Antisense inhibition of gene expression and growth in gram-negative bacteria by cell-penetrating peptide conjugates of peptide nucleic acids targeted to rpoD gene

Biomaterials

Volumn 33, Issue 2, 2012, Pages 659-667

  Bai, Hui ^a   You, Yu ^b   Yan, Hua ^a   Meng, Jingru ^a   Xue, Xiaoyan ^a   Hou, Zheng ^a   Zhou, Ying ^a   Ma, Xue ^a   Sang, Guojun ^a   Luo, Xiaoxing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antibiotic resistance; Antisense therapy; Cell penentrating peptide conjugated peptide nucleic acid; Gram negative bacteria; RNA polymerase primary 70

Indexed keywords

ANTI-MICROBIAL ACTIVITY; ANTI-SENSE INHIBITION; ANTIBIOTIC RESISTANCE; ANTISENSE; ANTISENSE THERAPIES; BACTERIAL GROWTH; BASE SEQUENCES; BROAD SPECTRUM; CELL-PENENTRATING PEPTIDE CONJUGATED PEPTIDE NUCLEIC ACID; CELL-PENETRATING PEPTIDE; CLINICAL ISOLATES; CONCENTRATION-DEPENDENT; EPITHELIAL CELLS; GRAM NEGATIVE BACTERIA; HIGH INCIDENCE; HUMAN CELLS; IN-VITRO; INFECTION MODELS; KLEBSIELLA PNEUMONIAE; MULTIDRUG RESISTANCE; PEPTIDE NUCLEIC ACID; REGULATED GENES; RNA POLYMERASE; SALMONELLA ENTERICA; SHIGELLA FLEXNERI; THERAPEUTIC STRATEGY;

ANTIBIOTICS; BACTERIOLOGY; BIOMOLECULES; ESCHERICHIA COLI; GENE EXPRESSION; RNA; SALMONELLA;

PEPTIDES;

BACTERIAL PROTEIN; FTSZ PROTEIN; PEPTIDE NUCLEIC ACID; PRFB PROTEIN; RPOD PROTEIN; SEQA PROTEIN; TURFB PROTEIN; UNCLASSIFIED DRUG; YGJD PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIUM ISOLATE; CELL GROWTH; CELL STRUCTURE; CONJUGATION; CONTROLLED STUDY; DOWN REGULATION; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION; GENE TARGETING; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; KLEBSIELLA PNEUMONIAE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA ENTERICA; SHIGELLA FLEXNERI;

ANTI-BACTERIAL AGENTS; CELL-PENETRATING PEPTIDES; DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; PEPTIDE NUCLEIC ACIDS; RNA, ANTISENSE; RNA, MESSENGER; SALMONELLA ENTERICA; SHIGELLA FLEXNERI; SIGMA FACTOR;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA; SALMONELLA ENTERICA; SHIGELLA FLEXNERI;

EID: 80055121821     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.09.075     Document Type: Article

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