Discrimination between COPD patients with and without alpha 1-antitrypsin deficiency using an electronic nose

Respirology

Volumn 16, Issue 8, 2011, Pages 1258-1264

  Hattesohl, Akira D M ^a   Jörres, Rudolf A ^b   Dressel, Holger ^b   Schmid, Severin ^a   Vogelmeier, Claus ^a   Greulich, Timm ^a   Noeske, Sarah ^a   Bals, Robert ^c   Koczulla, Andreas Rembert ^a  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

alpha 1 antitrypsin deficiency; chronic obstructive pulmonary disease; electronic nose; exhaled breath; volatile organic compound

Indexed keywords

ALPHA 1 ANTITRYPSIN; VOLATILE ORGANIC COMPOUND;

ADULT; AGED; ALPHA 1 ANTITRYPSIN DEFICIENCY; ANALYZER; ARTICLE; BREATH ANALYSIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRONIC NOSE ANALYZER; EXPIRED AIR; FEMALE; HUMAN; MALE; ODOR; PATIENT IDENTIFICATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ALPHA 1-ANTITRYPSIN DEFICIENCY; BIOSENSING TECHNIQUES; BREATH TESTS; CASE-CONTROL STUDIES; DIAGNOSIS, DIFFERENTIAL; DISCRIMINANT ANALYSIS; EXHALATION; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; QUESTIONNAIRES; SENSITIVITY AND SPECIFICITY; VOLATILE ORGANIC COMPOUNDS;

EID: 80155202775     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2011.02047.x     Document Type: Article

References (31)

1. Rabe KF, Hurd S, Anzueto A, et al,. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am. J. Respir. Crit. Care Med. 2007; 176: 532-55. (Pubitemid 47403272)
2. Bals R, Koczulla R, Kotke V, et al,. Identification of individuals with alpha-1-antitrypsin deficiency by a targeted screening program. Respir. Med. 2007; 101: 1708-14. (Pubitemid 46947877)
3. Fens N, Zwinderman AH, van der Schee MP, et al,. Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am. J. Respir. Crit. Care Med. 2009; 180: 1076-82.
4. Moser B, Bodrogi F, Eibl G, et al,. Mass spectrometric profile of exhaled breath-field study by PTR-MS. Respir. Physiol. Neurobiol. 2005; 145: 295-300. (Pubitemid 40215660)
5. Lewis NS,. Comparisons between mammalian and artificial olfaction based on arrays of carbon black-polymer composite vapor detectors. Acc. Chem. Res. 2004; 37: 663-72.
6. Thaler ER, Hanson CW,. Medical applications of electronic nose technology. Expert Rev. Med. Devices 2005; 2: 559-66. (Pubitemid 41447653)
7. Dragonieri S, Annema JT, Schot R, et al,. An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD. Lung Cancer 2009; 64: 166-70.
8. Holme J, Stockley RA,. Radiologic and clinical features of COPD patients with discordant pulmonary physiology: lessons from alpha1-antitrypsin deficiency. Chest 2007; 132: 909-15.
9. Baumbach JI,. Ion mobility spectrometry coupled with multi-capillary columns for metabolic profiling of human breath. J. Breath. Res. 2009; 3: 034001.
10. Lai SY, Deffenderfer OF, Hanson W, et al,. Identification of upper respiratory bacterial pathogens with the electronic nose. Laryngoscope 2002; 112: 975-9. (Pubitemid 34615050)
11. Dutta R, Hines EL, Gardner JW, et al,. Bacteria classification using Cyranose 320 electronic nose. Biomed. Eng. Online 2002; 1: 4.
12. Shykhon ME, Morgan DW, Dutta R, et al,. Clinical evaluation of the electronic nose in the diagnosis of ear, nose and throat infection: a preliminary study. J. Laryngol. Otol. 2004; 118: 706-9. (Pubitemid 39424744)
13. Hockstein NG, Thaler ER, Torigian D, et al,. Diagnosis of pneumonia with an electronic nose: correlation of vapor signature with chest computed tomography scan findings. Laryngoscope 2004; 114: 1701-5. (Pubitemid 39332240)
14. Machado RF, Laskowski D, Deffenderfer O, et al,. Detection of lung cancer by sensor array analyses of exhaled breath. Am. J. Respir. Crit. Care Med. 2005; 171: 1286-91. (Pubitemid 40740737)
15. D'Amico A, Pennazza G, Santonico M, et al,. An investigation on electronic nose diagnosis of lung cancer. Lung Cancer 2010; 68: 170-6.
16. Dragonieri S, Schot R, Mertens BJ, et al,. An electronic nose in the discrimination of patients with asthma and controls. J. Allergy Clin. Immunol. 2007; 120: 856-62. (Pubitemid 47542280)
17. Barnes PJ,. The cytokine network in asthma and chronic obstructive pulmonary disease. J. Clin. Invest. 2008; 118: 3546-56.
18. Malerba M, Ragnoli B, Radaeli A,. Exhaled nitric oxide levels in alpha-1-antitrypsin PiMZ subjects. J. Intern. Med. 2009; 265: 382-7.
19. Machado RF, Stoller JK, Laskowski D, et al,. Low levels of nitric oxide and carbon monoxide in alpha 1-antitrypsin deficiency. J. Appl. Physiol. 2002; 93: 2038-43. (Pubitemid 35379329)
20. Woolhouse IS, Bayley DL, Stockley RA,. Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8. Thorax 2002; 57: 709-14. (Pubitemid 34864528)
21. Montuschi P,. Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications. Ther. Adv. Respir. Dis. 2007; 1: 5-23.
22. Carpagnano GE, Kharitonov SA, Resta O, et al,. Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest 2002; 122: 1162-7. (Pubitemid 35339525)
23. Hoffmeyer F, Raulf-Heimsoth M, Bruning T,. Exhaled breath condensate and airway inflammation. Curr. Opin. Allergy Clin. Immunol. 2009; 9: 16-22.
24. Kharitonov SA, Barnes PJ,. Exhaled markers of inflammation. Curr. Opin. Allergy Clin. Immunol. 2001; 1: 217-24.
25. Montuschi P, Barnes PJ,. Exhaled leukotrienes and prostaglandins in asthma. J. Allergy Clin. Immunol. 2002; 109: 615-20. (Pubitemid 34327186)
26. Montuschi P, Martello S, Felli M, et al,. Liquid chromatography/mass spectrometry analysis of exhaled leukotriene B4 in asthmatic children. Respir. Res. 2005; 6: 119.
27. Effros RM, Biller J, Foss B, et al,. A simple method for estimating respiratory solute dilution in exhaled breath condensates. Am. J. Respir. Crit. Care Med. 2003; 168: 1500-5. (Pubitemid 38037336)
28. Montuschi P, Nightingale JA, Kharitonov SA, et al,. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide. Free Radic. Biol. Med. 2002; 33: 1403-8. (Pubitemid 35284923)
29. Dwyer TM,. Sampling airway surface liquid: non-volatiles in the exhaled breath condensate. Lung 2004; 182: 241-50. (Pubitemid 39315286)
30. Hubbard RC, McElvaney NG, Sellers SE, et al,. A-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency. J. Clin. Invest. 1989; 84: 1349-54. (Pubitemid 19247611)
31. Bossuyt PM, Reitsma JB,. The STARD initiative. Lancet 2003; 361: 71.