Gastrointestinal toxicity due to bitter bottle gourd (Lagenaria siceraria){box drawings light horizontal}a report of 15 cases

Indian Journal of Gastroenterology

Volumn 30, Issue 5, 2011, Pages 233-236

  Puri, Rajesh ^a   Sud, Randhir ^a   Khaliq, Abdul ^b   Kumar, Mandhir ^c   Jain, Sanjay ^c  

^a Medanta the Medicity ^*  (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^c SIR GANGA RAM HOSPITAL   (India)

Author keywords

Bottle gourd; Complementary and alternative medicine; Endoscopy; Erosions; Hematemesis

Indexed keywords

CRYSTALLOID AGENT; GASTROINTESTINAL AGENT; INOTROPIC AGENT; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; AGED; ALTERNATIVE MEDICINE; ARTICLE; CLINICAL ARTICLE; CLINICAL EXAMINATION; CLINICAL FEATURE; CONSERVATIVE TREATMENT; DIARRHEA; ENDOSCOPY; ESOPHAGITIS; FEMALE; GASTROINTESTINAL TOXICITY; HEMATEMESIS; HUMAN; HYPOTENSION; INTENSIVE CARE UNIT; LAGENARIA SICERARIA; MALE; OBSERVATIONAL STUDY; VOMITING;

ABDOMINAL PAIN; ADULT; AGED; CUCURBITACEAE; FEMALE; GASTROINTESTINAL DISEASES; GASTROINTESTINAL HEMORRHAGE; HEMATEMESIS; HUMANS; HYPOTENSION; ISOTONIC SOLUTIONS; MALE; MIDDLE AGED; PLANT EXTRACTS; PROTON PUMP INHIBITORS; VOMITING;

EID: 80255135544     PISSN: 02548860     EISSN: 09750711     Source Type: Journal    
DOI: 10.1007/s12664-011-0110-z     Document Type: Article

References (18)

1. Ghule BV, Ghanti MH, Saoji AN, Yeole PG. Antihyperlipidemic effects of metabolite extract from Lagenaria siceraria stand. Fruit in hyperlipidemic rats. J Ethnopharmacol. 2009; 124: 333-7.
2. Ghule BV, Ghanti MH, Yeole PG, Saoji AN. Diuretic activity of Lagenaria siceraria fruit extracts in rats. Indian J Pharm Sci. 2007; 69: 817-9.
3. Deshpande JR, Choudary AA, Mishra MR, Meghre VS, Wadodkar SG, Dorle AK. Beneficial effects of Lagenaria siceraria (Mol.) stand. Fruit epicarp in animal models. Indian J Exp Biol. 2008; 46: 234-42.
4. Duke JA. Handbook of Phytochemical Constituents of GRAS Herbs and other Economic Plants 1992. Boca Raton: CRC; 1989. p. 315-6.
5. Miro M. Cucurbitacins and their pharmacological effects. Phytother Res. 1995; 9: 159-68.
6. Witkowski A, Knopa J. Binding of the cytotoxic and antitumor triterpenes, cucurbitacins, to glucocorticoid receptors of He La cells. Biochim Biophys Acta. 1981; 674: 246-55.
7. Edery H, Schatzberg PG, Gitter S. Pharmacodynamic activity of elaterician (cucurbitacin D). Arch Int Pharmacodyn. 1961; 130: 315-35.
8. Lee DH, Iwanski GB, Thoenniseen NH. Cucurbitacin: ancient compound shedding new light on cancer treatment. Scientific World J. 2010; 10: 413-8.
9. Browning S, Hodges L. Cucumber crop information: bitterness in zucchini squash and cucumber. University of Nebraska Lincoln, NE 68583. Newsletter, August 2004.
10. Ferguson JE, Fischer DC, Metcalf RL. A report of cucurbitacins poisoning in humans. Cucurbit Genetics Cooperative Report. 1983; 6: 73-4. http://cuke. hort. ncsu. edu/cgc/cgc06/cgc6-37. html. Accessed 15 April 2011.
11. Rymal KS, Chambliss OL, Bond MD, Smith DA. Squash containing toxic cucurbitacin compounds occurring in California and Alabama. J Food Prot. 1984; 47: 270-1.
12. Aldous JC, Ellam GA, Murray V, Pike G. An outbreak of illness among school children in London: toxic poisoning not mass hysteria. J Epidemiol Commun Health. 1994; 48: 45-6.
13. Goldfain D, Lavergne A, Galian A, Chauvenic L, Prudhomme F. Peculiar acute toxic colitis after ingestion of colocynth: a clinicopathological study of three cases. Gut. 1989; 30: 1412-8.
14. Khan SA, Shelleh HH, Bhat AR, Bhat KS. Colocynth toxicity. A possible cause of bloody diarrhea. Saudi Med J. 2003; 24: 904-6.
15. Nadkarni N, D'Cruz S, Sachdev A. Hemetemesis due to bitter melon (Momordica charantia) extract-induced gastric ulcerations. Indian J Gastroenterol. 2010; 29: 37-9.
16. Sharma A, Sharma JP, Jindal R, Kaushik RM. Bottle gourd poisoning. J K Sci. 2006; 8: 120-1.
17. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981; 30: 239-45.
18. Edwards IR, Blriell C. Harmonisation in pharmaco vigilance. Drug Saf. 1994; 10: 93-102.