and outcomes of occult hepatitis B virus infection among HIV-infected patients. J AIDS 2007, 44:315-320.
7. Jardim RN, Gonzales NS, Pereira JS, Fais VC, Gonzales Junior FL. Occult hepatitis B virus infection in immunocompromised patients. Braz J Infect Dis 2008, 12:300-305.
8. Kusumoto S, Tanaka Y, Mizokami M, Ueda R. Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma. Int J STD AIDS 2009, 20:336-338. 10.1258/ijsa.2008.008377, 19386971.
9. Bellini C, Keiser O, Chave JP, Evison J, Fehr J, Kaiser L, Weber R, Vernazza P, Bernasconi E, Telenti A, Cavassini M, . Swiss HIV Cohort Study Liver enzyme elevation after lamivudine withdrawal in HIV-hepatitis B virus co-infected patients: the Swiss HIV Cohort Study. HIV Med 2009, 10:12-18. 10.1111/j.1468-1293.2008.00646.x, 18795964, Swiss HIV Cohort Study.
10. Chamorro AJ, Casado JL, Bellido D, Moreno S. Reactivation of hepatitis B in an HIV-infected patient with antibodies against hepatitis B core antigen as the only serological marker. Eur J Clin Microbiol Infect Dis 2005, 24:492-494. 10.1007/s10096-005-1355-1, 15990987.
11. Clark SJ, Creighton S, Horner M, Smith HM, Portmann B, Taylor C, Cramp ME. Reactivation of latent hepatitis B virus infection with HIV-related immunosuppression. Int J Int J STD AIDS 2006, 17:67-69.
12. Bagaglio S, Porrino L, Lazzarin A, Morsica G. Molecular characterization of occult and overt hepatitis B (HBV) infection in an HIV-infected person with reactivation of HBV after antiretroviral treatment interruption. Infection 2010, 38:417-421. 10.1007/s15010-010-0032-1, 20533073.
13. Soriano V, Vispo E, Bottecchia M, Sheldon J, Tuma P, Garcia-Samaniego J, Barreiro P. Management of hepatitis B virus co-infection on and off antiretroviral therapy. Curr HIV/AIDS Rep 2008, 5:86-93. 10.1007/s11904-008-0014-4, 18510894.
14. Martín-Carbonero L, Teixeira T, Poveda E, Plaza Z, Vispo E, González-Lahoz J, Soriano V. Clinical and virological outcomes in HIV-infected patients with chronic hepatitis B on long-term nucleos(t)ide analogues. AIDS 2011, 25:73-79. 10.1097/QAD.0b013e328340fde2, 21076274.
15. Bhattacharya S, Ijaz S, Ratnaraja N, Smith S, Osmana H, Boxall E. Hepatitis B virus reactivation in a large haemodialysis unit: Virological and infection control issues. J Clin Virol 2009, 46:101-103. 10.1016/j.jcv.2009.05.037, 19560397.
16. Bani-Sadr F, Maillard A, Ponscarme D, Scieux C, Molina JM. Reactivation of HBV replication in HIV-HBV infected patients. Am J Med 2003, 114:768-769.
17. Yuki N, Nagaoka T, Yamashiro M, Mochizuki K, Kaneko A, Yamamoto K, Omura M, Hikiji K, Kato M. Long-term histologic and virologic outcomes of acute self-limited hepatitis B. Hepatology 2003, 37:1172-1179. 10.1053/jhep.2003.50171, 12717399.
18. Blackberg J, Kidd-Ljunggren K. Occult hepatitis B virus after acute selflimited infection persisting for 30 years without sequence variation. J Hepatol 2000, 33:992-997. 10.1016/S0168-8278(00)80134-8, 11131464.
19. Locarnini S. Hepatitis B viral resistance: mechanisms and diagnosis. J Hepatol 2003, 39(suppl):124-132.
20. Coleman PF. Detecting hepatitis B surface antigen mutants. EID 2006, 12:198-203.
21. Bock CT, Tillmann HL, Torresi J, Klempnauer J, Locarnini S, Manns MP, Trautwein C. Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplantation. Gastroenterol 2002, 122:264-273.
22. Pondé RA. The underlying mechanisms for the "simultaneous HBsAg and anti-HBs serological profile". Eur J Microbiol Infect Dis 2011,
23. Cohen Stuart JV, Velema M, Schuurman R, Boucher CA, Hoepelman AI. Occult hepatitis B in persons infected with HIV is associated with low CD4 counts and resolves during antiretroviral therapy. J Med Virol 2009, 8:441-445.
24. Tsui JI, Frennch AL, Seaberg EC, Augenbraun M, Nowicki M, Peters M, Tien PC. Prevalence and long-term effects of occult hepatitis B virus infection in HIV-infected women. Clin Infect Dis 2007, 45:736-740. 10.1086/520989, 17712758.
25. Zerbini A, Pilli M, Boni C, Fisicaro P, Penna A, Di Vincenzo P, Giuberti T, Orlandini A, Raffa G, Pollicino T, Raimondo G, Ferrari C, Missale G. The characteristics of the cell-mediated immune response identify different profiles of occult hepatitis B virus infection. Gastroenterol 2008, 134:1470-1481.
26. Stuyver LJ, Locarnini SA, Lok A, Richman DD, Carman WF, Dienstag JL, Schinazi RF. Nomenclature for antiviral-resistant hepatitis B virus mutations inthe polymerase region. Hepatology 2001, 33:751-757. 10.1053/jhep.2001.22166, 11230757.