Intravital microscopy of the mouse brain microcirculation using a closed cranial window

Journal of Visualized Experiments

Volumn , Issue 45, 2010, Pages

  Cabrales, Pedro ^a   Carvalho, Leonardo J M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LA JOLLA BIOENGINEERING INSTITUTE   (United States)

Author keywords

Blood flow; Brain hemodynamics; Cerebral malaria; Issue 45; Leukocyte adherence; Microcirculation; Neuroscience; Vascular morphology

Indexed keywords

EID: 80355124169     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/2184     Document Type: Article

References (6)

1. Mostany, R., & Portera-Cailliau, C. A craniotomy surgery procedure for chronic brain imaging. J. Vis. Exp. 15: 680 (2008).
2. Intaglietta M. & Tompkins W.R. Microvascular measurements by video image shearing and splitting. Microvasc. Res. 5:309-312 (1973).
3. Briceno, J.C., Cabrales, P., Tsai, A.G., Intaglietta M. Radial displacement of red blood cells during hemodilution and the effect on arteriolar oxygen profile. Am. J. Physiol. Heart Circ. Physiol. 286: H1223-1228 (2004).
4. Bishop, J.J., Nance, P.R., Popel, A.S., Intaglietta, M., Johnson, P.C. Relationship between erythrocyte aggregate size and flow rate in skeletal muscle venules. Am. J. Physiol. Heart Circ. Physiol. 286: H113-120 (2004).
5. Baldwin, A.L. Modified hemoglobins produce venular interendothelial gaps and albumin leakage in the rat mesentery. Am. J. Physiol. Heart Circ. Physiol. 277: H650-H659 (1999).
6. Cabrales, P., Zanini, G.M., Meays, D., Frangos, J.A., Carvalho, L.J. Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. Am. J. Pathol. 176(3):1306-1315 (2010).