Novel applications of diagnostic X-rays in activating a clinical photodynamic drug: Photofrin II through X-ray induced visible luminescence from "rare-earth" formulated particles

Journal of X-Ray Science and Technology

Volumn 19, Issue 4, 2011, Pages 521-530

  Abliz, Erkinay ^a   Collins, Joshua E ^b   Bell, Howard ^b   Tata, Darrell B ^c  

^a The George Washington University   (United States)

^b Intelligent Material Solutions Inc   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Gadolinium Oxysulfide particles; photodynamic therapy; Photofrin II; reactive oxygen species detection; singlet oxygen; X ray induced luminescence

Indexed keywords

GADOLINIUM OXYSULFIDE PARTICLES; PHOTOFRIN II; REACTIVE OXYGEN SPECIES; SINGLET OXYGEN; X-RAY INDUCED LUMINESCENCE;

CHEMICAL ACTIVATION; DRUG THERAPY; GADOLINIUM; HYDROGEN PEROXIDE; LIGHT; LUMINESCENCE; METABOLISM; NONINVASIVE MEDICAL PROCEDURES; OPTICAL FIBERS; OXYGEN; PHOTODYNAMIC THERAPY; PLASMONS; SURFACE TREATMENT; TERBIUM; TISSUE CULTURE; TUMORS;

X RAYS;

GADOLINIUM; GADOLINIUM SULFOXYLATE; LANTHANIDE; PHOTOFRIN II; PHOTOSENSITIZING AGENT;

CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HUMAN; PHOTOCHEMOTHERAPY; PROCEDURES; RADIATION RESPONSE; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; DIHEMATOPORPHYRIN ETHER; GADOLINIUM; HUMANS; METALS, RARE EARTH; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 80155136165     PISSN: 08953996     EISSN: None     Source Type: Journal    
DOI: 10.3233/XST-2011-0311     Document Type: Article

References (28)

1. B.W. Henderson, Mechanistic Principles of Photodynamic Therapy, Ch 36: Biophotonics Handbook. Ed: Tuan Vo-Dinh. CRC Press, and SPIE Press, 2003.
2. T.J. Dougherty and J.G. Levy, Photodynamic Therapy (PDT) and Clinical applications, Ch 38: Biophotonics Handbook. Ed: Tuan Vo-Dinh. CRC Press, and SPIE Press, 2003.
3. T. Dougherty, C.J. Gomer, B.W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan and Q. Peng, Photodynamic Therapy, JNCI 90 (1998), 889-905.
4. B.W. Henderson and A.C. Miller, Effects of scavengers of reactive oxygen and radical species on cell survival following photodynamic treatment in-vitro: Comparison to ionizing radiation, Rad Res 108 (1986), 196-205.
5. V.V. Tuchin, Light - Tissue interactions, Ch 3 See Fig. 3.1. pp. 3-3: Biophotonics Handbook. Ed: Tuan Vo-Dinh. CRC Press, and SPIE Press, 2003.
6. Y. Nicole, Morgan, Gabriela Kramer-Marek, Paul D. Smith, Kevin Camphausenb and Jacek Capalab, Nanoscintillator Conjugates as Photodynamic Therapy-Based Radiosensitizers: Calculation of Required Physical Parameters. Rad Res 171 (2009), 236-244.
7. X. Wu, A.E. Deans and H. Liu, "X-ray Diagnostic Techniques" Chapter 26 Section 1: Table: 26-1. pp. 26-23: Biophotonics Handbook. Ed: Tuan Vo-Dinh. CRC Press, and SPIE Press, 2003
8. W. Chen and J. Zhang, Using nanoparticles to enable simultaneous radiation and photodynamic therapies for cancer treatment, Nanosci Nanotech 6 (2006), 1159-1166.
9. B. Ungun, R.K. Prud'Homme, S.J. Budijono, J. Shan, S.F. Lim, Y. Ju and R. Austin, Nanofabricated upconversion nanoparticles for photodynamic therapy, Optics Express 5(17) (2009), 80-86.
10. J. Takahashi and M. Misawa, Analysis of potential radiosensitizing materials for X-ray-induced photodynamic therapy, Nanobiotech 3 (2007), 116-126.
11. P. Juzenas, W. Chen, Y.P. Sun, M.A. Coelho, R. Generalov, N. Generalova and I.L. Christensen, Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer, Adv Drug Deliv Rev 60 (2008), 1600-1614.
12. L. Wang, W. Yang, P. Read, J. Larner and K. Sheng, Tumor cell apoptosis induced by nanoparticle conjugate in combination with radiation therapy, Nanotech 21 (2010), 4751031-4751037.
13. J.P. Scaffidi, M.K. Gregas, B. Lauly, Y. Zhang and T. Vo-Dinh, Activity of psoralen-functionalized nano scintillators against cancer cells upon X-ray excitation, ACS Nano. Epub, May, 2011.
14. Y. Liu, W. Chen, S. Wang and A.G. Joly, Investigation of water soluble X-ray Luminescence nanoparticles for Photodynamic therapy, Appl Phys Lett 92 (2008), 043901.
15. D.K. Chatterjee and Z. Yong, Up converting nanoparticles as nanotransducers for photodynamic therapy in cancer cells, Nanomed 3 (2008), 73-82.
16. Fernanda Ricchelli, Photo-physical properties of porphyrins in biological membranes, J Photochem Photobio B: Biol 29 (1995), 109-118.
17. Y. Xiao, S.P. Forry, X. Gao, R.D. Holbrook, W.G. Telford and A. Tona, Dynamics and mechanism of Quantum dot nanoparticles cellular uptake, J Nano Bio Techn 8 (2010), 13-22
18. J.S. Dysart and M.S. Patterson, Characterization of Photofrin photo bleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cells in-vitro, Phys Med Biol 50 (2005), 2597-2615.
19. J. Moan and K. Berg, The photo degradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen, Photochem Photobiol 53 (1991), 549-553.
20. R. Morlotti, M. Nikl, Piazza and C. Borago, Intrinsic conversion efficiency of X-rays to light in Gd2O2S: Tb powder phosphors, J Lumin 72-74 (1997), 772-774.
21. G.E. Giakoumakis, C.D. Nomics, E.N. Yiakoumakis and E.K. Vangelou, Absolute efficiency of rare earth oxysulfide screens in reflection mode observation, Phys Med Bio 35 (1990), 1017-1023.
22. G.E. GiaKoumakis, C.D. Nomicos and P.X. Sandilod, Absolute Efficiency of Gd2O2S: Tb screens under fluoroscopic conditions, Phys Med Biol 34 (1989), 673-678.
23. J. Lindstrom and G.A. Carlsson, A simple model for estimating the particles size dependence of absolute efficiency of fluorescent screens, Phys Med Bio 44 (1999), 1353-1367.
24. C.M. Michail, A. Toutountzis, I.G. Valais, I. Seferis, M. Georgousis, G. Fountos, J.S. Kandarakis and G.S. Panayiotakis, Luminescence Efficiency of Gd2O2S: Eu Powder phosphor as X-ray to Light Convertor, e-Journal of Sci and Tech 2 (2010), 5.
25. J. Beutel, H.L. Kundel and R.L. van Metter, Handbook of Medical Imaging. SPIE Press, Bellingham,WA, USA. Chapter 1 Section 5.3: Conversion efficiency, 2000, p. 70.
26. F.M. Khan, The Physics of Radiation Therapy - 4th ed. LippincottWilliams andWilkins USA. Chapter 3: Production of X-rays Section 3.6: Operating Characteristics, 2010, pp. 33-34.
27. See NIST website on the density of Gadolinium Oxysulfide: Http://physics.nist.gov/cgi-bin/Star/compos.pl?matno=166.
28. See NIST web site on the mass attenuation coefficients as function of X-ray photon energies Table#4: On Gadolinium Oxysulfide and also on brain tissue: Http://physics.nist.gov/PhysRefData/XrayMassCoef/tab4.html.