Structural characterization of the tobramycin-piperacillin reaction product formed at pH 6.0

Journal of Antibiotics

Volumn 64, Issue 10, 2011, Pages 673-677

  Pagano, Thomas G ^a   Gong, Yumin ^a   Kong, Fangming ^a,b   Tsao, Rushung ^a   Fawzi, Mahdi ^a,c   Zhu, Tianmin ^a  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

^c Warner Chilcott   (United States)

Author keywords

piperacillin; protonation constants; structure elucidation; tobramycin; Y site co administration; Zosyn

Indexed keywords

CITRIC ACID; HYDROCHLORIC ACID; NITROGEN; PIPERACILLIN PLUS TAZOBACTAM; TOBRAMYCIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; DRUG STABILITY; DRUG STRUCTURE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; LIQUID CHROMATOGRAPHY; NITROGEN NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

EID: 80155198751     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2011.72     Document Type: Article

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