Boron neutron capture therapy induces cell cycle arrest and DNA fragmentation in murine melanoma cells

Applied Radiation and Isotopes

Volumn 69, Issue 12, 2011, Pages 1741-1744

  Faiao Flores F ^a,b   Coelho, P R P ^c   Arruda Neto, J ^b,d   Maria, Durvanei A ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES   (Brazil)

^d FESP   (Brazil)

Author keywords

BNCT; Cell cycle; Cyclin D1; Melanoma; Rhodamine 123

Indexed keywords

BNCT; CELL CYCLE; CYCLIND1; MELANOMA; RHODAMINE 123;

BORON; BORON COMPOUNDS; CELL CULTURE; CELL DEATH; CELL MEMBRANES; DERMATOLOGY; ELECTRIC POTENTIAL; NEUTRONS; PHOSPHORYLATION;

ONCOLOGY;

4 BORONOPHENYLALANINE; CASPASE 3; CYCLIN D1;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MELANOMA; MELANOMA B16; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; NEUTRON CAPTURE THERAPY; NEUTRON RADIATION; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL DESTRUCTION;

ANIMALS; BORON NEUTRON CAPTURE THERAPY; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; DNA FRAGMENTATION; MELANOMA, EXPERIMENTAL; MICE;

EID: 80055087609     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2011.03.005     Document Type: Article

References (11)

1. Barth R.F., Soloway A.H., Fairchild R.G., Brugger R.M. Boron neutron capture therapy for cancer. Realities and prospects. Cancer 1992, 70(12):2995-3007.
2. Bevona C., Sober A.J. Melanoma incidence trends. Dermatol. Clin. 2002, 20(4):589-595.
3. Chen Y., Kramer D.L., Diegelman P., Vujcic S., Porter C.W. Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells. Cancer Res. 2001, 61(17):6437-6444.
4. Coderre J.A., Button T.M., Micca P.L., Fisher C.D., Nawrocky M.M., Liu H.B. Neutron capture therapy of the 9L rat gliosarcoma using the p-boronophenylalanine-fructose complex. Int. J. Radiat. Oncol. Biol. Phys. 1994, 30:643-652.
5. Dagrosa M.A., Crivello M., Thorp S., Perona M., Pozzi E., Casal M., Cabrini R., Kahl S., Juvenal G., Pisarev M. Radiobiological studies in a human cell line of undifferentiated thyroid cancer (UTC) for BNCT. A new option against cancer, Proceedings of 13th International Congress on Neutron Capture Therapy. A new option against cancer, Proceedings of 13th International Congress on Neutron Capture Therapy 2008, 337-340. Florence, Italy, Florence, Italy. A. Zonta, S. Altieri, L. Roveda, R. Barth (Eds.), A. Zonta, S. Altieri, L. Roveda, R. Barth (Eds.).
6. Fuller K.M., Arriaga E.A. Advances in the analysis of single mitochondria. Curr. Opin. Biotechnol. 2003, 14(1):35-41.
7. Kennady P.K., Ormerod M.G., Singh S., Pande G. Variation of mitochondrial size during the cell cycle: a multiparameter flow cytometric and microscopic study. Cytometry A 2004, 62(2):97-108.
8. Li W., Sanki A., Karim R.Z., Thompson J.F., Soon Lee C., Zhuang L., McCarthy S.W., Scolyer R.A. The role of cell cycle regulatory proteins in the pathogenesis of melanoma. Pathology 2006, 38(4):287-301.
9. Mendes P.F., Xander P., Novaes e Brito R.R., Mortara R.A., Jasiulionis M.G., Lopes J.D. A cell surface 230kDa protein from murine melanoma involved with tumor malignancy. Cancer Lett. 2008, 262(2):276-285.
10. Mishima Y., Ichihashi M., Hatta S., Honda C., Yamamura K., Nakagawa T. New thermal neutron capture therapy for malignant melanoma: melanogenesis-seeking 10B molecule-melanoma cell interaction from in vitro to first clinical trial. Pigment Cell Res. 1989, 2(4):226-234.
11. Smalley K.S., Contractor R., Nguyen T.K., Xiao M., Edward R., Muthusamy V., King A.J., Flaherty K.T., Bosenberg M., Herlyn M., Nathanson K.L. Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression. Cancer Res. 2008, 68(14):5743-5752.