Volatile organic compounds as biomarkers of bladder cancer: Sensitivity and specificity using trained sniffer dogs

Cancer Biomarkers

Volumn 8, Issue 3, 2010, Pages 145-153

  Willis, Carolyn M ^a   Britton, Lezlie E ^a   Harris, Rob ^b   Wallace, Joshua ^c   Guest, Claire M ^b  

^a AMERSHAM HOSPITAL   (United Kingdom)

^b Unit 3   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Bladder cancer; canine olfaction; diagnosis; dog; volatile organic compounds

Indexed keywords

BIOLOGICAL MARKER; VOLATILE ORGANIC COMPOUND;

ARTICLE; BLADDER CANCER; CONTROLLED STUDY; DOG; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SMELLING; TRANSITIONAL CELL CARCINOMA; URINALYSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CARCINOMA, TRANSITIONAL CELL; DOGS; FEMALE; HUMANS; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; SMELL; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS; VOLATILE ORGANIC COMPOUNDS;

CANIS FAMILIARIS;

EID: 80055081694     PISSN: 15740153     EISSN: 18758592     Source Type: Journal    
DOI: 10.3233/CBM-2011-0208     Document Type: Article

References (22)

1. J. Ferlay, H. R. Shin, F. Bray, D. Forman, C. Mathers and D. M. Parkin, GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010. Available from: http://globocan. iarc.fr.
2. P. Bassi, V. De Marco, A. De Lisa, M. Mancini, F. Pinto, R. Bertoloni and F. Longo, Non-invasive diagnostic tests for bladder cancer: a review of the literature, Urol Int 75(2005), 193-200.
3. A. S. Glas, D. Roos, M. Deutekom, A. H. Zwinderman, P. M. M. Bossuyt and K. H. Kurth, Tumor markers in the diagnosis of primary bladder cancer: a systematic review, J Urol 169(2003), 1975-1982.
4. A. P. Mitra and R. J. Cote, Molecular screening for bladder cancer: progress and potential, Nat Rev Urol 7(2010), 11-20.
5. C. M. Willis, S. M. Church, C. M. Guest, W. A. Cook, N. McCarthy, A. J. Bransbury, M. R. Church and J. C. Church, Olfactory detection of human bladder cancer by dogs: proof of principle study, BMJ [Br Med J] 329(2004), 712-715.
6. C. M. Willis and N. McCarthy, Smoking is not a confounder of the association between bladder cancer and selection of urine by dogs, BMJ [Br Med J] (Letter) 329(2004), 1286.
7. C. M. Weber, M. Cauchi, M. Patel, C. Bessant, C. Turner, L. E. Britton and C. M. Willis, Evaluation of a gas sensor array and pattern recognition for the identification of bladder cancer from urine headspace, Analyst 136(2011), 359-364.
8. C. Di Natale, A. Macagnano, E. Martinelli, R. Paolesse, G. D'Arcangelo, C. Roscioni, A. Finazzi-Agró and A. D'Amico, Lung cancer identification by the analysis of breath by means of an array of non-selective gas sensors, Biosens Bioelectron 18(2003), 1209-1218.
9. G. Horvath, J. Chilo and T. Lindblad, Different volatile signals emitted by human ovarian carcinoma and healthy tissue, Future Oncol 6(2010), 1043-1049.
10. H. Williams and A. Pembroke, Sniffer dogs in the melanoma clinic? Lancet 1(1989), 734.
11. M. Phillips, K. Gleeson, J. M. Hughes, J. Greenberg, R. N. Cataneo, L. Baker and W. P. McVay, Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study, Lancet 353(1999), 1930-1933.
12. M. McCulloch, T. Jezierski, M. Broffman, A. Hubbard, K. Turner and T. Janecki, Diagnostic accuracy of canine scent detection in early-and late-stage lung and breast cancers, Integ Cancer Ther 5(2006), 30-39.
13. J.-N. Cornu, G. Cancel-Tassin, V. Ondet, C. Girardet and O. Cussenot, Olfactory detection of prostate cancer by dogs sniffing urine: a step forward in early diagnosis, Eur Urol 59(2011), 197-201.
14. H. Sonoda, S. Kohnoe, T. Yamazato, Y. Satoh, G. Morizono, K. Shikata et al., Colorectal cancer screening with odour material by canine scent detection, Gut (2011), Jan 31: Epub 10.1136/gut.2010.218305.
15. G. Peng, M. Hakim, Y. Y. Broza, S. Billan, R. Abdah-Bortnyak, A. Kuten, U. Tisch and H. Haick, Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors, Br J Cancer 10(2010), 542-551.
16. A. Lesniak, M. Walczak, T. Jezierski, M. Sacharczuk, M. Gawkowski and K. Jaszczak, Canine olfactory receptor gene polymorphism and its relation to odor detection performance by sniffer dogs, J Hered 99(2008), 518-527.
17. A. L. Petri, C. Høgdall, I. J. Christensen, A. H. Simonsen, D. T'jampens, M. L. Hellmann, S. K. Kjaer, E. T. Fung and E. Høgdall, Sample handling for mass spectrometric proteomic investigations of human urine, Proteomics Clin Appl 2(2008), 1184-1193.
18. P. Kaulfuss and D. S. Mills, Neophilia in domestic dogs (Canis familiaris) and its implication for studies of dog cognition, Anim Cogn 11(2008), 553-556.
19. M. Phillips, R. N. Cataneo, B. A. Ditkoff, P. Fisher, J. Greenberg, R. Gunawardena, C. S. Kwon, F. Rahbari-Oskoui and C. Wong, Volatile markers of breast cancer in the breath, Breast J 9(2003), 184-191.
20. T. Abaffy, R. Duncan, D. D. Riemer, O. Tietje, G. Elgart, C. Milikowski and R. A. DeFazio, Differential volatile signatures from skin, naevi and melanoma: a novel approach to detect a pathological process, PLoS One 5(2010), e13813.
21. T. Qin, H. Liu, Q. Song, G. Song, H. Z. Wang, Y. Y. Pan, F. X. Xiong, K. S. Gu, G. P. Sun and Z. D. Chen, The screening of volatile markers for hepatocellular carcinoma, Cancer Epidemiol Biomarkers Prev 19(2010), 2247-2253.
22. M. Ligor, T. Ligor, A. Bajtarevic, C. Ager, M. Pienz, M. Klieber, H. Denz, M. Fiegl, W. Hilbe, W. Weiss, P. Lukas, H. Jamnig, M. Hackl, B. Buszewski, W. Miekisch, J. Schubert and A. Amann, Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry, Clin Chem Lab Med 47(2009), 550-560.