Severity of coronary artery disease in postmenopausal women: Association with the androgen receptor gene (CAG) n repeat polymorphism

Menopause

Volumn 18, Issue 11, 2011, Pages 1225-1231

  Saltiki, Katerina ^a   Cimponeriu, Adriana ^a   Garofalaki, Maria ^b   Sarika, Lida ^a   Papathoma, Alexandra ^a   Stamatelopoulos, Kimon ^a   Alevizaki, Maria ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b EVANGELISMOS HOSPITAL   (Greece)

Author keywords

Androgen; Androgen receptor gene polymorphism; Atherosclerosis; Cardiovascular; Menopause

Indexed keywords

ANDROGEN RECEPTOR; ANTILIPEMIC AGENT; BIOLOGICAL MARKER; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; SEX HORMONE BINDING GLOBULIN;

ADULT; AGED; ANGINA PECTORIS; ANGIOCARDIOGRAPHY; ARTICLE; CAG REPEAT; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY DISEASE; DISEASE SEVERITY; FEMALE; GENETIC POLYMORPHISM; HEART INFARCTION; HUMAN; LONG TERMINAL REPEAT; MAJOR CLINICAL STUDY; POSTMENOPAUSE; SHORT TANDEM REPEAT; STENOSIS; TRANSCRIPTION REGULATION;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CORONARY ARTERY DISEASE; FEMALE; GENOTYPE; GENOTYPING TECHNIQUES; HUMANS; MIDDLE AGED; PEPTIDES; POLYMORPHISM, GENETIC; POSTMENOPAUSE; RECEPTORS, ANDROGEN; REGRESSION ANALYSIS; SEVERITY OF ILLNESS INDEX; TANDEM REPEAT SEQUENCES;

EID: 80255132737     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/gme.0b013e31821b81b8     Document Type: Article

References (41)

1. Isles CG, Hole DJ, Hawthorne VM, Lever AF. Relation between coronary risk and coronary mortality in women of the Renfrew and Paisley survey: comparison with men. Lancet 1992;339:702-706.
2. Saltiki K, Alevizaki M. Coronary heart disease in postmenopausal women: the role of endogenous estrogens and their receptors. Hormones (Athens) 2007;6:9-24.
3. McCredie RJ, McCrohon JA, Turner L, Griffiths KA, Handelsman DJ, Celermajer DS. Vascular reactivity is impaired in genetic females taking high-dose androgens. J Am Coll Cardiol 1998;32:1331-1335.
4. Sullivan ML, Martinez CM, Gennis P, Gallagher EJ. The cardiac toxicity of anabolic steroids. Prog Cardiovasc Dis 1998;41:1-15. (Pubitemid 28385246)
5. Patel SM, Ratcliffe SJ, Reilly MP, et al. Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2009;94: 4776-4784.
6. Maturana MA, Breda V, Lhullier F, Spritzer PM. Relationship between endogenous testosterone and cardiovascular risk in early postmenopausal women. Metabolism 2008;57:961-965. (Pubitemid 351814689)
7. Wu FC, von Eckardstein A. Androgens and coronary artery disease. Endocr Rev 2003;24:183-217. (Pubitemid 36515284)
8. Alevizaki M, Saltiki K, Xita N, et al. The importance of the (TAAAA)n alleles at the SHBG gene promoter for the severity of coronary artery disease in postmenopausal women. Menopause 2008;15:461-468. (Pubitemid 351656750)
9. Khosla S. Sex hormone binding globulin: inhibitor or facilitator (or both) of sex steroid action? [editorial] J Clin Endocrinol Metab 2006;91: 4764-4766. (Pubitemid 44917303)
10. Rajender S, Singh L, Thangaraj K. Phenotypic heterogeneity of mutations in androgen receptor gene. Asian J Androl 2007;9:147-179. (Pubitemid 46416577)
11. Chamberlain NL, Driver ED, Miesfeld RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 1994;22:3181-3186. (Pubitemid 24260654)
12. Beilin J, Ball EM, Favaloro JM, Zajac JD. Effect of the androgen receptor CAG repeat polymorphism on transcriptional activity: specificity in prostate and non-prostate cell lines. J Mol Endocrinol 2000;25: 85-96. (Pubitemid 30617076)
13. von Eckardstein S, Syska A, Gromoll J, Kamischke A, Simoni M, Nieschlag E. Inverse correlation between sperm concentration and number of androgen receptor CAG repeats in normal men. J Clin Endocrinol Metab 2001;86:2585-2590. (Pubitemid 32545710)
14. Shah NA, Antoine HJ, Pall M, Taylor KD, Azziz R, Goodarzi MO. Association of androgen receptor CAG repeat polymorphism and polycystic ovary syndrome. J Clin Endocrinol Metab 2008;93:1939-1945. (Pubitemid 351656541)
15. Jaaskelainen J, Korhonen S, Voutilainen R, Hippelainen M, Heinonen S. Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome. Fertil Steril 2005;83:1724-1728. (Pubitemid 40824805)
16. Lappalainen S, Utriainen P, Kuulasmaa T, Voutilainen R, Jaaskelainen J. Androgen receptor gene CAG repeat polymorphism and X-chromosome inactivation in children with premature adrenarche. J Clin Endocrinol Metab 2008;93:1304-1309. (Pubitemid 351519725)
17. Vottero A, Capelletti M, Giuliodori S, et al. Decreased androgen receptor gene methylation in premature pubarche: a novel pathogenetic mechanism? J Clin Endocrinol Metab 2006;91:968-972. (Pubitemid 43357767)
18. Ibanez L, Ong KK, Mongan N, et al. Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism. J Clin Endocrinol Metab 2003;88:3333-3338. (Pubitemid 36877513)
19. Zitzmann M, Brune M, Kornmann B, et al. The CAG repeat polymorphism in the AR gene affects high density lipoprotein cholesterol and arterial vasoreactivity. J Clin Endocrinol Metab 2001;86:4867-4873. (Pubitemid 33020534)
20. Hersberger M, Muntwyler J, Funke H, et al. The CAG repeat polymorphism in the androgen receptor gene is associated with HDLcholesterol but not with coronary atherosclerosis or myocardial infarction. Clin Chem 2005;51:1110-1115. (Pubitemid 43079386)
21. Alevizaki M, Cimponeriu AT, Garofallaki M, et al. The androgen receptor gene CAG polymorphism is associated with the severity of coronary artery disease in men. Clin Endocrinol (Oxf ) 2003;59:749-755. (Pubitemid 37491579)
22. Rexrode KM, Ridker PM, Hegener HH, Buring JE, Manson JE, Zee RY. Genetic variation of the androgen receptor and risk of myocardial infarction and ischemic stroke in women. Stroke 2008;39:1590-1592.
23. Saltiki K, Cimponeriu A, Lili K, Peppa M, Anastasiou E, Alevizaki M. Severity of coronary artery disease in postmenopausal diabetic women. Hormones (Athens) 2008;7:148-155.
24. Calvo RM, Asuncion M, Sancho J, San Millan JL, Escobar-Morreale HF. The role of the CAG repeat polymorphism in the androgen receptor gene and of skewed X-chromosome inactivation, in the pathogenesis of hirsutism. J Clin Endocrinol Metab 2000;85:1735-1740. (Pubitemid 32289527)
25. Page ST, Kupelian V, Bremner WJ, McKinlay JB. The androgen receptor gene CAG repeat polymorphism does not predict increased risk of heart disease: longitudinal results from the Massachusetts Male Ageing Study. Clin Endocrinol (Oxf ) 2006;65:333-339.
26. Xita N, Georgiou I, Lazaros L, Psofaki V, Kolios G, Tsatsoulis A. The role of sex hormone-binding globulin and androgen receptor gene variants in the development of polycystic ovary syndrome. Hum Reprod 2008;23:693-698. (Pubitemid 351651201)
27. Xita N, Tsatsoulis A. Review: Fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies. J Clin Endocrinol Metab 2006;91:1660-1666.
28. Westberg L, Baghaei F, Rosmond R, et al. Polymorphisms of the androgen receptor gene and the estrogen receptor A gene are associated with androgen levels in women. J Clin Endocrinol Metab 2001;86: 2562-2568. (Pubitemid 32545707)
29. Vottero A, Stratakis CA, Ghizzoni L, Longui CA, Karl M, Chrousos GP. Androgen receptor-mediated hypersensitivity to androgens in women with nonhyperandrogenic hirsutism: skewing of X-chromosome inactivation. J Clin Endocrinol Metab 1999;84:1091-1095. (Pubitemid 29138248)
30. Sun BK, Tsao H. X-chromosome inactivation and skin disease. J Invest Dermatol 2008;128:2753-2759.
31. Carrel L, Willard HF. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 2005;434:400-404. (Pubitemid 40469185)
32. Brum IS, Spritzer PM, Paris F, Maturana MA, Audran F, Sultan C. Association between androgen receptor gene CAG repeat polymorphism and plasma testosterone levels in postmenopausal women. J Soc Gynecol Investig 2005;12:135-141. (Pubitemid 40202850)
33. Jaaskelainen J, Korhonen S, Kuulasmaa T, et al. Androgen receptor gene CAG repeat length in women with metabolic syndrome. Gynecol Endocrinol 2008;24:411-416. (Pubitemid 352032235)
34. Reinecke H, Bogdanski J, Woltering A, et al. Relation of serum levels of sex hormone binding globulin to coronary heart disease in postmenopausal women. Am J Cardiol 2002;90:364-368.
35. Bell RJ, Davison SL, Papalia MA, McKenzie DP, Davis SR. Endogenous androgen levels and cardiovascular risk profile in women across the adult life span. Menopause 2007;14:630-638. (Pubitemid 47051955)
36. Rodriguez-Gonzalez G, Ramirez-Moreno R, Perez P, et al. The GGN and CAG repeat polymorphisms in the exon-1 of the androgen receptor gene are, respectively, associated with insulin resistance in men and with dyslipidemia in women. J Steroid Biochem Mol Biol 2009;113:202-208.
37. Liu Q, Hong J, Cui B, et al. Androgen receptor gene CAG(n) trinucleotide repeats polymorphism in Chinese women with polycystic ovary syndrome. Endocrine 2008;33:165-170.
38. Zitzmann M, Gromoll J, von Eckardstein A, Nieschlag E. The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men. Diabetologia 2003;46:31-39. (Pubitemid 36237744)
39. Skjaerpe PA, Giwercman YL, Giwercman A, Svartberg J. Androgen receptor gene polymorphism and the metabolic syndrome in 60-80 years old Norwegian men. Int J Androl 2010;33:500-506.
40. Gustafson DR, Wen MJ, Koppanati BM. Androgen receptor gene repeats and indices of obesity in older adults. Int J Obes Relat Metab Disord 2003;27:75-81. (Pubitemid 36152783)
41. Bhasin S, Woodhouse L, Casaburi R, et al. Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab 2001;281:E1172-E1181.