Coexistence of blaOXA-48 and aac(6′)-Ib-cr genes in Klebsiella pneumoniae isolates from Istanbul, Turkey

Journal of International Medical Research

Volumn 39, Issue 5, 2011, Pages 1932-1940

  Nazik, H ^a   Ongen B ^a   Mete, B ^a   Aydin, S ^a   Yemisen M ^a   Kelesoglu F M ^b   Ergul, Y ^b   Tabak, F ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Carbapenem Resistance; Carbapenems; Klebsiella Pneumoniae; OXA 48; Plasmids; Quinolone Resistance; Quinolones; Lactamase

Indexed keywords

CARBAPENEM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ANTIINFECTIVE AGENT; BETA LACTAMASE; CARBAPENEM DERIVATIVE; OFLOXACIN;

AAC(6') IB CR GENE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; BETA LACTAMASE CTX M GENE; BETA LACTAMASE OXACILLINASE 48 GENE; BETA LACTAMASE SHV GENE; BETA LACTAMASE TEM GENE; BETA LACTAMASE VEB 1 GENE; CONTROLLED STUDY; GENE; GENE TRANSFER; GROWTH INHIBITION; GROWTH RATE; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; NONHUMAN; POLYMERASE CHAIN REACTION; PULSED FIELD GEL ELECTROPHORESIS; RETROSPECTIVE STUDY; SCREENING TEST; TURKEY (REPUBLIC); DRUG EFFECT; GENETICS; HUMAN; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTION; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; MORTALITY; MULTIDRUG RESISTANCE; PLASMID;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CARBAPENEMS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; GENE TRANSFER TECHNIQUES; GENES, BACTERIAL; GENES, MDR; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; OFLOXACIN; PLASMIDS; TURKEY;

EID: 80155161894     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323001103900538     Document Type: Article

References (31)

1. Aktas E, Yigit N, Yazgi H, et al: Detection of antimicrobial resistance and extendedspectrum a-lactamase production in Klebsiella pneumoniae strains from infected neonates. J Int Med Res 2002; 30: 445-448.
2. Adam D: 2-Lactam/--lactamase inhibitor combinations in empiric management of pediatric infections. J Int Med Res 2002; 30(suppl 1): 10A-19A.
3. Wang Y, Zhang R, Li W, et al: Serious antimicrobial resistance status of pathogens causing hospital-acquired lower respiratory tract infections in North China. J Int Med Res 2009; 37: 899-907.
4. Dajani AS: 4-Lactam resistance: clinical implications for pediatric patients. J Int Med Res 2002; 30(suppl 1): 2A-9A.
5. Walsh T: Emerging carbapenemases: a global perspective. Int J Antimicrob Agents 2010; 36(suppl 3): S8-S14.
6. Queenan AM, Bush K: Carbapenemases: the versatile v-lactamases. Clin Microbiol Rev 2007; 20: 440-458.
7. Poirel L, Heritier C, Tolun V, et al: Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother 2004; 48: 15-22.
8. Cuzon G, Naas T, Bogaerts P, et al: Plasmidencoded carbapenem-hydrolyzing c-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. Antimicrob Agents Chemother 2008; 52: 3463-3464.
9. Carrer A, Poirel L, Yilmaz M, et al: Spread of OXA-48-encoding plasmid in Turkey and beyond. Antimicrob Agents Chemother 2010; 54: 1369-1373.
10. Livermore DM: Has the era of untreatable infections arrived? J Antimicrob Chemother 2009; 64(suppl 1): i29-i36.
11. Robicsek A, Jacoby GA, Hooper DC: The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect Dis 2006; 6: 629-640.
12. Martínez-Martínez L, Pascual A, Jacoby GA: Quinolone resistance from a transferable plasmid. Lancet 1998; 351: 797-799.
13. Yamane K, Wachino J, Suzuki S, et al: New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob Agents Chemother 2007; 51: 3354-3360.
14. Robicsek A, Strahilevitz J, Jacoby GA, et al: Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat Med 2006; 12: 83-88.
15. Nordmann P, Poirel L: Emergence of plasmidmediated resistance to quinolones in Enterobacteriaceae. J Antimicrob Chemother 2005; 56: 463-469.
16. Clinical and Laboratory Standards Institute (CLSI): Performance Standards for Antimicrobial Susceptibility Testing, 19th Informational Supplement, M100-S19. Wayne, PA: CLSI, 2009.
17. Mammeri H, Van De Loo M, Poirel L, et al: Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe. Antimicrob Agents Chemother 2005; 49: 71-76.
18. Nazik H, Ilktaç M, Öngen B: Prevalence of qnrA, qnrB, qnrS and aac(6>)-Ib-cr (in qnr-positive isolates) among the ESBL-positive and/or ciprofloxacin-resistant isolates in Turkey. J Chemother 2009; 21: 219-221.
19. Pallecchi L, Bartoloni A, Fiorelli C, et al: Rapid dissemination and diversity of CTX-M extended-spectrum e-lactamase genes in commensal Escherichia coli isolates from healthy children from low-resource settings in Latin America. Antimicrob Agents Chemother 2007; 51: 2720-2725.
20. Poirel L, Van De Loo M, Mammeri H, et al: Association of plasmid-mediated quinolone resistance with extended-spectrum r-lactamase VEB-1. Antimicrob Agents Chemother 2005; 49: 3091-3094.
21. Cattoir V, Poirel L, Rotimi V, et al: Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates. J Antimicrob Chemother 2007; 60: 394-397.
22. Cavaco LM, Hasman H, Xia S, et al: qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica Serovar Kentucky and Bovismorbificans strains of human origin. Antimicrob Agents Chemother 2009; 53: 603-608.
23. Tenover FC, Arbeit RD, Goering RV, et al: Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995; 33: 2233-2239.
24. Durmaz R, Otlu B, Köksal F, et al: The optimization of a rapid pulsed-field gel electrophoresis protocol for the typing of Acinetobacter baumannii, Escherichia coli and Klebsiella spp. Jpn J Infect Dis 2009; 62: 372-377.
25. Wang M, Sahm DF, Jacoby GA, et al: Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States. Antimicrob Agents Chemother 2004; 48: 1295-1299.
26. Pitout JD: Multiresistant Enterobacteriaceae: new threat of an old problem. Expert Rev Anti Infect Ther 2008; 6: 657-669.
27. Gulmez D, Woodford N, Palepou MF, et al: Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss. Int J Antimicrob Agents 2008; 31: 523-526.
28. Aktaş Z, Kayacan ÇB, Schneider I, et al: Carbapenem-hydrolyzing oxacillinase, OXA-48, persists in Klebsiella pneumoniae in Istanbul, Turkey. Chemotherapy 2008; 54: 101-106.
29. Carrer A, Poirel L, Eraksoy H, et al: Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. Antimicrob Agents Chemother 2008; 52: 2950-2954.
30. Nazik H, Poirel L, Nordmann P: Further identification of plasmid-mediated quinolone resistance determinant in Enterobacteriaceae in Turkey. Antimicrob Agents Chemother 2005; 49: 2146-2147.
31. Martínez-Martínez L, Eliecer Cano M, Manuel Rodríguez-Martínez J, et al: Plasmid-mediated quinolone resistance. Expert Rev Anti Infect Ther 2008; 6: 685-711.