Effect of partial and complete blockade of vanilloid (TRPV1-6) and ankyrin (TRPA1) transient receptor potential ion channels on urinary bladder motor activity in an experimental hyperosmolar overactive bladder rat model

Journal of Physiology and Pharmacology

Volumn 62, Issue 3, 2011, Pages 321-326

  Juszczak, Kajetan ^a,b   Ziomber, A ^a   Thor, P J ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b Rydygier Memorial Hospital   (Poland)

Author keywords

Capsaicin; Detrusor overactivity; Hyperosmolarity; Ruthenium red; Transient receptor potential ankyrin; Transient receptor potential vanilloid type 1

Indexed keywords

CAPSAICIN; RUTHENIUM RED; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER; BLADDER CONTRACTION; BLADDER DISTENSION; BLADDER FUNCTION; BLADDER MUSCLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FEMALE; HYPEROSMOLARITY; MICTURITION; MOTOR ACTIVITY; NONHUMAN; OVERACTIVE BLADDER; PROTEIN FUNCTION; RAT; RECEPTOR BLOCKING; STIMULUS RESPONSE; URINE FLOW RATE; URINE RETENTION;

ADMINISTRATION, INTRAVESICAL; ANIMALS; ANKYRINS; CAPSAICIN; DISEASE MODELS, ANIMAL; FEMALE; OSMOLAR CONCENTRATION; RANDOM ALLOCATION; RATS; RATS, WISTAR; RUTHENIUM RED; SALINE SOLUTION, HYPERTONIC; TRPC CATION CHANNELS; TRPV CATION CHANNELS; URINARY BLADDER; URINARY BLADDER, OVERACTIVE; URINARY RETENTION;

EID: 80355123806     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Juszczak K, Wyczolkowski M, Thor PJ. The participation of afferent C-fibres in micturition reflex regulation. Adv Clin Exp Med 2010; 19: 13-19.
2. Yokoyama O. Pharmacological and genetic analysis of mechanisms underlying detrusor overactivity in rats. Neurourol Urodyn 2010; 29: 107-11.
3. Pannek J, Stohrer M, Blok B, et al. Guidelines on Neurogenic Lower Urinary Tract Dysfunction. European Association of Urology Guidelines 2011 (Update March 2011), pp 1-64.
4. Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999; 51: 159-212.
5. Andrade EL, Ferreira J, Andre E, Calixto JB. Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder. Biochem Pharmacol 2006; 72: 104-114.
6. Streng T, Axelsson HE, Hedlund P, et al. Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol 2008; 53: 391-399.
7. Birder LA, Kanai AJ, de Groat WC, et al. Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. PNAS 2001; 98: 13396-13401.
8. Chuang YC, Chancellor MB, Seki S, et al. Intravesical protamine sulfate and potassium chloride as a model for bladder hyperactivity. Urology 2003; 61: 664-670.
9. Garland A, Jordan JE, Necheles J, et al. Hypertonicity, but not hypothermia, elicits substance P release from rat C-fiber neurons in primary culture. J Clin Invest 1995; 95: 2359-2366.
10. Zhang HF, Chen J, Faltynek CR, Moreland RB, Neelands TR. Transient receptor potential A1 mediates an osmotically activated ion channel. Eur J Neurosci 2008; 27: 605-611.
11. Dinis P, Churrua A, Avelino A, Cruz F. Intravesical resiniferatoxin decreases spinal c-fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders. BJU Int 2004; 94: 153-157.
12. Kulick LJ, Clemons DJ, Hall R, Koch MA. Refinement of the urine concentration test in rats. Contemp Top Lab Anim Sci 2005; 44: 46-49.
13. Juszczak K, Ziomber A, Wyczołkowski M, Thor PJ. Hyperosmolarity alters the micturition: the comparison of urinary bladder motor activity in hyperosmolar and cyclophosphamide-induced models of overactive bladder. Can J Physiol Pharmacol 2010; 8: 899-906.
14. Komiyama I, Igawa Y, Ishizuka O, Nishizawa O, Andersson KE. Effect of intravesical capsaicin and resiniferatoxin on distension-induced bladder contraction in conscious rats with and without chronic spinal cord injury. J Urol 1999; 161: 314-319.
15. Juszczak K, Ziomber A, Wyczołkowski M, Thor PJ. Urodynamic effects of the bladder C-fiber afferent activity modulation in chronic overactive bladder model rats. J Physiol Pharmacol 2009; 60: 85-91.
16. Juszczak K, Krolczyk G, Filipek M, Dobrowolski ZF, Thor PJ. Animal models of overactive bladder: cyclophosphamide (CYP)-induced cystitis in rats. Folia Med Cracov 2007; 48: 113-123.
17. Elstad EA, Maserejian NN, McKinlay JB, Tennstedt SL. Fluid manipulation among individuals with lower urinary tract symptoms: a mixed methods study. J Clin Nurs 2011; 20: 156-165.
18. Hashim H, Al Mousa R. Management of fluid intake in patients with overactive bladder. Curr Urol Rep 2009; 10: 428-433.
19. Tramontana M, Ceconi R, Del Bianco E, et al. Hypertonic media produce Ca(2+)-dependent release of calcitonin generelated peptide from capsaicin-sensitive nerve fibres in the rat urinary bladder. Neurosci Lett 1991; 124: 79-82.
20. Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol Rev 2007; 87: 165-217.
21. Avelino A, Cruz C, Nagy I, Cruz F. Vanilloid receptor 1 expression in the rat urinary tract. Neuroscience 2002; 109: 787-798.
22. Geppetti P, Nassini R, Materazzi S, Benemei S. The concept of neurogenic inflammation. BJU Int 2008; 101: 2-6.
23. De Groat WC. The urothelium in overactive bladder: passive bystander or active participant? Urology 2004; 64(6A): 7-11.
24. Juszczak K, Gil K, Wyczolkowski M, Thor PJ. Functional, histological and mastocytes alterations in rat urinary bladders following acute and chronic cyclophosphamide treatment. J Physiol Pharmacol 2010; 61: 477-482.
25. Bossowska A, Crayton R, Radziszewski P, Kmiec Z, Majewski M. Distribution and neurochemical characterization of sensory dorsal root ganglia neurons supplying porcine urinary bladder. J Physiol Pharmacol 2009; 60(Suppl 4): 77-81.
26. Martin-Cano FE, Gomez-Pinilla PJ, Pozo MJ, Camello PJ. Spontaneous calcium oscillations in urinary bladder smooth muscle cells. J Physiol Pharmacol 2009; 60(4): 93-99.
27. Del Bianco E, Tramontana M, Bertrand C, Geppetti P. Release of sensory CGRP by hypertonic NaCl is not blocked by tetrodotoxin, omega-conotoxin, nifedipine and ruthenium red. Life Sci 1992; 51: 73-76.
28. Komiyama I, Igawa Y, Ishizuka O, Nishizawa O, Andersson KE. Effect of intravesical capsaicin and resiniferatoxinon distension-induced bladder contraction in conscious rats with and without chronic spinal cord injury. J Urol 1999; 161: 314-319.